定量构效关系研究中分子描述符的相关性

分子描述符的计算是定量构效关系(QSAR)研究的基础,也是化学计量学研究的重要内容,在药物化学、环境科学等领域应用广泛。目前可计算的各种分子描述符已超过4 000种,如何选择合适的分子描述符,成为QSAR研究中首先要做的事。本文首先综述了分子描述符的研究进展,然后随机选择10 000余个化合物,利用Cerius2、Sybyl、Dragon软件计算1 600多种分子描述符,最后,采用相关分析和聚类分析研究各描述符之间的关系,相关分析表明,各类分子描述符之间存在较强的线性关系,这种关系通过聚类分析可以直观体现。     

高速公路雾天通行保障与导航系统研究

高速公路雾天行车存在着严重的安全隐患,针对雾天能见度低对高速公路产生的影响,提出了一种新颖的、行之有效的解决方法,并且实现了其主体部分的功能.     

远程移动办公无线接入的安全分析和对策研究

文章通过对远程移动办公无线接入安全问题的深入分析,引申出在设计远程移动办公安全方案中的对策研究:远程移动办公无线接入仅靠数字证书的认证机制是远远不够的,还应对其它相关安全方面进行综合考虑,才能真正实现远程移动办公自由方便的同时,最大限度消除其对内网的安全隐患。     

SPSS统计软件中的因子分析法在医学科研中的应用

首先介绍了因子分析理论及分析步骤,然后,通过举例介绍了如何利用SPSS来完成对健康人生化检查结果的因子分析,根据分析出的结果进行评价,以确定检验人是否健康的最适标准的模型。     

基于ARM和MiniGUI的呼气式酒精测试仪研究

设计了一种以ARM7微控制器LPC2210为核心的燃料电池型呼气式酒精测试仪;该仪器在LPC2210上移植嵌入式操作系统uClinux,利用燃料电池传感器的输出电压与酒精浓度的相关性,通过采集燃料电池传感器中酒精气体反应产生的模拟信号计算出酒精浓度;详细介绍了燃料电池传感器的电化学原理,及在ARM-Linux嵌入式操作系统环境下,利用轻量级的图形用户界面支持系统MiniGUI进行软件界面开发的方法,提高了人机交互友好性和易操作性;实验表明,该酒精测试仪具有稳定性好、精度高、抗干扰性强的明显优点。     

Computational simulation of Belousov–Zhabotinskii oscillating chemical reaction

The suitability of computational simulation of the Belousov–Zhabotinskii oscillating chemical reaction by differential kinetic methodology for resolving nonlinear multi-component system is demonstrated in this work. According to the Field–KÖrÖs–Noyes mechanism and the Oregonator model, the change of the concentrations of HBrO₂, bromide ion and cerium ion are simulated. The results of computational simulation are consistent with experimental results very well. At the same time, the effect of variables and parameters, especially the rate constant on the oscillation curve, are investigated deeply. A simple method of estimating rate constants is obtained through simulation the concentrations of key components of the system, and then comparison the simulation results with the experimental ones. The reasonable rate constant is also proposed.     

A Y-channel design for improving zeta potential and surface conductivity measurements using the current monitoring method

This study presents a new Y-channel design for measuring the zeta potential and surface conductance of a solid-liquid pairing using the current monitoring technique. The new design improves the throughput and reliability of the testing apparatus since the displacement between two solutions can be repeated many times without interfering with the experiments. It also increases the accuracy of the measurement by producing sharper start and end transitions for the current–time plot of the solution displacement process. In this design, efforts have been made to minimize the effects of electrolysis, Joule heating and undesired pressure driven flow on the measurements. An improvement on the current–time slope analysis is also presented. The Y-channel design was validated by comparing zeta potential measurements to published results. The zeta potential of several biological buffers relevant to the microfluidic community in plasma treated PDMS/PDMS and PDMS/Glass microchannels are presented. Preliminary studies of surface conductivity measurements using the Y-channel design were also conducted and are briefly discussed.     

Efficient identity-based GQ multisignatures

ISO/IEC 14888 specifies a variety of digital signature mechanisms to sign messages of arbitrary length. These schemes can be applied to provide entity authentication, data origin authentication, non-repudiation, and data integrity verification. ISO/IEC 14888 consists of three parts under the general title Information technology—Security techniques—Digital signatures. Part II, or ISO/IEC 14888-2 specifies the general structure and the fundamental procedures for the generation and verification of an identity-based signature (IBS) mechanism for messages of arbitrary length. Particularly, the IBS scheme of Guillou and Quisquater (GQ) is described in Clauses 6–8. In this paper, an efficient identity-based multisignature (IBMS) scheme is proposed for the GQ IBS scheme, which allows multiple users using the ISO/IEC 14888-2 standard GQ scheme to generate multisignatures. The scheme is efficient in the sense that both the length and the verification time of the multisignatures are fixed. The proposed ID-based multisignature scheme is also secure against forgeability under adaptive chosen-message attack and adaptive chosen-identity attack in random oracle model.     

图像边缘检测在DM642上的应用研究

采用TMS320DM642EVM作为数字图像处理硬件平台,利用CCS开发环境来构建程序并对其进行优化;通过对改进后的Log算子和小波多尺度方法提取到的边缘图像进行数据融合,得到一幅新的边缘图像。实验结果表明,该方法提高了边缘检测的运算速度,满足了实时性要求;并能有效地抑制噪声的影响,保留了图像边缘细节。     

Immunoglobulin 1 (IgG1) Fc-glycosylation profiling of anti-citrullinated peptide antibodies from human serum

In several autoimmune disorders, including rheumatoid arthritis (RA), autoantibodies are thought to be the driving force of pathogenicity. Glycosylation of the Fc-part of human Igs is known to modulate biological activity. Hitherto, glycosylation of human IgG-Fc has been analyzed predominantly at the level of total serum IgG, revealing reduced galactosylation in RA. Given the pathogenic relevance of autoantibodies in RA, we wished, in the present study, to address the question whether distinct Fc-glycosylation features are observable at the level of antigen-specific IgG subpopulations. For this purpose, we have developed a method for the microscale purification and Fc-glycosylation analysis of anti-citrullinated peptide antibodies (ACPA). ACPA represent a group of autoantibodies that occur with unique specificity in RA patients. Their presence is associated with increased inflammatory disease activity and rapid joint destruction. Results indicate that ACPA of the IgG1 subclass vary considerably from total serum IgG1 with respect to Fc-galactosylation, with galactosylation being higher on ACPA than on serum IgG1 for some patients, while other patients show higher galactosylation on serum IgG1 than on ACPA. Using this method, studies can be performed on the biological and clinical relevance of ACPA glycosylation within RA patient cohorts.