A Multifunctional and Fast-Response Lysosome-Targetable Fluorescent Probe for Monitoring pH and Isoxaflutole

A new chemosensor, namely N-(2-morpholinoethyl)acetamide-4-morpholine-1,8-naphthimide (MMN), was designed and synthesized through an amidation reaction. MMN was fabricated as a multifunctional fluorescent probe for monitoring pH and isoxaflutole. MMN exhibited excellent stability in MeCN/H₂O (v/v, 9/1), with an obvious “off–on” fluorescence response toward pH changes due to intramolecular charge transfer (ICT), where the linear response ranges of MMN in the weakly acidic system were from 4.2 to 5.0 and from 5.0 to 6.0 with apparent pK_a = 4.62 ± 0.02 and 5.43 ± 0.02. Based on morpholine as the lysosome targetable unit, MMN could selectively locate lysosomes in live cells. MMN also successfully detected the presence of H⁺ in test papers. Finally, MMN could specifically recognize isoxaflutole at a detection limit of 0.88 μM. A possible sensing mechanism was identified based on density function theory calculations. These results indicate that MMN could be a superior potential chemosensor for detecting pH and isoxaflutole selectively and sensitively and could be used in real sample detection.     

Strength,strain capacity and toughness of five dual-phase pipeline steels

The effect of microstructures on strength, strain capacity and low temperature toughness of a micro-alloyed pipeline steel was elucidated. Five various dual-pha...     

Factors Associated with White Fat Browning: New Regulators of Lipid Metabolism

Mammalian adipose tissue can be divided into white and brown adipose tissue based on its colour, location, and cellular structure. Certain conditions, such as sympathetic nerve excitement, can induce the white adipose adipocytes into a new type of adipocytes, known as beige adipocytes. The process, leading to the conversion of white adipocytes into beige adipocytes, is called white fat browning. The dynamic balance between white and beige adipocytes is closely related to the body’s metabolic homeostasis. Studying the signal transduction pathways of the white fat browning might provide novel ideas for the treatment of obesity and alleviation of obesity-related glucose and lipid metabolism disorders. This article aimed to provide an overview of recent advances in understanding white fat browning and the role of BAT in lipid metabolism.     

岩石切削过程中破坏机制的离散元分析

利用离散单元方法(DEM)对两种不同属性的花岗石样本模型进行了切割模拟,通过调整不同的切削参数计算并分析了岩石切削过程中的切削力、切削深度、切削比能及切削力倾角的变化规律,从细观上探讨了临界切深对岩石脆性破坏模式和塑性破坏模式及其转变的影响,指出了当切削深度逐渐增大时,破坏模式依次从塑性破坏模式到过渡破坏模式最后转变为脆性破坏模式,同时切削力倾角并不随切削深度变化。将离散单元法分析的结果与实际实验进行了比较,表明该方法是合理的。     

基于风险的检验在乙烯分离单元中的应用

分离单元是乙烯装置的一个重要组成部分,通过应用基于风险的检验方法,对乙烯装置分离单元中的设备和管道进行了风险评估,分析了该单元中主要的失效模式和损伤机理.通过失效概率和失效后果的计算,确定各设备的风险等级,并根据风险结果,提出降低风险措施,制定优化检验策略,为装置的定期检验提供了参考和依据.     

铁基稳定化材料在重金属污染土壤修复中的应用

土壤重金属污染形势日益严峻,严重影响人类身体健康。铁基稳定化材料可有效稳定土壤重金属。本文从稳定化机理、材料理化性质等方面对铁基稳定化材料进行了介绍,并在最后对实际工程案例进行了分析。希望为铁基稳定化材料在土壤重金属稳定化领域的应用提供有用信息。     

Γ形框架对初始缺陷敏感性的非线性屈曲分析

结合工程实例,利用ANSYS有限元软件,对优化设计后的Γ形框架进行非线性屈曲分析。计算五种工况,得出重要结论:该种结构屈曲后性能不稳定,对初始缺陷敏感,跨中初始负位移有利于屈曲后承载力上升,跨中初始正位移导致屈曲后承载力急剧下降,在工程设计及安装施工中应予以足够的重视。     

Recent Advances in Application of Computer-Aided Drug Design in Anti-Influenza A Virus Drug Discovery

Influenza A is an acute respiratory infectious disease caused by the influenza A virus, which seriously threatens global human health and causes substantial economic losses every year. With the emergence of new viral strains, anti-influenza drugs remain the most effective treatment for influenza A. Research on traditional, innovative small-molecule drugs faces many challenges, while computer-aided drug design (CADD) offers opportunities for the rapid and effective development of innovative drugs. This literature review describes the general process of CADD, the viral proteins that play an essential role in the life cycle of the influenza A virus and can be used as therapeutic targets for anti-influenza drugs, and examples of drug screening of viral target proteins by applying the CADD approach. Finally, the main limitations of current CADD strategies in anti-influenza drug discovery and the field’s future directions are discussed.     

基于有限样本的大气偏振模式生成方法

大气偏振模式在导航等领域具有广阔的应用前景,但是由于受到大气偏振信息采集装置物理特性的限制,在同一时刻只能获得局部的、不连续的偏振信息,对实际应用产生影响。针对此问题,本文通过挖掘大气偏振模式分布的连续性,提出一种大气偏振模式生成方法,从局部的偏振信息生成全天域的大气偏振模式。此外,偏振信息往往受到不同的天气条件、地理环境等因素的影响,而这些偏振数据在真实环境中难以采集。针对此问题,本文挖掘不同天气、地理条件下有限样本数据之间的多样性关系,以此关系将生成的大气偏振模式泛化到不同的条件下。本论文在仿真数据和实测数据上进行了实验,并与其它最新方法进行对比,实验结果证明了本文方法的优越性和鲁棒性。