Effect of stents coated with a combination of sirolimus and alpha-lipoic acid in a porcine coronary restenosis model

The aim of this study was to evaluate antiproliferative sirolimus- and antioxidative alpha-lipoic acid (ALA)-eluting stents using biodegradable polymer [poly-l-lactic acid (PLA)] in a porcine coronary overstretch restenosis model. Forty coronary arteries of 20 pigs were randomized into four groups in which the coronary arteries had a bare metal stent (BMS, n = 10), ALA-eluting stent with PLA (AES, n = 10), sirolimus-eluting stent with PLA (SES, n = 10), or sirolimus- and ALA-eluting stent with PLA (SAS, n = 10). A histopathological analysis was performed 28 days after the stenting. The ALA and sirolimus released slowly over 30 days. There were no significant differences between groups in the injury or inflammation score; however, there were significant differences in the percent area of stenosis (56.2 ± 11.78 % in BMS vs. 51.5 ± 12.20 % in AES vs. 34.7 ± 7.23 % in SES vs. 28.7 ± 7.30 % in SAS, P < 0.0001) and fibrin score [1.0 (range 1.0–1.0) in BMS vs. 1.0 (range 1.0–1.0) in AES vs. 2.0 (range 2.0–2.0) in SES vs. 2.0 (range 2.0–2.0) in SAS, P < 0.0001] between the four groups. The percent area of stenosis based on micro-computed tomography corresponded with the restenosis rates based on histopathological stenosis in different proportions in the four groups (54.8 ± 7.88 % in BMS vs. 50.4 ± 14.87 % in AES vs. 34.5 ± 7.22 % in SES vs. 28.9 ± 7.22 % in SAS, P < 0.05). SAS showed a better neointimal inhibitory effect than BMS, AES, and SES at 1 month after stenting in a porcine coronary restenosis model. Therefore, SAS with PLA can be a useful drug combination for coronary stent coating to suppress neointimal hyperplasia.     

Quantitative Proteomics Study Reveals Changes in the Molecular Landscape of Human Embryonic Stem Cells with Impaired Stem Cell Differentiation upon Exposure to Titanium Dioxide Nanoparticles

The increasing number of nanoparticles (NPs) being used in various industries has led to growing concerns of potential hazards that NP exposure can incur on human health. However, its global effects on humans and the underlying mechanisms are not systemically studied. Human embryonic stem cells (hESCs), with the ability to differentiate to any cell types, provide a unique system to assess cellular, developmental, and functional toxicity in vitro within a single system highly relevant to human physiology. Here, the quantitative proteomics approach is adopted to evaluate the molecular consequences of titanium dioxide NPs (TiO₂ NPs) exposure in hESCs. The study identifies ≈328 unique proteins significantly affected by TiO₂ NPs exposure. Proteomics analysis highlights that TiO₂ NPs can induce DNA damage, elevated oxidative stress, apoptotic responses, and cellular differentiation. Furthermore, in vivo analysis demonstrates remarkable reduction in the ability of hESCs in teratoma formation after TiO₂ NPs exposure, suggesting impaired pluripotency. Subsequently, it is found that TiO₂ NPs can disrupt hESC mesoderm differentiation into cardiomyocytes. The study unveils comprehensive changes in the molecular landscape of hESCs by TiO₂ NPs and identifies the impact which TiO₂ NPs can have on the pluripotency and differentiation properties of human stem cells.     

An adaptive load balancing management technique for RFID middleware systems

In recent years, Radio Frequency Identification (RFID) industries have taken a great interest in utilizing the benefits of RFID for supply chain management, inventory control and various other applications. This paper proposed an adaptive load balancing technique for RFID middleware systems to meet the demands of scalability and heterogeneity. First, we explored five basic load balancing policies, namely, information policy, job selection policy, transfer policy, initiation policy and location policy. Eighteen load balancing schemes were then proposed for RFID middleware systems that were combinations of various types of the five basic load balancing policies. Our empirical study suggested that these load balancing strategies performed differently under different workload statuses. Finally, an adaptive load balancing strategy was proposed. The load balancing schemes and the proposed adaptive load balancing strategy have been implemented in the RFID Middleware Load Management System (RM‐LMS). Copyright © 2010 John Wiley & Sons, Ltd.     

