环F2+uF2的Galois扩张上的迹码

环F2+uF2是介于环Z4与域F4之间的一种四元素环,因此分享了环Z4与域F4 的一些好的性质,此环上的编码理论研究成为一个新的热点。该文给出了环F2+uF2 的Galois扩张的相关理论,指出此Galois扩环的自同构群不同于Z4环上的Galois扩环的自同构群;定义了Galois扩环上的迹码的概念及子环子码的概念,证明了此Galois扩环上的一个码的对偶码的迹码是该环的子环子码的对偶码。     

FPGA仿真验证工具及前沿技术综述

随着FPGA设计应用的场合越来越多、越广,尤其在航天、军工等国防方面对FPGA设计的功能实现、安全性可靠性提出了更高的要求,因此,对于FPGA设计的验证就显得更加重要。主要针对目前市场上先进的FPGA仿真工具进行了深入的介绍和比较,同时还分析了FPGA仿真验证技术的发展方向,为FPGA验证工程师仿真验证工具的选择提供了参考。     

催化精馏法合成乙二醇单甲醚的模拟研究

提出以环氧乙烷和甲醇为原料,应用催化精馏技术合成乙二醇单甲醚的工艺方法.采用基于非平衡级模型的模拟方法,考察关键操作参数对目的产物选择性和收率的影响,并得到优化的操作条件为400 kPa,377 K,甲醇和环氧乙烷流量均为0.078 mol/s,再沸比9,反应段高度1.8 m,提馏段高度3.2 m.建立了中试规模的催化精馏塔对模拟结果进行了验证.结果表明,采用催化精馏法合成乙二醇单甲醚,在优化条件下乙二醇单甲醚收率达到93%以上.实验结果与模拟结果吻合良好,表明模拟方法可靠.     

用NetSolve构建数值计算网格

介绍了网格中间件NetSolve的体系结构及其工作过程,讨论了使用NetSolve软件搭建数值计算网格的基本过程,以简单实例说明如何调用计算网格的计算服务。     

氮气保护在PP熔体流动速率测试中的作用

通过比较在有、无氮气保护的情况下聚丙烯(PP)熔体质量流动速率和熔体体积流动速率测试值的不同,探讨了PP熔体流动速率测试过程中氮气保护的作用。无氮气情况下PP在高温发生热氧化降解,分子链断裂,熔体变稀,致使测得的熔体流动速率值偏大;使用氮气吹扫可有效保护试样,更准确地测定熔体流动速率。     

Neutronics analysis for MSR cell with different fuel salt channel geometries

The neutronic properties of molten salt reactors (MSRs) differ from those of traditional solid fuel reactors owing to their nuclear fuel particularity. Based on...     

The Insulin Receptor: An Important Target for the Development of Novel Medicines and Pesticides

The insulin receptor (IR) is a transmembrane protein that is activated by ligands in insulin signaling pathways. The IR has been considered as a novel therapeutic target for clinical intervention, considering the overexpression of its protein and A-isoform in multiple cancers, Alzheimer’s disease, and Type 2 diabetes mellitus in humans. Meanwhile, it may also serve as a potential target in pest management due to its multiple physiological influences in insects. In this review, we provide an overview of the structural and molecular biology of the IR, functions of IRs in humans and insects, physiological and nonpeptide small molecule modulators of the IR, and the regulating mechanisms of the IR. Xenobiotic compounds and the corresponding insecticidal chemicals functioning on the IR are also discussed. This review is expected to provide useful information for a better understanding of human IR-related diseases, as well as to facilitate the development of novel small-molecule activators and inhibitors of the IR for use as medicines or pesticides.     

Factors Associated with White Fat Browning: New Regulators of Lipid Metabolism

Mammalian adipose tissue can be divided into white and brown adipose tissue based on its colour, location, and cellular structure. Certain conditions, such as sympathetic nerve excitement, can induce the white adipose adipocytes into a new type of adipocytes, known as beige adipocytes. The process, leading to the conversion of white adipocytes into beige adipocytes, is called white fat browning. The dynamic balance between white and beige adipocytes is closely related to the body’s metabolic homeostasis. Studying the signal transduction pathways of the white fat browning might provide novel ideas for the treatment of obesity and alleviation of obesity-related glucose and lipid metabolism disorders. This article aimed to provide an overview of recent advances in understanding white fat browning and the role of BAT in lipid metabolism.     

Tumor-Localized Administration of α-GalCer to Recruit Invariant Natural Killer T Cells and Enhance Their Antitumor Activity against Solid Tumors

Invariant natural killer T (iNKT) cells have the capacity to mount potent anti-tumor reactivity and have therefore become a focus in the development of cell-based immunotherapy. iNKT cells attack tumor cells using multiple mechanisms with a high efficacy; however, their clinical application has been limited because of their low numbers in cancer patients and difficulties in infiltrating solid tumors. In this study, we aimed to overcome these critical limitations by using α-GalCer, a synthetic glycolipid ligand specifically activating iNKT cells, to recruit iNKT to solid tumors. By adoptively transferring human iNKT cells into tumor-bearing humanized NSG mice and administering a single dose of tumor-localized α-GalCer, we demonstrated the rapid recruitment of human iNKT cells into solid tumors in as little as one day and a significantly enhanced tumor killing ability. Using firefly luciferase-labeled iNKT cells, we monitored the tissue biodistribution and pharmacokinetics/pharmacodynamics (PK/PD) of human iNKT cells in tumor-bearing NSG mice. Collectively, these preclinical studies demonstrate the promise of an αGC-driven iNKT cell-based immunotherapy to target solid tumors with higher efficacy and precision.