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981.
Discovery of Heterocyclic Nonacetamide Synaptic Vesicle Protein 2A (SV2A) Ligands with Single‐Digit Nanomolar Potency: Opening Avenues towards the First SV2A Positron Emission Tomography (PET) Ligands
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Joël Mercier Laurence Archen Véronique Bollu Stéphane Carré Yves Evrard Dr. Eric Jnoff Dr. Benoît Kenda Bénédicte Lallemand Dr. Philippe Michel Dr. Florian Montel Dr. Florence Moureau Nathalie Price Dr. Yannick Quesnel Dr. Xavier Sauvage Dr. Anne Valade Dr. Laurent Provins 《ChemMedChem》2014,9(4):693-698
The role of the synaptic vesicle protein 2A (SV2A) protein, target of the antiepileptic drug levetiracetam, is still mostly unknown. Considering its potential to provide in vivo functional insights into the role of SV2A in epileptic patients, the development of an SV2A positron emission tomography (PET) tracer has been undertaken. Using a 3D pharmacophore model based on close analogues of levetiracetam, we report the rationale design of three heterocyclic non‐acetamide lead compounds, UCB‐A, UCB‐H and UCB‐J, the first single‐digit nanomolar SV2A ligands with suitable properties for development as PET tracers. 相似文献
982.
Zoltán Hegedűs Jenő Gubicza Péter Szommer Nguyen Q. Chinh Yi Huang Terence G. Langdon 《Journal of Materials Science》2013,48(21):7384-7391
The softening in ultrafine-grained silver processed by high-pressure torsion (HPT) was studied during annealing using differential scanning calorimetry (DSC). Two separate exothermic peaks were observed in the DSC thermogram of the HPT-processed sample. It is shown that the first and the second peaks are related to the recrystallization of the middle volume and the surface regions of the HPT-processed disk, respectively. Therefore, a very inhomogeneous sandwich-like microstructure develops during annealing with a soft interior and hard surface layers. The lower thermal stability of the middle region appears to be related to the stronger twinning activity since the twinned volumes can act as nuclei for recrystallized grains. The higher twin-fault probability in the interior is attributed to the larger strain due to the outflow of material between the anvils of the HPT facility during quasi-constrained processing. 相似文献
983.
B. P. Falcão J. P. Leitão J. C. González M. R. Correia K. G. Zayas-Bazán F. M. Matinaga M. B. Moreira C. F. Leite A. G. de Oliveira 《Journal of Materials Science》2013,48(4):1794-1798
Mg-doped GaAs nanowires have been grown by molecular beam epitaxy on a partially Au-coated Si(111) substrate by the vapor–liquid–solid mechanism. Outside the coated areas, a thin film of GaAs was grown epitaxially at the same time. The optical properties in both parts of the sample were investigated by photoluminescence spectroscopy, as a function of temperature. A structured emission in the range ~1.25–1.55 eV was observed at 10 K and the resemblances in both cases were identified. The radiative transitions are discussed with relevance to known defect centers in the GaAs thin films and to their possible relation with the zinc-blende and wurtzite phases in the nanowires. The presence of both crystalline phases in the nanowires was confirmed by μ-Raman spectroscopy. 相似文献
984.
Amanda Alonso Xavier Muñoz‐Berbel Núria Vigués Rosalía Rodríguez‐Rodríguez Jorge Macanás Maria Muñoz Jordi Mas Dmitri N. Muraviev 《Advanced functional materials》2013,23(19):2450-2458
Cation exchange polymeric matrices are widely used in water treatment protocols to reduce the mineral content of hard waters, even for human consumption. However, they are not antibacterial and flowing bacteria can be trapped in their structures and proliferate, thus acting as microbial contamination sources. Here, Ag@Co‐nanoparticles (Ag@Co‐NPs) with a low‐cost superparamagnetic Co0‐core and an antibacterial Ag‐shell are synthesized on granulated cation exchange polymeric matrices under soft reaction conditions. The presence of these NPs provides the final nanocomposite (NC) with additional functionalities (superparamagnetism and antibacterial activity) making it ideal for water purification applications. Ag@Co‐NPs are synthesized in situ on four cation exchange polymeric matrices containing either strong (sulfonic) or weak (carboxylic) acid functional groups homogeneously distributed (C‐type) or concentrated on an external shell (SST‐type) by the intermatrix synthesis (IMS) method. The NCs are characterized (metal content, NP size and distribution, metal oxidative state, and metal release) and evaluated for water purification applications. 相似文献
985.
