An analytical model for water-oil two-phase flow in inorganic nanopores in shale oil reservoirs

The existence of water phase occupies oil flow area and impacts the confined oil flow behavior at the solid substrate in inorganic nanopores of shale oil reserv...     

生态学视角下我国建筑陶瓷行业发展趋势研究

我国建筑陶瓷产量已连续15年保持世界第一,但其成长的极限在哪里?本文用Malthusian模型和logistic 模型对我国过去20年的建陶生产情况进行了分析,然后根据生态学相关理论,对我国建陶的未来发展趋势进行了分析和判断,最后绘制了我国建陶未来发展趋势曲线,并对其中可能出现的情况进行了分析.     

多类型围护结构及混合支撑在深基坑施工中的应用

在工期紧、施工场地狭小等条件的约束情况下,深基坑的围护支撑体系采用了部分钢筋混凝土支撑 部分钢支撑的形式,提高了围护结构整体刚度和稳定性,并降低了支护结构造价,节约了成本,且保证了打桩及挖土施工的顺利进行.     

人民防空地下室中柴油电站的电气设计

依据《人民防空地下室设计规范》,总结了柴油电站的设计原则;分别阐述了固定柴油电站(区域电站)和移动柴油电站的机组容量,台数的确定,柴油电站的布置及设计深度要求。     

软土地区建筑基坑无撑开挖探讨

以上海地区常见的住宅小区车库基坑开挖实例分析无撑开挖的可行性.强调要在对基地土质和周边环境充分认知的情况下,辅以围护加强或边坡强化,按"时空效应"挖土和严密的信息化监挖是实现无撑开挖的前提条件.     

冲击压实技术在旧有沥青结构道路改造中的应用

结合某省道旧有沥青结构道路改造采用的冲击压实技术,结合一系列实测结果,介绍了冲击压路机冲击压实机理,探讨并建议了在不同道路病害成因的情况下,冲击压路机型号选择、冲压效果的检测标准确定、冲压效果的评定以及相关注意事项,具有一定的参考价值。     

耐火钢与普通结构钢高温强度的比较试验

对两种耐火钢(FR)与普通结构钢在常温到高温700℃之间的力学性能比较试验研究结果显示,耐火钢比普通结构钢具有更好的高温力学性能,耐火钢在约650℃时的屈服强度为常温下强度的50%,而普通结构钢在550℃时的屈服强度就已降到常温下强度的50%。同时耐火钢的高温(600℃)蠕变也比普通结构钢的小。研究结果表明在建筑设计中用耐火钢替代需要采取防火措施的普通结构钢更经济安全。     

BIM在铁路四电工程的适应性分析

目前的BIM应用与各种新兴信息技术相结合,在多领域均有其身影,而铁路四电工程因其多专业交叉、施工难、跨自然区域大等特点,迫切地需要BIM来提高设计、施工的效率。为使BIM在铁路四电工程中更好地应用,分析了应用中出现的问题,并提出解决对策,为BIM在铁路四电工程中的实际应用提供一定参考。     

基于IFC认证的BIM建模软件选择方案研究

近年来,国内外对BIM技术在建筑行业中的应用越来越重视,BIM已成为未来建筑行业技术的发展趋势。作为BIM实施的第一步,BIM模型的创建对BIM的成功应用和推广具有重要的意义。IFC数据标准作为国际通用的BIM基础数据格式,可以使以IFC标准格式形成的BIM模型,在多种AEC工程软件中进行信息传递及交换。当前,不同的软件对IFC格式的支持范围及支持程度各不相同。本文针对BuildingSMART的Coordination View Certification 2.0项目中对当前主流BIM软件的IFC2X3支持情况的统计,进行了整理与分析,得出面向IFC的BIM建模软件选择方案,为不同特点的项目BIM应用提供软件参考,从而促进IFC标准的发展以及BIM技术的普及。     

Endogenous Modulation of Extracellular Matrix Collagen during Scar Formation after Myocardial Infarction

Myocardial infarction is remains the leading cause of death in developed countries. Recent data show that the composition of the extracellular matrix might differ despite similar heart function and infarction sizes. Because collagen is the main component of the extracellular matrix, we hypothesized that changes in inflammatory cell recruitment influence the synthesis of different collagen subtypes in myofibroblasts, thus changing the composition of the scar. We found that neutrophils sustain the proliferation of fibroblasts, remodeling, differentiation, migration and inflammation, predominantly by IL-1 and PPARγ pathways (n = 3). They also significantly inhibit the mRNA expression of fibrillar collagen, maintaining a reduced stiffness in isolated myofibroblasts (n = 4–5). Reducing the neutrophil infiltration in CCR1^−/− resulted in increased mRNA expression of collagen 11, moderate expression of collagen 19 and low expression of collagen 13 and 26 in the scar 4 weeks post infarction compared with other groups (n = 3). Mononuclear cells increased the synthesis of all collagen subtypes and upregulated the NF-kB, angiotensin II and PPARδ pathways (n = 3). They increased the synthesis of collagen subtypes 1, 3, 5, 16 and 23 but reduced the expression of collagens 5 and 16 (n = 3). CCR2^−/− scar tissue showed higher levels of collagen 13 (n = 3), in association with a significant reduction in stiffness (n = 4–5). Upregulation of the inflammation-related genes in myofibroblasts mostly modulated the fibrillar collagen subtypes, with less effect on the FACIT, network-forming and globular subtypes (n = 3). The upregulation of proliferation and differentiation genes in myofibroblasts seemed to be associated only with the fibrillar collagen subtype, whereas angiogenesis-related genes are associated with fibrillar, network-forming and multiplexin subtypes. In conclusion, although we intend for our findings to deepen the understanding of the mechanism of healing after myocardial infarction and scar formation, the process of collagen synthesis is highly complex, and further intensive investigation is needed to put together all the missing puzzle pieces in this still incipient knowledge process.