Maternal Prenatal Inflammation Increases Brain Damage Susceptibility of Lipopolysaccharide in Adult Rat Offspring via COX-2/PGD-2/DPs Pathway Activation

A growing body of research suggests that inflammatory insult contributes to the etiology of central nervous system diseases, such as depression, Alzheimer’s disease, and so forth. However, the effect of prenatal systemic inflammation exposure on offspring brain development and cerebral susceptibility to inflammatory insult remains unknown. In this study, we utilized the prenatal inflammatory insult model in vivo and the neuronal damage model in vitro. The results obtained show that prenatal maternal inflammation exacerbates LPS-induced memory impairment, neuronal necrosis, brain inflammatory response, and significantly increases protein expressions of COX-2, DP2, APP, and Aβ, while obviously decreasing that of DP1 and the exploratory behaviors of offspring rats. Meloxicam significantly inhibited memory impairment, neuronal necrosis, oxidative stress, and inflammatory response, and down-regulated the expressions of APP, Aβ, COX-2, and DP2, whereas significantly increased exploring behaviors and the expression of DP1 in vivo. Collectively, these findings suggested that maternal inflammation could cause offspring suffering from inflammatory and behavioral disorders and increase the susceptibility of offspring to cerebral pathological factors, accompanied by COX-2/PGD-2/DPs pathway activation, which could be ameliorated significantly by COX-2 inhibitor meloxicam treatment.     

动载滑动轴承瞬态油膜的全景实验研究

在搭建的滑动轴承实验台上,对大扰动工况下油膜全景空穴分布图像及油膜压力进行瞬态同步采集,并对图像进行后处理,以便于观察并与基于质量守恒边界条件的理论仿真结果对比,并对同一旋转周期内油膜空穴分布和不同工况下油膜压力进行对比分析。结果表明：油膜全景图像经过后处理转化为油膜原形展开图像后,图像直观,且更易于对比分析;在大扰动工况下,油膜空穴区域随最大动偏心位置迁移而迁移。     

基于压力槽可调谐长周期光纤光栅模块的设计

提出一种基于机械微弯变形法的能够同时生成不同谐振波长的多个长周期光纤光栅的制作方案.仿真分析了该方案中各参数(如光栅有效长度、倾斜角度以及外界应力)变化对长周期光纤光栅损耗峰深度和谐振波长的影响.结果显示,长周期光纤光栅的损耗峰深度主要受光栅有效长度和压力影响,而倾斜角度大幅度改变谐振波长位置.     

抗氧剂1010的晶型分析

利用差示扫描量热分析(DSC)、红外光谱(IR)、粉末X射线衍射(XRD)等手段对抗氧剂1010样品进行了晶体结构分析。不同方法各有特点,分析结果应是几种方法的相互印证与归纳统一。     

四川盆地老气田二次开发优化技术及应用

经过近60年的开发,四川盆地的许多老气田已进入低压、低产的开发中后期,部分气田虽然已濒临废弃,但其中仍尚存较多剩余天然气资源未采出。通过梳理分析,认为具备二次开发条件的气田多存在地层水活跃形成水封难以解封、低渗透储量难动用等问题。为此,从老气田二次开发的定义出发,全面阐述了其技术路线及优选条件:(1)在建立缝洞系统多储渗体模式的基础上,采用压力重整曲线进行地质模型正演、生产动态反演特征曲线诊断,提出了复杂岩溶缝洞系统多储渗体识别及定量描述方法,结合U型管气水赋存新模式,形成了强水侵多缝洞系统天然气储量计算新技术;(2)建立孔、洞、缝三重介质数值模型,形成强水侵底水缝洞气藏"水平井排水+直井采气"排采井网模拟及效果评价新技术;(3)依托精细气藏描述形成的配套集成技术,重构气藏地质模型,分类评价气藏低渗透储量,结合井网优化、水平井地质导向、分段酸化压裂等工艺技术,进一步提高有效动用率;(4)建立多节点、多环节输气管网模型,形成区域性管网整体模拟优化及预测技术。实施效果表明,该二次开发技术在老气田产能建设、提高老气田采收率、延缓老气田产量递减、稳定老气田产量等方面均具有明显成效。     

羊角山之造化

我国有悠久的饮茶历史,饮茶时所需的饮茶用具亦渊远流长,随着时代的进步,越来越考究,自北宋以来,人们尤以紫砂茶具著称为首,这种爱好,一直沿传至今。     

Glass crystallization making red phosphor for high-power warm white lighting

Rapid development of solid-state lighting technology requires new materials with highly efficient and stable luminescence, and especially relies on blue light p...     

Insights into the Reaction Network and Mechanism of Green Aerobic Oxidative Esterification of Methacrolein over Different Heterogeneous Catalysts

The oxidative esterification of methacrolein (MAL) is an important way to prepare high-valued methyl methacrylate (MMA), but this process is ultra-complex due t...     

我国钢管混凝土拱桥应用现状与展望

以轴压比、含钢率和钢材强度为参数,进行了8根高强钢管超高强混凝土柱和1根普通强度钢管超高强混凝土对比柱的拟静力试验,分析了各参数对破坏形态、荷载-位移滞回曲线、骨架曲线和各个抗震性能指标(如延性、耗能和强度与刚度退化等)的影响程度。结果表明：压弯破坏为主要破坏模式;弹性刚度受轴压比影响不大,但受含钢率和钢材强度影响较大;极限承载力受轴压比、含钢率和钢材强度影响较大,随前者增大而降低,随后两者增大而增大;延性受轴压比、钢材强度和含钢率影响较大,随前两者增大降低,随后者增大而增大;耗能能力随轴压比增大而减弱,随含钢率和钢材强度增大而增强;刚度和强度退化程度随轴压比增大而降低,随含钢率增大而增大,且前者随钢材强度增大而增大,后者则随钢材强度增大呈减小趋势。通过对比不同规程抗弯刚度计算方法,结果表明：受材料适用范围限制,各规程不适用于该类高强材料组合构件。