Torsion sensor based on two cascaded long period fiber gratings fabricated by CO2 laser pulse irradiation and HF etching technique respectively

A novel torsion sensor is proposed, which is composed of one long period fibre grating and one asymmetrically corrugated long period fibre grating based on the high-frequency CO₂ laser pulses technology and burning fibre coating and etching cladding technology, respectively. By combing the advantages of the two aforementioned elements, a sensitivity of 331.7 and 310.3 pm/(rad/m) towards clockwise and anticlockwise direction, respectively, is reached in the experiments.     

用核糖体工程技术二次开发海洋微生物菌株资源的研究

经对无活性的海洋来源放线菌B3054进行链霉素抗性筛选,获得了一株具有抗肿瘤活性的链霉素抗性突变株SY-1.从该突变株的发酵物中分离得到了4个活性化合物,其中1个为新天然产物.对该菌株突变前后的rpsL基因(编码核糖体蛋白S12)进行分析未发现发生突变,提示突变位点可能在核糖体的另外亚基上.实验结果表明,核糖体工程技术可用于无活性菌株资源的二次开发利用.     

Synthesis, characterization and osteoconductivity properties of bone fillers based on alendronate-loaded poly(ε-caprolactone)/hydroxyapatite microspheres

A superior drug controlled release system capable of achieving efficient osteogenesis is in imperative demand because of limited bone substitute tissue for the treatment of bone defect. In the present study, we investigated the potential of using poly(ε-caprolactone)–hydroxyapatite (PCL–HA) composite microspheres as an injectable bone repair vehicle by controlled release of alendronate (AL), a medicine that belongs to the bisphosphonates family. The PCL/HA–AL microspheres were prepared with solid/oil/water emulsion technique, which included two processes: (1) AL was loaded on the hydroxyapatite nanoparticles; (2) the HA–AL complex was built in the PCL matrix. The spherical PCL/HA–AL microspheres were characterized with its significantly improved encapsulation efficiency of hydrophilic AL and better sustained release. Human bone mesenchymal stem cells (hMSCs) were cultured on the surface of these microspheres and exhibited high proliferative profile. Specifically, in osteogenic medium, hMSCs on the surface of PCL/HA–AL microspheres displayed superior osteogenic differentiation which was verified by alkaline phosphatase activity assay. In conclusion, by presenting strong osteogenic commitment of hMSCs in vitro, the PCL/HA–AL microspheres have the potential to be used as an injectable vehicle for local therapy of bone defect.     

规整填料在5 Mt/a常减压装置减压塔提馏段中的应用

介绍了新型规整填料Zugrid 64 X和Zupak125 Y在中国石油兰州石化分公司5 Mt/a常减压装置减压塔提馏段的工业应用情况.运行结果表明,新型规整填料具有明显的节能降耗优势,分离效果好,渣油中500 ℃以下的馏分质量分数仅为2.58%,且蒸汽用量较低[m(蒸汽)/m(渣油)为9 kg/t],操作成本低,抗堵塞性能良好.     

cPCN-Regulated SnO2 Composites Enables Perovskite Solar Cell with Efficiency Beyond 23％

Efficient electron transport layers(ETLs)not only play a crucial role in promoting carrier separation and electron extraction in perovskite solar cells(PSCs)but...     

Processing,Quality,Safety,and Acceptance of Meat Analogue Products

Rapid global population growth has caused an increasing need for products containing protein.Meat products are the most common high-protein food source,but impa...     

动载滑动轴承瞬态油膜的全景实验研究

在搭建的滑动轴承实验台上,对大扰动工况下油膜全景空穴分布图像及油膜压力进行瞬态同步采集,并对图像进行后处理,以便于观察并与基于质量守恒边界条件的理论仿真结果对比,并对同一旋转周期内油膜空穴分布和不同工况下油膜压力进行对比分析。结果表明：油膜全景图像经过后处理转化为油膜原形展开图像后,图像直观,且更易于对比分析;在大扰动工况下,油膜空穴区域随最大动偏心位置迁移而迁移。     

Development of gated fiber detectors for laser-induced strong electromagnetic pulse environments

With the development of laser technologies,nuclear reactions can happen in high-temperature plasma environments induced by lasers and have attracted a lot of at...     

虚拟环境中三维CAD模型数据优化及重组

三维CAD在虚拟环境中有着广泛的应用,其模型数据由于具有复杂的结构且拥有较多的冗余信息而不能高效的运用到虚拟环境的构建中。基于此,针对虚拟场景渲染对数据模型的要求,给出了三维CAD模型数据优化及重组方法,该方法能去除冗余信息,优化文件结构,丰富数据内容,且能够有效地提高虚拟环境的绘制效率。     

Unkeito Suppresses RANKL-Mediated Osteoclastogenesis via the Blimp1–Bcl6 and NF-κB Signaling Pathways and Enhancing Osteoclast Apoptosis

Osteoporosis is a common bone disease, particularly in menopausal women. Herein, we screened four Kampo medicines (Unkeito (UKT), Kamishoyosan (KSS), Kamikihito (KKT), and Ninjinyoeito (NYT)), frequently used to treat menopausal syndromes, for their effects on receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast differentiation in RAW 264 cells. Considering that UKT exhibited the most potent effect, we examined its effect on RANKL-induced osteoclastogenesis, the induction of osteoclast apoptosis, and the mechanisms underlying its effects. UKT inhibits RANKL-induced osteoclast differentiation in the early stage and decreases osteoclast-related genes, including tartrate-resistant acid phosphatase (Trap), dendritic cell-specific transmembrane protein (Dcstamp), matrix metalloproteinase-9 (Mmp9), and cathepsin K (Ctsk). Specifically, UKT inhibits the nuclear factor of activated T cells 1 (NFATc1), which is essential for osteoclastogenesis. UKT increases Bcl6, which antagonizes NFATc1 and Dc-stamp, thereby blocking the progression of osteoclasts to maturation. UKT also decreased nuclear translocation by downregulating the activity of p65/NF-κB. In addition, UKT enhances mononuclear osteoclast apoptosis via activation of caspase-3. Herein, we demonstrate that UKT suppresses RANKL-mediated osteoclastogenesis via the Blimp1–Bcl6 and NF-κB signaling pathways and enhances mononuclear osteoclast apoptosis. Furthermore, UKT prevents bone loss in OVX mice. Thus, UKT might be a potential therapeutic agent for postmenopausal osteoporosis.