Image coding quality assessment using fuzzy integrals with a three-component image model

Based on importance measures and fuzzy integrals, a new assessment method for image coding quality is presented in this paper. The proposed assessment is based on two subevaluations. In the first subevaluation, errors on edges, textures, and flat regions are computed individually. The errors are then assessed using an assessment function. A global evaluation with Sugeno fuzzy integral is then obtained based on the importance measure of edge, texture, and flat region. In the second subevaluation, an importance measure is first established depending on the types of regions where errors occur, a subtle evaluation is then obtained using Sugeno fuzzy integral on all pixels of the image. A final evaluation is obtained based on the two subevaluations. Experimental results show that this new image quality assessment closely approximates human subjective tests such as mean opinion score with a high correlation coefficient of 0.963, which is a significant improvement over peak signal-to-noise ratio, picture quality scale, and weighted mean square error, three other image coding quality assessment methods, which have the correlation coefficients of 0.821, 0.875, and 0.716, respectively.     

微机控制太阳能逆变电源

介绍了一种微机控制太阳能逆变电源,在这里微计算机按照给定的功率来控制逆变电源的输出电流,由于采用了锁相环技术,保证了逆变电源的输出与电网电压严格同步。控制器选用 Ｉｎｔｅｌ ８９Ｃ５１单片机,并在实验室中进行了实验,实验结果证明理论分析是正确的。     

安装黏滞阻尼器的摇摆结构抗震性能分析

摇摆结构放松了结构与基础间的约束或构件间的约束,这些连接处只受压而不受拉,在地震作用下发生摇摆而其本身又不产生弯曲变形。摇摆降低了地震作用和结构本身的延性设计需求,减小了地震破坏,节约了结构造价。论文提出一种新型摇摆结构,即在传统摇摆结构上安装黏滞阻尼器,研究该结构在地震作用下的反应特点与减震效果。通过与摇摆框架的地震响应分析对比,表明安装黏滞阻尼器的摇摆框架能大幅度提高结构的抗震性能,降低地震带来的危害。     

电流辅助对铆钉压铆过程及连接性能的影响

钛合金铆钉在塑性成型过程中存在变形抗力大、变形不均匀等问题。在铆接过程中引入电流辅助铆接技术可有效提升钛合金铆钉的铆接质量,其原理为通过在铆接过程中施加电流,改善金属铆钉塑性,提高铆钉的可加工性。以TA2M航空用铆钉为研究对象,研究了6种电流密度水平下铆钉的温升过程与成型效果,并开展拉伸试验与疲劳试验研究铆接件的力学性能。研究发现,通电会在较短时间内产生显著的焦耳热效应,这对难变形的钛合金铆钉来说是一种有效的热软化手段;通电带来的铆钉软化效应极大降低了加工难度,改善了镦头的成型效果;当通以电流密度为26 A/mm²的电流时,压铆力降低了24.69%,且镦头直径增大了6.80%,高度降低了14.04%,更加接近标准所要求的尺寸;电流辅助铆接技术对钛合金板连接件静态拉伸强度的影响不显著,但可有效提升连接件的疲劳寿命。     

Comprehensive Integrated Single-Cell Whole Transcriptome Analysis Revealed the p-EMT Tumor Cells—CAFs Communication in Oral Squamous Cell Carcinoma

Cancer-associated fibroblasts (CAFs) and partial epithelial–mesenchymal transition (p-EMT) tumor cells are closed together and contribute to the tumor progression of oral squamous cell carcinoma (OSCC). In the present study, we deeply analyzed and integrated OSCC single-cell RNA sequencing datasets to define OSCC CAFs and p-EMT subpopulations. We highlighted the cell–cell interaction network of CAFs and p-EMT tumor cells and suggested biomarkers for the diagnosis and prognosis of OSCC during the metastasis condition. The analysis discovered four subtypes of CAFs: one p-EMT tumor cell population, and cycling tumor cells as well as TNFSF12-TNFRSF25/TNFRSF12A interactions between CAFs and p-EMT tumor cells during tumor metastasis. This suggests the prediction of therapeutically targetable checkpoint receptor–ligand interactions between CAFs and p-EMT tumor cells in OSCC regarding the metastasis status.     

