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This paper presents a theoretical investigation into heat generation in the continued quasi-static plane strain compression of a thin metal strip between two rigid, parallel perfectly rough dies. The strip material is rigid perfectly plastic. The length of the dies is supposed to be much larger than the current strip thickness. The plastic work rate approaches infinity in the vicinity of perfectly rough friction surfaces. Since the plastic work rate is involved in the heat conduction equation, this significantly adds to the difficulties of solutions of this equation. In particular, commercial finite element packages are not capable of solving such boundary value problems. The present approximate solution is given in Lagrangian coordinates. In this case, the original initial/boundary value problem reduces to the standard second initial/boundary value problem for the nonhomogeneous heat conduction equation. Therefore, the Green’s function is available in the literature. An example is presented to illustrate the general solution. 相似文献
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The resistance of extractants to light is important during industrial extraction processes. A photodegradation of the organothiophosphorous extractant Cyanex 301 in toluene and hexane as organic diluent and the identification of possible degradation products using FT-IR and GC-MS techniques were performed. The influence of copper(II) and cobalt(II) ions on the stability of the extractant under UV-vis light exposure was also studied. The changes in the percentage composition of individual components of the extractant depended on the types of organic diluents and copper or cobalt ions. During this process, copper complex irradiation precipitation of black powder and photooxidation of toluene were observed. Based on these results we proposed a hypothetical mechanism of photodegradation of extractant Cyanex 301. 相似文献
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Paulina Natalia Osuchowska Przemysaw Wachulak Wiktoria Kasprzycka Agata Nowak-Stpniowska Maciej Wakua Andrzej Bartnik Henryk Fiedorowicz Elbieta Anna Trafny 《International journal of molecular sciences》2021,22(14)
Understanding cancer cell adhesion could help to diminish tumor progression and metastasis. Adhesion mechanisms are currently the main therapeutic target of TNBC-resistant cells. This work shows the distribution and size of adhesive complexes determined with a common fluorescence microscopy technique and soft X-ray contact microscopy (SXCM). The results presented here demonstrate the potential of applying SXCM for imaging cell protrusions with high resolution when the cells are still alive in a physiological buffer. The possibility to observe the internal components of cells at a pristine and hydrated state with nanometer resolution distinguishes SXCM from the other more commonly used techniques for cell imaging. Thus, SXCM can be a promising technique for investigating the adhesion and organization of the actin cytoskeleton in cancer cells. 相似文献
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Anna Nowak Paula Ossowicz-Rupniewska Rafa Rakoczy Maciej Konopacki Magdalena Peruyska Marek Dro
dzik Edyta Makuch Wiktoria Duchnik ukasz Kucharski Karolina Wenelska Adam Klimowicz 《International journal of molecular sciences》2021,22(12)
Bacterial cellulose membranes (BCs) are becoming useful as a drug delivery system to the skin. However, there are very few reports on their application of plant substances to the skin. Komagataeibacter xylinus was used for the production of bacterial cellulose (BC). The BC containing 5% and 10% ethanolic extract of Epilobium angustifolium (FEE) (BC-5%FEE and BC-10%FEE, respectively) were prepared. Their mechanical, structural, and antioxidant properties, as well as phenolic acid content, were evaluated. The bioavailability of BC-FESs using mouse L929 fibroblasts as model cells was tested. Moreover, In Vitro penetration through the pigskin of the selected phenolic acids contained in FEE and their accumulation in the skin after topical application of BC-FEEs was examined. The BC-FEEs were characterized by antioxidant activity. The BC-5% FEE showed relatively low toxicity to healthy mouse fibroblasts. Gallic acid (GA), chlorogenic acid (ChA), 3,4-dihydroxybenzoic acid (3,4-DHB), 4-hydroxybenzoic acid (4-HB), 3-hydroxybenzoic acid (3-HB), and caffeic acid (CA) found in FEE were also identified in the membranes. After topical application of the membranes to the pigskin penetration of some phenolic acid and other antioxidants through the skin as well as their accumulation in the skin was observed. The bacterial cellulose membrane loaded by plant extract may be an interesting solution for topical antioxidant delivery to the skin. 相似文献
