Transdermal Absorption of Zidovudine from Ethanol-Isopropyl Myristate Mixed System and Influence of Probenecid on It in Rats

Transdermal absorption of zidovudine (AZT) from an ethanol-isopropyl myristate (IPM) mixed system was examined in rats. For comparison of bioavailability (BA) after topical applications, 0.25 ml of the ethanol/IPM system containing 40% ethanol and 60 mM AZT was applied as a standard formulation. Values of the area under the plasma concentration-time curves of AZT for 8 hr (AUC_0-8), as indices of BA, following application of various formulations were compared with that of the standard formulation. Then the influence of content of the drug and ethanol, and application volume of the system was evaluated. BA was effectively improved only when the total amount of ethanol applied on the skin was increased. On the other hand, simultaneous transdermal application of AZT and probenecid increased the AU_0-8, of AZT without necessitating the increase in ethanol content in the formulation. In addition, coadministered probenecid improved cerebrospinal fluid/plasma concentration ratio of AZT.     

Fluidised pellet bed bioreactor: a promising technology for onsite wastewater treatment and reuse.

A pilot-scale fluidised pellet bed (FPB) bioreactor, which combines chemical coagulation, biological degradation, particle pelletisation and separation in one unit, was applied for onsite wastewater treatment and reuse. As a result of rational use of inorganic coagulant and organic polymer and moderate mechanical agitation, spherical particles were generated in the upflow column and a well-fluidised bed was formed. With a continuous supply of dissolved oxygen through a recycling loop, an aerobic condition was kept in the bottom section of the FPB column. Under such conditions the pellets in the FPB column showed the following characteristics: (1) compact structure and high density; (2) rich in microorganisms; and (3) high MLSS and MLVSS concentrations. Therefore, the FPB bioreactor achieved more than 90% removal of SS, COD, BOD and TP from raw domestic wastewater within a total hydraulic retention time (HRT) of only about 30 minutes. It also showed nitrification and denitrification ability and the TN removal could be about 50% as the recycling ratio was increased to 1:1. The treated water quality is generally competitive with the secondary effluent from a conventional activated sludge process. With these advantages the FPB bioreactor is recommendable as a compact system for onsite wastewater treatment and reuse.     

Anaerobic digestion of alkaline black liquor using an up-flow anaerobic sludge blanket reactor

The anaerobic digestion of alkaline black liquor from a cereal straw pulping mill was studied in batch (serum bottles) and continuous systems (up-flow anaerobic sludge blanket reactor—UASB). The batch digestion studies confirmed that lignin and related compounds (LRC) in the alkaline black liquor were the main inhibitory substances and could not be decomposed by anaerobic bacteria. At organic loading rates of 5–10 kg COD m^?3 day^?1, the UASB reactor achieved 50–60% COD removal efficiencies. Gas production was 2–3 dm³ per dm³ of alkaline black liquor. Two different sludge types were examined in the reactor: granular and cluster-like sludges. Sludge in a cluster, which involved many small granules and flocs, tended to form larger aggregates and possessed good settling ability.     

温度,压力对漂移室气体增益的影响

研究了温度及气体压力对漂移室（工作于正比区）气体放大倍数的影响，温度和气体压力的变化范围分别是５￣４０℃及９０￣１０５ｋＰａ。用实验数据拟合得到了函数关系并测量了几种饱和度下函数中的参数值。     

岩石样品中铷的中子活化分析

研究了苦味酸溶液的ｐＨ变化对用１８－Ｃ－６（１８Ｃ６）的硝基苯溶液定量萃取Ｒｂ的影响及１８Ｃ６浓度变化对定量萃取Ｒｂ的影响，确定了定量反萃Ｒｂ的实验条件。作出了磷酸锆无机离子交换柱上的Ｒｂ－Ｃｓ分离曲线。测定了岩石样品的微量Ｒｂ和痕量＾８４Ｒｂ。     

Analysis of emerging technology adoption for the digital content market

The digital content market is undergoing an evolution in networking and digitalization technologies, offering diverse information and services. Due to the characteristics of these emerging technologies, the digital content market is growing rapidly and traditional content providers face service transformation decisions. While a majority of the previous technology adoption studies have focused on the viewpoints of users and customers, cost reduction, or electronic channel related technologies, in this research we analyze the emerging technology adoption decisions of competing firms for providing new content services from a strategic perspective. Utilizing game theoretical models, we examine the effects of market environments (technology cost, channel cannibalization, brand power, brand extension, information asymmetry and market uncertainty) on firms’ adoption decisions. This research contributes a number of unique and interesting implications for the issues of emerging technology adoption for new content service provision.     

Adaptive synchronization of master-slave large-scale systems against bias actuators and network attenuations

This paper utilizes the adaptive technique to design a class of active synchronizing masterslave large scale systems against imperfect actuators and networked interconnections with bias faults and signal attenuations, respectively. Without the requirement of knowledge of eventual faulty factors of bias-actuators on systems, and attenuation factors of connected networks, an adaptive mechanism is designed to estimate each unknown faulty factor on-line for constructing a class of distributed adaptive controllers. Then based on the adaptive adjustment parameters and Lyapunov stability theory, Lyapunov functions are addressed to prove that the proposed adaptive master-slave large-scale system can be guaranteed to be asymptotic synchronization with the improper actuator and faulty transmitted signals. Finally, a multiple vehicle large-scale system is used to verify the efficiency of the method.     

Preparation and properties of close-packed composite materials

Monodisperse silica particles of about 0.3m diameter are suspended in methacrylate monomer using a carefully selected dispersant. Many steric dispersants are hydrocarbon chains with a reactive end-group. These are not effective as dispersants for silica in moderately polar solvents, such as esters and the methacrylate monomers. Good dispersion was obtained with a methacrylate polymer terminated by a chlorosilane end group. Settling or centrifugation of these unagglomerated dispersions gives well-packed particle beds. Polymerization of the surrounding monomer produces composite materials with high packing fractions and a high degree of regularity. Moduli and strengths of these composites are reported.     

基于Visual Basic 开发机床主传动非常规变速系统的设计--重复转速的传动系统(实例之二)

本文介绍利用Visual Basic工具开发金属切削机床主传动非常规变速系统的设计总体结构，功能和方法，以重复转速的传动系统为例，重点介绍转速图的拟定过程，本系统具有界面美观，操作方便，易于理解的特点。     

不同活化剂对石油焦基活性炭孔结构的影响

以石油焦为原料 ,Na OH,KOH和 Na2 CO3 为活化剂制备活性炭 ,采用氮气吸附考察了不同活化剂对活性炭的比表面积、中孔和微孔孔径分布、孔容积及平均孔径等孔结构的影响 .结果表明 :KOH活化制备的活性炭包含 1 nm的微孔和 4nm的中孔 ,总孔容 0 .648cm3 /g,比表面积大 ;Na OH制备的活性炭以 1 nm的微孔为主 ,占总孔容 ( 0 .1 65 cm3 /g)的 98% ,平均孔径 1 .83nm;Na2 CO3 制备的活性炭以 4nm的中孔为主 ,占总孔容 ( 0 .1 43cm3 /g)的 68.5 % ,平均孔径 3.42 nm,比表面积小 .3种样品的孔径都呈现出多峰分布特征 .KOH和 Na2 CO3 活化制备的活性炭的 N2 吸附脱附曲线属于 型 ,Na OH活化制备的活性炭吸附脱附曲线属于 型 .