An adaptive color similarity function suitable for image segmentation and its numerical evaluation
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Rodolfo Alvarado‐Cervantes Edgardo M. Felipe‐Riverón Vladislav Khartchenko Oleksiy Pogrebnyak 《Color research and application》2017,42(2):156-172
In this article, we present an adaptive color similarity function defined in a modified hue‐saturation‐intensity color space, which can be used directly as a metric to obtain pixel‐wise segmentation of color images among other applications. The color information of every pixel is integrated as a unit by an adaptive similarity function thus avoiding color information scattering. As a direct application we present an efficient interactive, supervised color segmentation method with linear complexity respect to the number of pixels of the input image. The process has three steps: (1) Manual selection of few pixels in a sample of the color to be segmented. (2) Automatic generation of the so called color similarity image (CSI), which is a gray level image with all the gray level tonalities associated with the selected color. (3) Automatic threshold of the CSI to obtain the final segmentation. The proposed technique is direct, simple and computationally inexpensive. The evaluation of the efficiency of the color segmentation method is presented showing good performance in all cases of study. A comparative study is made between the behavior of the proposed method and two comparable segmentation techniques in color images using (1) the Euclidean metric of the a* and b* color channels rejecting L* and (2) a probabilistic approach on a* and b* in the CIE L*a*b* color space. Our testing system can be used either to explore the behavior of a similarity function (or metric) in different color spaces or to explore different metrics (or similarity functions) in the same color space. It was obtained from the results that the color parameters a* and b* are not independent of the luminance parameter L* as one might initially assume in the CIE L*a*b* color space. We show that our solution improves the quality of the proposed color segmentation technique and its quick result is significant with respect to other solutions found in the literature. The method also gives a good performance in low chromaticity, gray level and low contrast images. © 2016 Wiley Periodicals, Inc. Col Res Appl, 42, 156–172, 2017 相似文献
986.
Danfeng Liu Liguo Wang Jón Atli Benediktsson 《International journal of remote sensing》2017,38(4):1062-1082
Data visualization can accelerate data processing so that enormous quantities of data can be utilized effectively. Visualization of data can achieve image communication between people and data as well as between people to help observers get information hidden in data, providing a tool for discovery and understanding of scientific law. To solve the problem of multi-image and multi-modality image display in the field of remote sensing, an interactive colour visualization method for hyperspectral imagery (HSI) is proposed in this article. This method visualizes complex information of original HSI data through different fusion results of multiple images in a colour space, which is under the interactive control of the observers. By gradually determining predetermined points, observers can obtain a relatively satisfying image blending mode, output an image with clearer interested target, and obtain the corresponding mixing coefficient of images. The proposed method can also solve the problem that traditional visualization methods only display information from three bands in one image, and conduct information mining in HSI with a certain purpose based on the demands of users. In addition, this approach is also applicable for visualization of other types of multi-modal imagery. 相似文献
987.
988.
989.
Ionene Hydrogels: Synergistic Computational‐Experimental Approach to Improve Ionene Polymer‐Based Functional Hydrogels (Adv. Funct. Mater. 31/2014)
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990.
Ana M. Herrera-González Martín Caldera-Villalobos Jesús García-Serrano Marissa Vargas Ramírez Azdrubal Lobo Guerrero-Serrano 《Designed Monomers and Polymers》2018,21(1):137-144
In this paper we report the synthesis of a new polyacrylate named poly(1,1?-BP4MA) which is a derivate from 4-biphenylmethanol monomer. Poly(1,1?-BP4MA) was obtained by solution and bulk polymerization techniques to yield polymers with high molecular weight and high solubility. The study of the optical properties showed that poly(1,1?-BP4MA) is a fluorescent material with emission in the UV-green region and it has similar quantum yield to tryptophan. 相似文献