腔外旋转泵浦的Nd∶YAG固体激光器研究

固体激光器的热管理仍然是高功率激光系统发展的一个持续挑战。在激光系统中增益介质和泵浦光之间引入相对运动是一种高效的热管理方案。针对静止泵浦,旋转增益介质泵浦以及泵浦光旋转泵浦3种泵浦方式,借助有限元数值模拟方法分析了Nd∶YAG晶体的温度分布。泵浦光以800 r/min旋转时,在35 W泵浦功率下,使用标准的热沉冷却技术,晶体的最高温度达到约36 ℃,仅增加约16 ℃,这远低于静止泵浦时的142 ℃。实验设计并演示了一种腔外旋转泵浦的Nd∶YAG激光器,得到了12.2 W的1064 nm连续输出,斜率效率为37.2%,这大于静止时的35.1%,实验结果与理论结果相符合。研究表明,腔外旋转泵浦的固体激光器拥有高效的热管理。     

MicroRNAs as Potential Biomarkers in the Differential Diagnosis of Lipomatous Tumors and Their Mimics

Adipocytic tumors are the most common subtype of soft tissue tumors. In current clinical practice, distinguishing benign lipomas from well-differentiated liposarcomas (WDLPS), as well as dedifferentiated liposarcomas (DDLPS) from their morphologic mimics, remains a significant diagnostic challenge. This is especially so when examining small biopsy samples and without the aid of additional ancillary tests. Recognizing the important role that microRNAs (miRNAs) play in tumorigenesis and their potential utility in tumor classification, we analyzed routine clinical tissue samples of benign and malignant lipomatous tumors, as well as other sarcoma mimics, to identify distinguishing miRNA-based signatures that can aid in the differential diagnosis of these entities. We discovered a 6-miRNA signature that separated lipomas from WDLPS with high confidence (AUC of 0.963), as well as a separate 6-miRNA signature that distinguished DDLPS from their more aggressive histologic mimics (AUC of 0.740). Functional enrichment analysis unveiled possible mechanistic involvement of these predictive miRNAs in adipocytic cancer-related biological processes and pathways such as PI3K/AKT/mTOR and MAPK signaling, further supporting the relevance of these miRNAs as biomarkers for adipocytic tumors. Our results demonstrate that miRNA expression profiling may potentially be used as an adjunctive tool for the diagnosis of benign and malignant adipocytic tumors. Further validation studies are warranted.     

Mutated KIT Tyrosine Kinase as a Novel Molecular Target in Acute Myeloid Leukemia

KIT is a type-III receptor tyrosine kinase that contributes to cell signaling in various cells. Since KIT is activated by overexpression or mutation and plays an important role in the development of some cancers, such as gastrointestinal stromal tumors and mast cell disease, molecular therapies targeting KIT mutations are being developed. In acute myeloid leukemia (AML), genome profiling via next-generation sequencing has shown that several genes that are mutated in patients with AML impact patients’ prognosis. Moreover, it was suggested that precision-medicine-based treatment using genomic data will improve treatment outcomes for AML patients. This paper presents (1) previous studies regarding the role of KIT mutations in AML, (2) the data in AML with KIT mutations from the HM-SCREEN-Japan-01 study, a genome profiling study for patients newly diagnosed with AML who are unsuitable for the standard first-line treatment (unfit) or have relapsed/refractory AML, and (3) new therapies targeting KIT mutations, such as tyrosine kinase inhibitors and heat shock protein 90 inhibitors. In this era when genome profiling via next-generation sequencing is becoming more common, KIT mutations are attractive novel molecular targets in AML.     

用于直角电桥的数字信号发生器的设计

根据直角电桥的比例臂要求,设计并实现了一种基于FPGA和DDS技术的直角电压源,所设计直角电压源可用于直角阻抗的比较,并通过实验的方法给出了作为比例臂时的相对稳定性等指标.