Transforming One‐Dimensional Nanowalls to Long‐Range Ordered Two‐Dimensional Nanowaves: Exploiting Buckling Instability and Nanofibers Effect in Holographic Lithography

Two‐dimensional nanowaves with long‐range order are fabricated by exploiting swelling‐induced buckling of one‐dimensional (1D) nanowalls with nanofibers formed in‐between during holographic lithography of the negative‐tone photoresist SU‐8. The 1D film goes through a constrained swelling in the development stage, and becomes buckled above the critical threshold. The degree of lateral undulation can be controlled by tuning the pattern aspect ratio (height/width) and exposure dosage. At a high aspect ratio (e.g., 6) and a high exposure dosage, nanofibers (30–50 nm in diameter) are formed between the nanowalls as a result of overlapping of low crosslinking density regions. By comparing experimental results with finite‐element analysis, the buckling mechanism is investigated, which confirms that the nanofibers prevent the deformed nanowalls from recovery to their original state, thus, leading to long‐range ordered two‐dimensional (2D) wavy structures. The film with nanowaves show weaker reflecting color under an ambient light and lower transmittance compared to the straight nanowalls. Using double exposure through a photomask, patterns consisting of both nanowaves and nanowalls for optical display are created.     

Toward Advanced Mobile Cloud Computing for the Internet of Things: Current Issues and Future Direction

Cloud computing is the coming new era of information processing and has proved its benefits in high scalability and functional diversity. However, almost all cloud-computing architectures including SaaS, PaaS, and IaaS are vulnerable to serious security issues. Similarly, Mobile Cloud Computing (MCC) is vital to overcoming mobile limited storage and computing capabilities. MCC authentication and authorization issues must be provided on two levels: login password control and the environment from where the cloud is accessed. MCC has overcome the barrier of limited storage by providing remote storage but requires a strict security system that is responsible for retrievability, integrity, and seamless storage access. Elasticity and connectivity are also of major concern in MCC because delays and jitters cause degradation in the user experience. Cloud-computing architecture creates more challenges in maintaining security because of the liberty of users to choose any MCC architecture. Thus in this paper we discuss current cloud computing issues and future directions.     

3‐Level Envelope Delta‐Sigma Modulation RF Signal Generator for High‐Efficiency Transmitters

This paper presents a 0.13 μm CMOS 3‐level envelope delta‐sigma modulation (EDSM) RF signal generator, which synthesizes a 2.6 GHz‐centered fully symmetrical 3‐level EDSM signal for high‐efficiency power amplifier architectures. It consists of an I‐Q phase modulator, a Class B wideband buffer, an up‐conversion mixer, a D2S, and a Class AB wideband drive amplifier. To preserve fast phase transition in the 3‐state envelope level, the wideband buffer has an RLC load and the driver amplifier uses a second‐order BPF as its load to provide enough bandwidth. To achieve an accurate 3‐state envelope level in the up‐mixer output, the LO bias level is optimized. The I‐Q phase modulator adopts a modified quadrature passive mixer topology and mitigates the I‐Q crosstalk problem using a 50% duty cycle in LO clocks. The fabricated chip provides an average output power of –1.5 dBm and an error vector magnitude (EVM) of 3.89% for 3GPP LTE 64 QAM input signals with a channel bandwidth of 10/20 MHz, as well as consuming 60 mW for both channels from a 1.2 V/2.5 V supply voltage.     

Non-destructive testing of high strength concrete using spectral analysis of surface waves

Non-destructive testing is essential in the inspection of alteration, repair and new construction in construction industry. Researchers are exploring the performance of non-destructive testing method using spectral analysis of surface waves (SASW) in concrete structures. The method consists of the generation, measurement and processing of dispersive surface waves. In SASW test, the surface of the media under consideration is subject to an impact using, for example, a 12-mm steel ball, to generate surface wave energy at various frequencies. Two vertical accelerometer receivers detect the energy transmitted through the testing media. By recording signals in digitized form using a data acquisition system and processing them, surface wave velocity can be obtained using a dispersion curve. This study is to focus on understanding of the applicability and limitations of the SASW method in a high strength concrete. This study is also to characterize the material property of early age high strength concrete emphasizing compressive strength using non-destructive testing methods. Three high strength concrete slabs of 600, 850 and 1100 kg/cm² compressive strengths were prepared together with cylinders from same batches. Cylinder tests were performed at the ages of 7, 14, 21 and 28 days after pouring concrete. Using the impact-echo method, the compression wave velocities were obtained based on different high strength concrete ages and compressive strengths. The equation to obtain the compressive strengths of high strength concrete has been developed using the obtained compression wave velocities (f′_c=1.083V_p−3816.1143). Using the method, the equation has also been developed to obtain the compressive strengths of high strength concrete based on the surface wave velocities (f′_c=0.253V_p+16.271). This study can be utilized in examining structural elements of high strength concrete structures and be applied in the integrity analysis of high strength concrete structures with a finite thickness.     

