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A mammalian genetic system to screen for small molecules capable of disrupting protein-protein interactions 总被引:2,自引:0,他引:2
Zhao HF Kiyota T Chowdhury S Purisima E Banville D Konishi Y Shen SH 《Analytical chemistry》2004,76(10):2922-2927
A mammalian two-hybrid system was developed for high-throughput screening of compounds that disrupt specific protein-protein interactions. The existing mammalian systems are unsatisfactory for drug screening due to nonregulated expression of interacting proteins. To construct a tightly regulated system, the tetracycline repressor was fused with the inhibitory KRAB domain as a suppressor. The binding of the suppressor to the tet operator entirely blocked expression of two interacting proteins. When both the inducer doxycycline and drugs were added to the culture, the reporter gene was either activated by interaction of the paired proteins with ineffective drugs or remained silent due to disruption of the protein interactions by the effective drugs. We demonstrate that interactions of the type I receptor for TGFbeta with FKBP12 and the epidermal growth factor receptor (EGFR) with p85 are effectively disrupted by FK506 and EGFR kinase inhibitor AG1478, respectively. The power of this system for drug screening was further demonstrated by rapid identification of inhibitors from a druglike library for the receptor kinases. 相似文献
84.
Kitamura Y Shogenji R Yamada K Miyatake S Miyamoto M Morimoto T Masaki Y Kondou N Miyazaki D Tanida J Ichioka Y 《Applied optics》2004,43(8):1719-1727
The authors have proposed an architecture for a compact image-capturing system called TOMBO (thin observation module by bound optics), which uses compound-eye imaging for a compact hardware configuration [Appl. Opt. 40, 1806 (2001)]. The captured compound image is decomposed into a set of unit images, then the pixels in the unit images are processed with digital processing to retrieve the target image. A new method for high-resolution image reconstruction, called a pixel rearrange method, is proposed. The relation between the target object and the captured signals is estimated and utilized to rearrange the original pixel information. Experimental results show the effectiveness of the proposed method. In the experimental TOMBO system, the resolution obtained is four times higher than that of the unit image that did not undergo reconstruction processing. 相似文献
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Internal oxidation was observed in gold-rich alloys as substrates for porcelain veneers in dental restorations, which contain small amounts of Fe and Sn. The internal oxidation proceeded with oxygen ions diffusing to the inner part of the alloy through Fe2O3 formed at the grain boundaries of the alloy matrix. SnO2 was formed internally together with the Fe2O3. The external oxidation zone was composed of only Fe2O3 in a wide range of Fe and Sn concentrations. Fe3O4 was formed with Fe2O3 in the Sn-rich composition range by reduction of Fe2O3 in the presence of Sn. A band mainly composed of SnO2 was formed at the inside of the internal oxidation zone in the composition range where Fe3O4 formed. In the Sn-rich alloys this internal oxidation band of SnO2 moved to the external oxidation zone. 相似文献
88.
Yasuo Harayama 《Nuclear Engineering and Design》1974,31(1):66-71
The effect of radially asymmetric heat generation on the temperature and heat flux distribution in a fuel rod is evaluated. Based on practical assumptions, the temperature distribution in power reactor fuel can be obtained between reasonable limits by solving the steady-state heat conduction equation with asymmetric heat generation. 相似文献
89.
Remineralization effects of xylitol on demineralized enamel 总被引:3,自引:0,他引:3
We morphologically determined the effects of xylitol on the remineralization of artificially demineralized enamel. The samples were demineralized and then immersed in a remineralizing solution with or without 20% xylitol at 37 degrees C for 2 weeks. Samples were observed using contact microradiography, a multipurpose image processor (MIP) and a high-resolution electron microscope (HRTEM). Contact microradiography indicated that remineralization occurred in the surface and deep layers of samples immersed in a non-xylitol solution. Samples immersed in a xylitol solution demonstrated less mineralization in the outer 10 microm of the outermost surface layers, but more mineralization in the middle and deep layers, than was observed in the non-xylitol samples. The MIP evaluation indicated that remineralization was more prominent in layers at depths of 50-60 microm in the xylitol samples than in the non-xylitol samples. Observation of the xylitol samples by HRTEM revealed crystals of various sizes and irregular shapes with unclear crystal angles in the outermost surface layers. In the middle layers, they had thickened and angles of crystals are clear. These results indicate that xylitol can induce remineralization of deeper layers of demineralized enamel by facilitating Ca2+ movement and accessibility. 相似文献
90.
Mode analysis of spreading of partially coherent beams propagating through atmospheric turbulence 总被引:11,自引:0,他引:11
Shirai T Dogariu A Wolf E 《Journal of the Optical Society of America. A, Optics, image science, and vision》2003,20(6):1094-1102
The spreading of partially coherent beams propagating through atmospheric turbulence is studied by use of the coherent-mode representation of the beams. Specifically, we consider partially coherent Gaussian Schell-model beams entering the atmosphere, and we examine the spreading of each coherent mode, represented by a Hermite-Gaussian function, on propagation. We find that in atmospheric turbulence the relative spreading of higher-order modes is smaller than that of lower-order modes, whereas the relative spreading of all order modes is the same as in free space. This modal behavior successfully explains why under certain circumstances partially coherent beams are less affected by atmospheric turbulence than are fully spatially coherent laser beams. 相似文献