基于知识工程的智能优化软件系统IOPS

根据知识工程理论研究了一种智能型的优化设计软件系统IOPS。该系统集成了连续、离散、随机变量的14种优化算法程序,并通过模型诊断、算法选择、多目标决策、参数设计等专家系统的并行操作,实现了优化设计过程自动化。     

Mechanisms of Pannexin 1 (PANX1) Channel Mechanosensitivity and Its Pathological Roles

Pannexins (PANX) were cloned based on their sequence homology to innexins (Inx), invertebrate gap junction proteins. Although there is no sequence homology between PANX and connexins (Cx), these proteins exhibit similar configurations. The PANX family has three members, PANX1, PANX2 and PANX3. Among them, PANX1 has been the most extensively studied. The PANX1 channels are activated by many factors, including high extracellular K⁺ ([K⁺]_e), high intracellular Ca²⁺ ([Ca²⁺]_i), Src family kinase (SFK)-mediated phosphorylation, caspase cleavage and mechanical stimuli. However, the mechanisms mediating this mechanosensitivity of PANX1 remain unknown. Both force-from-lipids and force-from-filaments models are proposed to explain the gating mechanisms of PANX1 channel mechanosensitivity. Finally, both the physiological and pathological roles of mechanosensitive PANX1 are discussed.     

基于CFD的学生宿舍通风方式研究

首先采用德图testo435-635-735风速仪测量学生宿舍内风速,然后利用计算流体力学技术,建立了学生宿舍物理模型和数学模型,对宿舍的通风状况进行了模拟计算.湍流模型采用室内零方程模型,速度压力解耦采用SIMPLE算法.对模拟计算结果和试验获得的数据进行了比较验证.在验证模拟计算的准确性的基础上,计算比较宿舍内卫生间靠近窗户侧和卫生间在走廊侧两种布局下,日常生活中的空气新鲜程度;计算比较了宿舍内卫生间靠近窗户侧和卫生间在走廊侧两种布局下,比如非典等传染病突发状况下污染物扩散的快速程度,对污染物从六个床位散发出来的情况进行逐个模拟计算,逐个比较两种布局下的硫化氢质量比例分布.计算结果表明,当宿舍门关闭卫生间排气扇打开时,卫生间靠近走廊侧的空气明显比卫生间靠近窗户侧新鲜;并且突发状况下,卫生间靠近走廊侧的污染物扩散也明显比卫生间靠近窗户侧的快.     

基于磁场传感器的层状磁电复合材料动态特性的有限元模型研究

依据Hamilton变分原理,运用有限元方法建立了用于磁场传感器的核心元件—磁电复合材料动态特性的有限元模型。应用所建立的模型求解了LT型Terfenol-D/PZT/Terfenol-D三层磁电复合材料的输出特性,并与实验结果进行对比分析。结果发现当静态偏置磁场为22.1 kA/m,正弦交流驱动磁场为7.4 kA/m、频率100 Hz时,计算结果和实验结果误差为0.9%。表明该模型适用于磁电复合材料输出特性为线性变化的区域。