一种转移脉冲宽度可调的CCD驱动电路

本文以TCD132D线阵CCD为例,介绍了一种用循环计数器和拨码开关共同作用改变CCD转移脉冲的CCD驱动电路。该电路结构简单,工作可靠,调整方便。     

Studies on purification and some properties of nisin from Lactococcus lactis subsp. lactis Al2

Protoporphyria is a genetic disorder in which patients may develop severe protoporphyrin-induced liver damage and require transplantation. Because unique problems occur in the perioperative period and because excess production of protoporphyrin by the bone marrow continues after liver transplantation, the efficacy of this procedure for protoporphyric liver disease is uncertain. We present follow-up of nine patients who underwent liver transplantation. Two patients died within 2 months of transplantation, one from complications of abdominal bleeding and the other from sepsis after bowel perforations. The remaining seven patients had follow-up at 14 months to 8 years after transplantation (mean, 3.8 years). Two of the seven had suffered skin burns from exposure to operating room lights, which healed without scarring. Three had axonal neuropathies in the postoperative period requiring prolonged mechanical ventilation, and motor defects persisted in two. Five patients had normal liver chemistries at follow-up (mean, 3.5 years), with liver biopsy results normal or showing mild portal triad abnormalities, but erythrocyte protoporphyrin levels remained significantly elevated (1,765 +/- 365 mcg/dL; normal, < 65). The other two patients, both of whom had rejection, cytomegalovirus infection, and biliary tract obstruction requiring endoscopic therapy, had a recurrence of protoporphyric liver disease as indicated by liver biopsy features. One died 5 years after transplantation from complications of the liver disease. The other was stable 3.3 years after transplantation and was being monitored for possible retransplantation. Thus, liver transplantation can be performed successfully in patients with protoporphyric liver disease, with intermediate survival rates comparable to the general transplant population. However, disease may recur in the graft, particularly if there are complications that cause cholestasis.     

Synthesis and characterization of cyclic pseudopeptide libraries containing thiomethylene and thiomethylene-sulfoxide amide bond surrogates

Resistance-modifying agents (RMAs) such as Verapamil have been proved to be effective in reversing multi-drug resistance (MDR) in many in vitro assays. In this study we have investigated the efficacy of Dex-Verapamil, the R-isomer of Verapamil, as a chemosensitizer in a murine leukemia cell line (P388) and in its resistant counterpart (P388/Dx) expressing a typical MDR phenotype. We have examined in vivo the effect of the co-administration of Dex-Verapamil and Doxorubicin in mice transplanted with P388 or P388/Dx cells. Mice treated with the combination of Doxorubicin plus RMA had a significant increase in survival rate as compared to controls; however, the effect was modest. On the contrary, in vitro Dex-Verapamil can enhance Doxorubicin cytotoxicity in P388/Dx cells with a much greater effect depending on the treatment scheme used, by increasing the intracellular content of drug. Taken together our data indicate that Dex-Verapamil can indeed increase the sensitivity to Doxorubicin in resistant cells, but the limited efficacy shown in vivo demonstrates that this phenomenon is strongly dependent on the treatment scheme used and on the maintenance of constantly elevated serum levels.     

连续式棒线材轧机孔型系统的选择

论述了连续式棒线材轧机孔型系统的种类和特点，介绍了粗轧机组和中轧机组孔型系统的选择原则和方法。     

对新闻专业主义“现实性”的思考

新闻专业主义在西方拥有很大的理论市场,但这一理念所具有的理想主义色彩也不容忽视。多年来,新闻专业主义在其发展过程中不断受到严峻的现实挑战。本文分析了新闻媒体新闻专业主义缺失的深层原因,认为政治权力和市场机制等制度性框缚是新闻专业主义难以发挥其预期效果的根源所在。同时指出,新闻专业主义并非新闻改革的唯一出路。     

Ranking with uncertain labels and its applications

The techniques for image analysis and classification generally consider the image sample labels fixed and without uncertainties. The rank regression problem studied in this paper is based on the training samples with uncertain labels, which often is the case for the manual estimated image labels. A core ranking model is designed first as the bilinear fusing of multiple candidate kernels. Then, the parameters for feature selection and kernel selection are learned simultaneously by maximum a posteriori for given samples and uncertain labels. The provable convergency Expectation Maximization (EM) method is used for inferring these parameters in an iterative manner. The effectiveness of the proposed algorithm is finally validated by the extensive experiments on age ranking task and human tracking task. The popular FG-NET and the large scale Yamaha aging database are used for the age estimation experiments, and our algorithm outperforms those state-of-the-art algorithms ever reported by other interrelated literatures significantly. The experiment result of human tracking task also validates its advantage over conventional linear regression algorithm. A short version of this paper appeared in ICME07.     

用熵方程证明全不可逆循环揭示的Clausius方程式

利用不可逆循环图代替传统的半不可逆循环推导出Clausius积分式，并用熵方程证明之，得出可逆过程膨胀功大于不可逆过程膨胀功。