State of the Art: The Immunomodulatory Role of MSCs for Osteoarthritis

Osteoarthritis (OA) has generally been introduced as a degenerative disease; however, it has recently been understood as a low-grade chronic inflammatory process that could promote symptoms and accelerate the progression of OA. Current treatment strategies, including corticosteroid injections, have no impact on the OA disease progression. Mesenchymal stem cells (MSCs) based therapy seem to be in the spotlight as a disease-modifying treatment because this strategy provides enlarged anti-inflammatory and chondroprotective effects. Currently, bone marrow, adipose derived, synovium-derived, and Wharton’s jelly-derived MSCs are the most widely used types of MSCs in the cartilage engineering. MSCs exert immunomodulatory, immunosuppressive, antiapoptotic, and chondrogenic effects mainly by paracrine effect. Because MSCs disappear from the tissue quickly after administration, recently, MSCs-derived exosomes received the focus for the next-generation treatment strategy for OA. MSCs-derived exosomes contain a variety of miRNAs. Exosomal miRNAs have a critical role in cartilage regeneration by immunomodulatory function such as promoting chondrocyte proliferation, matrix secretion, and subsiding inflammation. In the future, a personalized exosome can be packaged with ideal miRNA and proteins for chondrogenesis by enriching techniques. In addition, the target specific exosomes could be a gamechanger for OA. However, we should consider the off-target side effects due to multiple gene targets of miRNA.     

Liutex identification on hairpin vortex structures in a channel based on msfle and moving-PIV

The spatiotemporal evolution of hairpin vortex structures in a fully developed turbulent boundary layer is investigated qualitatively and quantitatively by usin...     

Thermal Contact Resistance between Aero Engine Compressor Blade and Flexible Fixture

In the process of two-pass micro plasma arc welding of titanium alloy sheet,based on the thermal contact resistance theory,a three-dimensional transient heat tr...     

Photorhabdus luminescens TccC3 Toxin Targets the Dynamic Population of F-Actin and Impairs Cell Cortex Integrity

Due to its essential role in cellular processes, actin is a common target for bacterial toxins. One such toxin, TccC3, is an effector domain of the ABC-toxin produced by entomopathogenic bacteria of Photorhabdus spp. Unlike other actin-targeting toxins, TccC3 uniquely ADP-ribosylates actin at Thr-148, resulting in the formation of actin aggregates and inhibition of phagocytosis. It has been shown that the fully modified F-actin is resistant to depolymerization by cofilin and gelsolin, but their effects on partially modified actin were not explored. We found that only F-actin unprotected by tropomyosin is the physiological TccC3 substrate. Yet, ADP-ribosylated G-actin can be produced upon cofilin-accelerated F-actin depolymerization, which was only mildly inhibited in partially modified actin. The affinity of TccC3-ADP-ribosylated G-actin for profilin and thymosin-β4 was weakened moderately but sufficiently to potentiate spontaneous polymerization in their presence. Interestingly, the Arp2/3-mediated nucleation was also potentiated by T148-ADP-ribosylation. Notably, even partially modified actin showed reduced bundling by plastins and α-actinin. In agreement with the role of these and other tandem calponin-homology domain actin organizers in the assembly of the cortical actin network, TccC3 induced intense membrane blebbing in cultured cells. Overall, our data suggest that TccC3 imposes a complex action on the cytoskeleton by affecting F-actin nucleation, recycling, and interaction with actin-binding proteins involved in the integration of actin filaments with each other and cellular elements.     

关于高等数学教学改革的几点意见

对现行高等数学教学中存在的一些突出问题,提出改革措施.     

小容量电器微小触头的磁力去毛刺技术

小容量电器微小触头的磁力去毛刺工艺是在磁场的作用下、利用磁性磨料形成的的柔性磁刷,对触头相应表面产生一定的碰撞、滚压、滑擦、刻划,实现触头表面的抛光和去毛刺。采用ANSYS对磁路进行了分析和设计,对磨粒与工件进行了受力及运动分析,建立了磁力研磨试验平台,进行了相应的工艺性实验。试验结果表明,磁力研磨技术对触点的抛光作用明显,并能有效去除触头毛刺。     

20 辊轧机主液压系统污染控制的研究

根据液压系统污染控制理论,建立了２０辊轧机主液压系统控制污染的数学模型。     

ZSF合金抗钻性及复合韧化效果

研究了ＺＳＦ合金的显微组织及其抗钻削性和冲击韧性。结果表明,ＺＳＦ合金的显微组织是奥氏体＋共晶碳化物。该组织的硬度虽不很高（３５ＨＲＣ）却具有很强的抗钻削能力,其主要机制是钻削时加工硬化引起部分奥氏体转变成马氏体。该合金单体结构冲击韧性较低,与韧性好的Ｑ２３５Ａ钢焊接复合后抗冲击能力可明显提高。     

Yb_2O_3纳米晶的制备及其若干性质的研究

用溶胶 -凝胶法制备了不同粒径的 Yb2 O3纳米晶。XRD分析表明 :所合成的 Yb2 O3纳米晶属于立方晶系 ,空间群为 Ia3。TEM分析表明 :所合成的 Yb2 O3粒子基本呈球形。计算表明 :Yb2 O3的平均晶粒度随焙烧温度的升高而增大 ,而平均晶格畸变率随焙烧温度的升高和晶粒度的增大而减小 ,表明晶粒越小 ,晶格畸变越大 ,微晶发育越不完整。溶解性试验表明 :Yb2 O3晶粒度减小 ,表面活性增加。FTIR光谱分析表明 :纳米 Yb2 O3比普通的 Yb2 O3具有更高的表面活性 ,Yb- O键的吸收强度减弱 ,有微小的蓝移。