A new vertical‐alignment LC mode with high‐transmittance and fast‐response‐time features

Abstract— A novel pixel design for vertical‐alignment LCDs with superior transmittance has been developed. The new liquid‐crystal mode, refered to as the hole‐induced vertical‐alignment mode (Hi‐VA), uses a via hole of an organic layer on a TFT substrate to achieve multi‐domain alignment. Compared to the conventional design, the Hi‐VA mode has a transmittance of up to 135% with a contrast ratio of 2000:1. Moreover, the new structure is free from ITO patterning or protrusion on the color‐filter side, which makes the fabrication process simple and low cost.     

Disturbance decoupled fault reconstruction using sliding mode observers

This paper investigates and presents conditions that guarantee disturbance decoupled fault reconstruction using sliding mode observers, which are less stringent than those of previous work, and show that disturbance reconstruction is not necessary. An aircraft model validates the ideas proposed in this paper. Copyright © 2010 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society     

Individual,social, and organizational contexts for active knowledge sharing in communities of practice

Firms that have implemented knowledge management initiatives are now interested in nurturing voluntary knowledge sharing organizations, called communities of practice (CoPs). Adopting the Triandis model on attitude formation, we identified and validated a set of organizational factors that was anticipated to have effects on knowledge sharing by CoP members such as perceived consequences, affect, social factors and facilitating conditions. One hundred and seventy-nine members from 70 CoPs of a large multinational electronics firm participated in this survey. Based on the PLS analysis, perceived consequences, affect, social factors, and facilitating conditions were found to significantly affect knowledge sharing in CoPs.     

Quart-parametric interpolations for intersecting paths

The intersecting path is an important tool path generation method. This paper proposes an approach for the quart-parametric interpolation of intersecting paths. The objective of our approach is that the intersecting paths for surface machining can be directly interpolated within the computer numerical control (CNC) system. This enables the CNC interpolator to process the intersecting paths without geometric approximation as in existing approaches and take into consideration any specific feedrate profiles and further machining dynamical issues along the path.The interpolation of the intersection of two general parametric surfaces is transferred into interpolation of its projection curves and the time trajectories of four parameters along the intersecting curves are obtained. Our strategy is to carry out the quart-parametric interpolation based on the projection interpolation. The feedrate control method is developed, and then the interpolation algorithms for two projection curves are proposed. An error reduction scheme is presented to alleviate point deviation from the drive parametric surface. Simulations of quart-parametric interpolation have been carried out to verify the effectiveness of the proposed algorithm.     

Ontology-based mobile augmented reality in cultural heritage sites: information modeling and user study

Augmented reality (AR) has received much attention in the cultural heritage domain as an interactive medium for requesting and accessing information regarding heritage sites. In this study, we developed a mobile AR system based on Semantic Web technology to provide contextual information about cultural heritage sites. Most location-based AR systems are designed to present simple information about a point of interest (POI), but the proposed system offers information related to various aspects of cultural heritage, both tangible and intangible, linked to the POI. This is achieved via an information modeling framework where a cultural heritage ontology is used to aggregate heterogeneous data and semantically connect them with each other. We extracted cultural heritage data from five web databases and modeled contextual information for a target heritage site (Injeongjeon Hall and its vicinity in Changdeokgung Palace in South Korea) using the selected ontology. We then implemented a mobile AR application and conducted a user study to assess the learning and engagement impacts of the proposed system. We found that the application provides an agreeable user experience in terms of its affective, cognitive, and operative features. The results of our analysis showed that specific usage patterns were significant with regard to learning outcomes. Finally, we explored how the study’s key findings can provide practical design guidance for system designers to enhance mobile AR information systems for heritage sites, and to show system designers how to support particular usage patterns in order to accommodate specific user experiences better.

     

Team THOR's Entry in the DARPA Robotics Challenge Finals 2015

This paper describes Team THOR's approach to human‐in‐the‐loop disaster response robotics for the 2015 DARPA Robotics Challenge (DRC) Finals. Under the duress of unpredictable networking and terrain, fluid operator interactions and dynamic disturbance rejection become major concerns for effective teleoperation. We present a humanoid robot designed to effectively traverse a disaster environment while allowing for a wide range of manipulation abilities. To complement the robot hardware, a hierarchical software foundation implements network strategies that provide real‐time feedback to an operator under restricted bandwidth using layered user interfaces. Our strategy for humanoid locomotion includes a backward‐facing knee configuration paired with specialized toe and heel lifting strategies that allow the robot to traverse difficult surfaces while rejecting external perturbations. With an upper body planner that encodes operator preferences, predictable motion plans are executed in unforeseen circumstances. These plans are critical for manipulation in unknown environments. Our approach was validated during the DRC Finals competition, where Team THOR scored three points in 18 min of operation time, and the results are presented along with an analysis of each task.