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Lipińska Wiktoria Grochowska Katarzyna Karczewski Jakub Coy Emerson Siuzdak Katarzyna 《Journal of Materials Science》2022,57(28):13345-13361
Journal of Materials Science - In this work, we present the catalytic and photocatalytic activity of AuCu nanostructures obtained on TiO2 nanotubes toward methanol, ethylene glycol and glycerine... 相似文献
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Katarzyna Niesyto Wiktoria yniak Magdalena Skonieczna Dorota Neugebauer 《International journal of molecular sciences》2021,22(14)
In vitro cytotoxicity of polymer-carriers, which in the side chains contain the cholinum ionic liquid units with chloride (Cl) or pharmaceutical anions dedicated for antituberculosis therapy, i.e., p-aminosalicylate (PAS) and clavulanate (CLV), was investigated. The carriers and drug conjugates were examined, in the concentration range of 3.125–100 μg/mL, against human bronchial epithelial cells (BEAS-2B) and adenocarcinomic human alveolar basal epithelial cells (A549) as an experimental model cancer cell line possibly coexisting in tuberculosis. The cytotoxicity was evaluated by MTT test and confluency index, as well as by the cytometric analyses, including Annexin-V FITC apoptosis assay. The polymer systems showed supporting activity towards the normal cells and no tumor progress, especially at the highest concentration (100 μg/mL). The analysis of cell death did not show meaningful changes in the case of the BEAS-2B, whereas in the A549 cell line, the cytostatic activity was observed, especially for the drug-free carriers, causing death in up to 80% of cells. This can be regulated by the polymer structure, including the content of cationic units, side-chain length and density, as well as the type and content of pharmaceutical anions. The results of MTT tests, confluency, as well as cytometric analyses, distinguished the polymer systems with Cl/PAS/CLV containing 26% of grafting degree and 43% of ionic units or 46% of grafting degree and 18% of ionic units as the optimal systems. 相似文献
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Aleksandra Szczepkowska Maciej Wjcik Dorota Tomaszewska-Zaremba Hanna Antushevich Agata Krawczyska Wiktoria Wiechetek Janina Skipor Andrzej Przemysaw Herman 《International journal of molecular sciences》2021,22(24)
This study was designed to determine the effect of acute caffeine (CAF) administration, which exerts a broad spectrum of anti-inflammatory activity, on the synthesis of pro-inflammatory cytokines and their receptors in the hypothalamus and choroid plexus (ChP) during acute inflammation caused by the injection of bacterial endotoxin—lipopolysaccharide (LPS). The experiment was performed on 24 female sheep randomly divided into four groups: control; LPS treated (iv.; 400 ng/kg of body mass (bm.)); CAF treated (iv.; 30 mg/kg of bm.); and LPS and CAF treated. The animals were euthanized 3 h after the treatment. It was found that acute administration of CAF suppressed the synthesis of interleukin (IL-1β) and tumor necrosis factor (TNF)α, but did not influence IL-6, in the hypothalamus during LPS-induced inflammation. The injection of CAF reduced the LPS-induced expression of TNF mRNA in the ChP. CAF lowered the gene expression of IL-6 cytokine family signal transducer (IL6ST) and TNF receptor superfamily member 1A (TNFRSF1) in the hypothalamus and IL-1 type II receptor (IL1R2) in the ChP. Our study on the sheep model suggests that CAF may attenuate the inflammatory response at the hypothalamic level and partly influence the inflammatory signal generated by the ChP cells. This suggests the potential of CAF to suppress neuroinflammatory processes induced by peripheral immune/inflammatory challenges. 相似文献
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