创建无泄漏工厂节能降耗

铸轧分厂在争创“无泄漏工厂”活动中,首先抓思想教育,提高职工的认识水平;强化内部管理,明确责任范围,具体落实到班组;建立各种规章制度,并且依靠科技进步,挖掘节能潜力,通过小改小革治理泄漏,取得了显著经济效益。     

SLIDING VECTOR DESIGN BASED ON THE POLE‐ASSIGNMENT METHOD

This paper mainly focuses on the sliding vector design based on the poleassignment method. Unlike the general sliding vector design, the poleassignment method is applied to the overall system, not to a reduced system in sliding mode. Funrthermore, because four important conditions are considered, this sliding vector design is much simpler and more straightforward. Finally, a numeric example is included to demonstrate the validity of the proposed technique.     

纳米/微米复合二氧化钛改性聚氨酯涂层的耐腐蚀性能研究

以微米/纳米二氧化钛(TiO2)为复合填料制备了聚氨酯防腐涂层,采用电化学阻抗谱(EIS)评估含不同用量纳米TiO2涂层在0.5mol/L氯化钠溶液中的耐腐蚀性,结果表明,纳米二氧化钛能有效提高涂层的抗腐蚀能力,其适宜用量为1.0%～1.5%。热分析(包括DSC和TG)结果表明,在有大尺度填料存在的条件下,添加纳米二氧化钛对涂层的热稳定性影响不大。     

Comparison of the structural and functional effects of monomeric and dimeric human apolipoprotein A-II in high density lipoprotein particles

High density lipoprotein (HDL) is throught to play a significant role in the process of reverse cholesterol transport. It has become clear that the apolipoprotein (apo) composition of HDL is important in determining the metabolic fate of this particle. The major proteins of human HDL are apoAI and APOAII; the latter protein is a disulfide-linked dimer in humans and higher primates but monomeric in the other species. The consequences of the apo Cys6-Cys6 disulfide bridge in apoAII for human HDL structure and function are not known. To address this issue, the influence of the Cys6-Cys6 disulfide bridge on the interaction of human apoAII with palmitoyl-oleoyl phosphatidylcholine has been studied. The size and valence of a series of homogeneous discoidal complexes containing either monomeric (reduced and carboxymethylated) or dimeric apoAII have been determined, and their ability to remove cholesterol from rat Fu5AH hepatoma cells grown in culture has been compared. The apoAII dimer and monomer form discoidal complexes of similar size, with twice as many of the latter molecule required per disc. Removal of the disulfide bond influences the stability of the helical segments around the edge of the disc as seen by a decrease in α-helix content of the monomeric protein. The discoidal particles containing the monomeric form of apoAII are somewhat more effective than particles containing either dimeric apoAII or apoAI in removing cellular cholesterol. Overall, reduction of the disulfide bridge of apoAII probably does not have a major effect in the determination of HDL particle sizein vivo. It follows that the evolution of the Cys6-Cys6 disulfide bond in higher primates probably has not had a major effect on the function of the apoAII molecule.     

用实验设计分析法确定高压液压软管接头总成优化扣压的控制模式

高压液压软管接头总成是液压行业的基础件之一,它的质量直接影响到液压系统及其主机的可靠性。目前国内液压附件行业,对此已得到普遍的重视,作为行业的共同问题而急待解决。本文在多因素实验设计与分析的基础上,得出影响扣压质量的主要因素及其它们的参数的优化组合,并对此拟定了相应的实验装置得出他们在扣压过程中的变化规律和相互关系。实验结果为理论分析打下基础,并弥补了理论分析的局限性,从而确定了实现优化扣压的最佳控制模式。     

Identification of a novel secretogranin II-derived peptide (SgII(187-252)) in adult and fetal human adrenal glands using antibodies raised against the human recombinant peptide

Molecular cloning of secretogranin II (SgII) in phylogenetically distant species has recently revealed the existence of a highly conserved 66-amino acid peptide flanked by preserved pairs of basic residues. This observation suggested that this peptide, named EM66, which had not been described to date, could be an important processing product of SgII. The aim of the present study was to investigate the possible occurrence of EM66 in the human adrenal gland. The EM66 peptide was generated in Escherichia coli, which was programmed to make a fusion protein containing the human EM66 sequence. The affinity-purified fusion protein was used to raise polyclonal antibodies in rabbits. The free EM66 peptide was obtained by cleavage of the fusion protein followed by high performance liquid chromatography purification. Immunohistochemical analysis using the EM66 antibodies revealed intense labeling of adrenochromaffin cells in the adult adrenal medulla and the fetal adrenal gland. A sensitive and specific RIA was developed and applied to the detection of EM66-like immunoreactivity in extracts of adult adrenal medulla and whole fetal adrenal gland after high performance liquid chromatographic analysis. A major immunoreactive species exhibiting the same retention time as recombinant EM66 was detected in both adult and fetal adrenal extracts. Taken together, these data demonstrate that posttranslational processing of SgII actually generates EM66 in the adrenal gland. The strong conservation of the amino acid sequence of EM66 in the vertebrate phylum and the occurrence of the mature peptide in both fetal and adult chromaffin cells suggest that EM66 could play an important physiological role in the human adrenal gland.     

Wetting behaviour and mullite formation at the interface of inviscid melt-spun CaO-Al2O3 fibre-reinforced Al-Si alloy (4032) composite

Inviscid melt-spun calcia-alumina fibre-reinforced aluminium-silicon alloy (4032) composites were produced using a melt-infiltration technique. Scanning electron microscopy, energy dispersive X-ray spectroscopy (EDS), and X-ray diffraction (XRD) were used to investigate interfacial wetting and interphase formation, and identify the crystalline phase of the interphase of these composites. The composites processed at 700°C showed a good interfacial wetting and silicon accumulation at the interface. The composites processed at 927°C showed formation of an interphase region of about 10–20 m thick, as well as excellent interfacial wetting. EDS analysis gave averaged compositions of this interphase region at 74 wt % Al and 26 wt % Si, which corresponds to the composition of mullite (3Al₂O₃ · 2SiO₂). The formation of mullite at the interface was confirmed by XRD analysis.     

Molecular Mechanisms of Retinal Pigment Epithelium Dysfunction in Age-Related Macular Degeneration

The retinal pigment epithelium (RPE), situated upon Bruch’s membrane, plays multiple roles in the ocular system by interacting with photoreceptors and. Therefore, dysfunction of the RPE causes diseases related to vision loss, such as age-related macular degeneration (AMD). Despite AMD being a global cause of blindness, the pathogenesis remains unclear. Understanding the pathogenesis of AMD is the first step for its prevention and treatment. This review summarizes the common pathways of RPE dysfunction and their effect in AMD. Potential treatment strategies for AMD based on targeting the RPE have also been discussed.     

浅谈建筑合同风险的防范

从合同订立、合同履行以及产生合同纠纷以后等几个方面论述了可能产生合同风险的情形以及预防风险的对策。同时指出,坚持诚信原则,充分认识合同的严肃性,认真履约,是预防合同纠纷的关键。     

棉籽蛋白粉的生物脱毒研究

以选育的ＦＢ－２－８菌株［１］,在５４℃±１℃按１０％接种量,将棉籽蛋白粉进行固态厌氧发酵４８ｈ。结果：棉籽蛋白粉中总棉酚被脱毒８０％～９０％,游离棉酚含量＜０．０１％,粗蛋白含量无明显变化,蛋白质中各氨基酸的比例未变。