Tumor necrosis factor-alpha production enhancing activity of substituted 3'-methylthalidomide: influence of substituents at the phthaloyl moiety on the activity and stereoselectivity

The synthesis and tumor necrosis factor (TNF)-alpha production enhancing activity of substituted 3'-methylthalidomides on human leukemia cell line HL-60 stimulated with 12-O-tetradecanoyl-phorbol 13-acetate (TPA) are described. Though the introduction of an electron-donating amino group at the phthaloyl moiety of alpha-methylthalidomides enhanced the activity, substituted alpha-methylthalidomides showed decreased stereoselectivity as compared to that of non-substituted alpha-methylthalidomide. The data indicates that the TNF-alpha production enhancing activity of thalidomide derivatives depends on both the electronic-state of substituents at the fused benzene ring and the stereochemistry of the glutarimide moiety.     

Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export

The DBP5 gene encodes a putative RNA helicase of unknown function in the yeast Saccharomyces cerevisiae. It is shown here that Dbp5p is an ATP-dependent RNA helicase required for polyadenylated [poly(A)+] RNA export. Surprisingly, Dbp5p is present predominantly, if not exclusively, in the cytoplasm, and is highly enriched around the nuclear envelope. This observation raises the possibility that Dbp5p may play a role in unloading or remodeling messenger RNA particles (mRNPs) upon arrival in the cytoplasm and in coupling mRNP export and translation. The functions of Dbp5p are likely to be conserved, since its potential homologues can be found in a variety of eukaryotic cells.     

新疆东昆仑地区金矿成矿地质条件及找矿方向初探

东昆仑地区是昆仑巨型成矿带中２个重要的成矿区之一，从大地构造背景、沉积建造、岩浆活动等成矿地质条件的分析入手，对东昆仑地区的求勉雷克成矿远景区、鸭子泉成矿远景区、库木巴彦成矿远景区和石雪尖成矿远景区的金矿成矿条件进行了初步的探讨，指出了找矿方向。     

Health-promoting behaviors of rural adolescent women

A part of a larger study of the health behaviors of adolescent women, this investigation examined health-promoting behaviors and the influence of cognitive, social, and environmental factors on these health-promoting behaviors of rural adolescent women. The sample consisted of 128 rural African-American and white adolescent women. Forty-four percent of the variance in health-promoting behavior of this sample was explained by five variables: self-image, problem solving, mother's education, employment status, and family structure. Self-image was the most salient predictor of health-promoting behavior, explaining 33% of the variance.     

PC／ABS合金的研制及其在汽车上的应用

对ＰＣ／ＡＢＳ合金开发和研制及其在汽车上的应用作了评述。介绍了上海杰事公司在该领域的进展。     

三峡工程左厂房坝导墙抗震计算分析

 用反应谱理论对三峡左厂房坝导墙3种典型设计断面型式进行了抗震计算分析比较，得出了其自振特性及地震动位移、动应力响应。对选定的设计断面型式Ⅲ进行了抗拉应力强度安全性评价。     

程控交换机收号系统模拟的研究

本文提出了一种模拟程控交换机收号系统的有效方法,采用消息驱动收号事件表的思想,运用并发控制技术,实现了在没有话路硬设备的条件下多用户同时拨号在线模拟收号控制的功能。本文提出的收号系统模拟方案已成功应用于某国产中大容量程控交换机的呼叫模拟系统中。     

Genomic imprinting and carcinogenesis

The solution structure of a synthetic ET(B) selective agonist, ET-1[Cys(Acm)(1,15), Ala3, Leu7, dAsp8, Aib11] has been solved by 1H NMR and molecular modelling studies. Such solution structures of linear modified peptides in aqueous methanol are being used in an ongoing program of research designed to assist in an understanding of the basic structural requirements for the biological activity of vasoconstrictors. The resulting structure of this peptide is characterised by an alpha-helical conformation between residues Leu6-His16 and by N- and C-termini which assume no defined conformation. A knowledge of the solution structures of this and related peptides, which are ET(B) selective agonists, are proving to be important in the understanding of how they interact with the ET(B) receptor.     

氯化氢浸渍活性炭净化汞蒸气的研究

用氯化氢对吸附汞热气用的活性炭进行浸渍处理是一种新的偿试。用氯化氢浸渍后的活性炭，对汞的吸附效率和吸附容量与没有浸渍的活性炭相比，均有很大的提高，同时，与其它吸附汞用的浸渍剂相比，具有价格低，来源广的优点，对汞的吸附效率平均在９５％以上。     

衰减曲线分析的诺模图

基于Arps递减方程,建立了衰减曲线分析的诺模图。应用该诺模图,可以方便地确定油气田的可采储量。