Bioengineered magnetoferritin nanozymes for pathological identification of high-risk and ruptured atherosclerotic plaques in humans

Atherosclerotic plaque rupture results in thrombus formation and vessel occlusion, and is the leading cause of death worldwide. There is a pressing need to identify plaque vulnerability for the treatment of carotid and coronary artery diseases. Nanomaterials with enzyme-like properties have attracted significant interest by providing biological, diagnostic and prognostic information about the diseases. Here we showed that bioengineered magnetoferritin nanoparticles (M-HFn NPs) functionally mimic peroxidase enzyme and can intrinsically recognize plaque-infiltrated active macrophages, which drive atherosclerotic plaque progression and rupture and are significantly associated with the plaque vulnerability. The M-HFn nanozymes catalyze the oxidation of colorimetric substrates to give a color reaction that visualizes the recognized active macrophages for one-step pathological identification of plaque vulnerability. We examined 50 carotid endarterectomy specimens from patients with symptomatic carotid disease and demonstrated that the M-HFn nanozymes could distinguish active macrophage infiltration in ruptured and high-risk plaque tissues, and M-HFn staining displayed a significant correlation with plaque vulnerability (r = 0.89, P < 0.0001).

     

Novel high-energy ionic molecules deriving from new monovalent and divalent 4-oxyl-3,5-dinitropyrazolate moieties

ABSTRACT

In recent years, the exploration of a practical strategy for novel energetic molecules with high energy and low sensitivity is very desirable but highly challenging. Novel ionic energetic molecules have attracted much attention in this area due to their prominent advantages including low sensitivities, high thermal stability, and excellent energy performances. Herein, five different ionic energetic molecules based on new monovalent and divalent 4-oxyl-3,5-dinitropyrazolate moieties with enhanced oxygen balance have been synthesized, characterized and evaluated as potential high-energy materials. Thermal stability, sensitivities and energy output test were measured and studied in detail. The heats of formation and energetic parameters were calculated by using Gaussian 09 suite of programs and EXPLO 5 code. The results suggest that all as-prepared new molecules exhibit good thermal stability with high decomposition temperature (3, 231°C; 5, 160°C; 6, 185°C; 7, 180°C; 8, 213°C), and relative low sensitivity (IS > 20 J, FS = 324 N). Inheriting the significant oxygen content of monovalent and divalent 4-oxyl-3,5-dinitropyrazolate moieties, they also possess good energy properties (v _D = 8238 ~ 9208 m s^?1, P = 26.8 ~ 36.7 GPa, V _o = 481.8 ~ 959.4 L kg^?1), which make them competitive high-energy materials.     

对硅质挂钩砖在烤窑过程中炸裂问题的探讨

由于种种原因,硅质挂钩砖在烤窑过程中经常出现炸裂,给窑炉的安全使用留下重大隐患.结合在烤窑过程中的体会对此进行一些简要的分析探讨,并提出预防措施和出现问题后的补救办法.     

凹凸棒石黏土脱色剂对航空煤油脱色研究

介绍了凹凸棒石黏土作为脱色剂,对航空煤油脱色.通过正交实验研究了活化酸度、焙烧温度、AlCl3加入量、脱色剂的用量和脱色时间对航空煤油脱色的影响.结果表明,经6%的硫酸酸化和450℃焙烧处理后的凹凸棒石黏土,加入1%AlCl;,制备的脱色剂脱色效果最佳,可使航空煤油的脱色率达到98.3%.     

煤炭城市环境承载力评估的探讨

本文综述了国内外环境承载力评估的进展及发展趋势，分析了城市环境承载力的特点及煤炭城市环境承载力评估的必要性，并对研究工作进行了展望。同时指出基于GIS的煤炭城市环境承载力评估是一个重要的研究方向，有待于多学科专家进一步探索、丰富和发展。     

煤体结构类型判断的超声波探测系统研究

实践证明煤体结构和煤与瓦斯突出灾害之间存在着密切的联系。但是在可以实现快速、准确判断煤体结构类型的设备开发方面仍然存在不足。介绍了一种基于超声波方法的煤体结构类型检测系统。该系统根据超声波在固体介质中的传播性质，通过对超声波速的测量，实现对煤体结构类型的判断。     

工程塑料系列泵的设计及在矿山等行业的应用

介绍了可输送含颗粒介质的HTB型、大流量工程塑料泵的材质、水力模型、压制、轴封结构研制设计，及在矿山等行业中的应用。     

NJM—10大力矩马达定子内曲线专用加工设备的设计

介绍了ＮＪＭ－１０大力矩马达定子内曲线专用加工中设备中核心元件－凸轮的设计，加工及检验方法。