一般化最小包含球的大样本快速学习方法

标准最小包含球(Minimum enclosing ball, MEB)模型的对偶问题可视为MEB问题并能够利用核心集向量机(Core vector machine, CVM)实现大样本的快速训练,但对于一般化MEB模型,对偶问题中的不等式约束发生了变化而不能视为MEB问题, 不能方便地使用CVM来解决大样本的快速训练.为此,提出了一般化MEB快速学习方法(Fast learning of generalized MEB, FL-GMEB),首先放松对偶问题中的不等式约束条件,使其等价于中心约束的MEB问题,从而利用CVM获得其核心集(Core set, CS);然后利用局部线性嵌入(Locally linear embedding, LLE)的逆思想将CS扩充为拓展核心集(Extended core set, ECS);最后将ECS及其对应的优化权作为一般化MEB模型的逼近解. UCI和USPS数据集上的实验结果表明, FL-GMEB在大样本快速训练方面具有较好的性能优势.     

Sintering and optical properties of transparent ZnS ceramics by pre-heating treatment temperature

The main objective of our work is to increase transmittance in the mid infrared region by removing impurities through the pre-heating treatment of zinc sulfide (ZnS) produced by hydrothermal synthesis. The pre-heating treatment proceeded at 450 to 600 °C for 2 h under vacuum atmosphere (10^?2 Torr). It was confirmed that the particle size increased as the pre-heating temperature increased. Additionally, all ZnS nano powders had a sphalerite (cubic) structure unaffected by pre-heating treatment. The ZnS nano powders were sintered by hot-press sintering method. As the pre-heating temperature increased, transmittance was improved due to the decreasing of porosity, increase of particle size, and the removal of impurities (carbon and sulfate). However, when the pre-heating treatment temperature was 600 °C, the transmittance slightly decreased due to the formation of a hexagonal phase. The ZnS ceramic with pre-heating treatment at 550 °C showed the highest transmittance (71.6%) and density (99.9%).     

Protective Effect of Resveratrol in an Experimental Model of Salicylate-Induced Tinnitus

To date, the effect of resveratrol on tinnitus has not been reported. The attenuative effects of resveratrol (RSV) on a salicylate-induced tinnitus model were evaluated by in vitro and in vivo experiments. The gene expression of the activity-regulated cytoskeleton-associated protein (ARC), tumor necrosis factor-alpha (TNFα), and NMDA receptor subunit 2B (NR2B) in SH-SY5Y cells was examined using qPCR. Phosphorylated cAMP response element-binding protein (p-CREB), apoptosis markers, and reactive oxygen species (ROS) were evaluated by in vitro experiments. The in vivo experiment evaluated the gap-prepulse inhibition of the acoustic startle reflex (GPIAS) and auditory brainstem response (ABR) level. The NR2B expression in the auditory cortex (AC) was determined by immunohistochemistry. RSV significantly reduced the salicylate-induced expression of NR2B, ARC, and TNFα in neuronal cells; the GPIAS and ABR thresholds altered by salicylate in rats were recovered close to their normal range. RSV also reduced the salicylate-induced NR2B overexpression of the AC. These results confirmed that resveratrol exerted an attenuative effect on salicylate-induced tinnitus and may have a therapeutic potential.     

4-O-Methylascochlorin-Mediated BNIP-3 Expression Controls the Balance of Apoptosis and Autophagy in Cervical Carcinoma Cells

4-O-methylascochlorin (MAC) is a 4-fourth carbon-substituted derivative of ascochlorin, a compound extracted from a phytopathogenic fungus Ascochyta viciae. MAC induces apoptosis and autophagy in various cancer cells, but the effects of MAC on apoptosis and autophagy in cervical cancer cells, as well as how the interaction between apoptosis and autophagy mediates the cellular anticancer effects are not known. Here, we investigated that MAC induced apoptotic cell death of cervical cancer cells without regulating the cell cycle and promoted autophagy by inhibiting the phosphorylation of serine-threonine kinase B (Akt), mammalian target of rapamycin (mTOR), and 70-kDa ribosomal protein S6 kinase (p70S6K). Additional investigations suggested that Bcl-2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP-3), but not Hypoxia-inducible factor 1 alpha (HIF-1α), is a key regulator of MAC-induced apoptosis and autophagy. BNIP-3 siRNA suppressed MAC-induced increases in cleaved- poly (ADP-ribose) polymerase (PARP) and LC3II expression. The pan-caspase inhibitor Z-VAD-FMK suppressed MAC-induced cell death and enhanced MAC-induced autophagy. The autophagy inhibitor chloroquine (CQ) enhanced MAC-mediated cell death by increasing BNIP-3 expression. These results indicate that MAC induces apoptosis to promote cell death and stimulates autophagy to promote cell survival by increasing BNIP-3 expression. This study also showed that co-treatment of cells with MAC and CQ further enhanced the death of cervical cancer cells.