This paper presents an interlaboratory test campaign organized by the RILEM 182-PEB Technical Committee. In the campaign,
11 different test methods, comprising uniaxial tension/compression, 2-, 3- and 4-point bending and indirecttension tests,
were utilized in order to investigate fatigue characteristics of a dense graded asphalt concrete mixture. The testing conditions
specified were sinusoidal excitation at 10Hz and 10°C using controlled strain and stress modes. In total, more than 150 fatigue
tests were carried out during the investigation. The fatigue test results were analyzed using both classical as well as continuum
damage mechanics approaches. The fatigue test results obtained using the classical fatigue approach are considerably influenced
by test type and mode of loading (controlled stress or strain) used. Consequently, this approach has limited use in realistic
fatigue characterization of bituminous materials and pavement structures. In contrast to the classical approach, models founded
on continuum damage theory may serve to isolate intrinsic fatigue characteristics from the influence of so-called biased effects,
which are largely caused by the accelerated laboratory testing. The continuum damage models investigated may constitute steps,
towards a rational mechanistic fatigue characterization model, which are important for effective future pavement design. 相似文献
To assess the tumour dimensions in uveal melanoma patients using 7-T ocular MRI and compare these values with conventional ultrasound imaging to provide improved information for treatment options.
Materials and methods
Ten uveal melanoma patients were examined on a 7-T MRI system using a custom-built eye coil and dedicated 3D scan sequences to minimise eye-motion-induced image artefacts. The maximum tumour prominence was estimated from the three-dimensional images and compared with the standard clinical evaluation from 2D ultrasound images.
Results
The MRI protocols resulted in high-resolution motion-free images of the eye in which the tumour and surrounding tissues could clearly be discriminated. For eight of the ten patients the MR images showed a slightly different value of tumour prominence (average 1.0 mm difference) compared to the ultrasound measurements, which can be attributed to the oblique cuts through the tumour made by the ultrasound. For two of these patients the more accurate results from the MR images changed the treatment plan, with the smaller tumour dimensions making them eligible for eye-preserving therapy.
Conclusion
High-field ocular MRI can yield a more accurate measurement of the tumour dimensions than conventional ultrasound, which can result in significant changes in the prescribed treatment.
The introduction of functional moieties in the donor polymer (side chains) offers a potential pathway toward selective modification of the nanomorphology of conjugated polymer:fullerene active layer blends applied in bulk heterojunction organic photovoltaics, pursuing morphology control and solar cell stability. For this purpose, two types of poly(3-alkylthiophene) random copolymers, incorporating different amounts (10/30/50%) of ester-functionalized side chains, were efficiently synthesized using the Rieke method. The solar cell performance of the functionalized copolymers was evaluated and compared to the pristine P3HT:PCBM system. It was observed that the physicochemical and opto-electronic characteristics of the polythiophene donor material can be modified to a certain extent via copolymerization without (too much) jeopardizing the OPV efficiency, as far as the functionalized side chains are introduced in a moderate ratio (<30%) and that preference is given to side chains with a small molar volume. A range of complementary techniques – UV–Vis spectroscopy, (modulated temperature) differential scanning calorimetry, transmission electron microscopy and X-ray diffraction analysis – indicated that variations in polymer crystallinity, while maintaining a high level of regioregularity, are probably the main factor responsible for the observed differences. 相似文献
Bone formation (osteogenesis) is a complex process in which cellular differentiation and the generation of a mineralized organic matrix are synchronized to produce a hybrid hierarchical architecture. To study the mechanisms of osteogenesis in health and disease, there is a great need for functional model systems that capture in parallel, both cellular and matrix formation processes. Stem cell-based organoids are promising as functional, self-organizing 3D in vitro models for studying the physiology and pathology of various tissues. However, for human bone, no such functional model system is yet available. This study reports the in vitro differentiation of human bone marrow stromal cells into a functional 3D self-organizing co-culture of osteoblasts and osteocytes, creating an organoid for early stage bone (woven bone) formation. It demonstrates the formation of an organoid where osteocytes are embedded within the collagen matrix that is produced by the osteoblasts and mineralized under biological control. Alike in in vivo osteocytes, the embedded osteocytes show network formation and communication via expression of sclerostin. The current system forms the most complete 3D living in vitro model system to investigate osteogenesis, both in physiological and pathological situations, as well as under the influence of external triggers (mechanical stimulation, drug administration). 相似文献
Operational decision-making processes for networked infrastructure management often occur as a multi-actor planning problem, implying these are based on negotiations between different stakeholders in addition to available system quality information. As such, does more accurate data about actual structural condition lead to other or better decision-making? A serious game is introduced, Maintenance in Motion, aiming at investigating the influence of information quality on rehabilitation decisions, for single- and multi-actor decision-making. Players manage drinking water, gas, sewer and street infrastructures. They are to balance their individual goal, cost-effectiveness, with their team utility, increasing overall infrastructure quality to minimise failure while minimising overall public costs. The game design, calibration and solution space are presented. 相似文献
The process of elicitation and synthesis of the collective understanding of a cultural domain held by a group of stakeholders is challenging. This problem typifies the pre-project activity from which a coherent understanding of the benefits sought from infrastructure investment must emerge to inform the business case rationale. The anthropological freelisting method is evaluated as a solution by determining its ability to be operationalized in a practical form for project application. Using data from the stakeholders of a large NHS Scotland building project, the use of multidimensional scaling for data analysis is compared with participatory pilesorting to determine which freelisting protocol balances insight with practicality. Neither approach is found to offer an ideal method of characterizing sought benefits. The social construction of pilesorting promotes reliability while the analytical rigour of multidimensional scaling remains attractive to auditors. Their distinct insights suggest that both approaches should be combined in future and used alongside further post-elicitation devices from anthropology such as cultural consensus modelling or structured conceptualization. 相似文献
Barium titanate (BaTiO3) thin films are prepared by conventional 2-methoxy ethanol-based chemical solution deposition. We report highly c-axis-oriented BaTiO3 thin films grown on silicon substrates, coated with a lanthanum oxynitrate buffer layer of 8.9 nm. The influence of the intermediate buffer layer on the crystallization of BaTiO3 film is investigated. The annealing temperature and buffer layer sintering conditions are optimized to obtain good crystal growth. X-ray diffraction measurements show the growth of highly oriented BaTiO3 thin films having a single perovskite phase with tetragonal geometry. The scanning electron microscopy and atomic force microscopy studies indicate the presence of smooth, crack-free, uniform layers, with densely packed crystal grains on the silicon surface. A BaTiO3 film of 150-nm thickness, deposited on a buffer layer of 7.2 nm, shows a dielectric constant of 270, remnant polarization (2Pr) of 5 μC/cm2, and coercive field (Ec) of 60 kV/cm. 相似文献
In situ X-ray absorption spectroscopy (XAS) has been performed to investigate the active site on Au-based catalysts in the water-gas
shift (WGS) reaction. The surface area and hence the WGS activity is higher for AuTiO2 catalysts supported on carbon nanofibres (CNF) than TiO2. The WGS reaction rate depends on the Au coordination number with an apparent maximum close to eight which corresponds to
a particle size of approximately 2.5–3.0 nm. A likely cause for the changes in the electronic structure of Au is the adsorption
of CO on the surface, which also creates a small positive charge in the Au atoms. The catalytic activity significantly improves
when titania is present compared to Au deposited directly on CNF. 相似文献