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101.
102.
Deokho Lee Yohei Tomita Yukihiro Miwa Heonuk Jeong Ari Shinojima Norimitsu Ban Shintaro Yamaguchi Ken Nishioka Kazuno Negishi Jun Yoshino Toshihide Kurihara 《International journal of molecular sciences》2022,23(23)
Cardiovascular abnormality-mediated retinal ischemia causes severe visual impairment. Retinal ischemia is involved in enormous pathological processes including oxidative stress, reactive gliosis, and retinal functional deficits. Thus, maintaining retinal function by modulating those pathological processes may prevent or protect against vision loss. Over the decades, nicotinamide mononucleotide (NMN), a crucial nicotinamide adenine dinucleotide (NAD+) intermediate, has been nominated as a promising therapeutic target in retinal diseases. Nonetheless, a protective effect of NMN has not been examined in cardiovascular diseases-induced retinal ischemia. In our study, we aimed to investigate its promising effect of NMN in the ischemic retina of a murine model of carotid artery occlusion. After surgical unilateral common carotid artery occlusion (UCCAO) in adult male C57BL/6 mice, NMN (500 mg/kg/day) was intraperitoneally injected to mice every day until the end of experiments. Electroretinography and biomolecular assays were utilized to measure ocular functional and further molecular alterations in the retina. We found that UCCAO-induced retinal dysfunction was suppressed, pathological gliosis was reduced, retinal NAD+ levels were preserved, and the expression of an antioxidant molecule (nuclear factor erythroid-2-related factor 2; Nrf2) was upregulated by consecutive administration of NMN. Our present outcomes first suggest a promising NMN therapy for the suppression of cardiovascular diseases-mediated retinal ischemic dysfunction. 相似文献
103.
焊缝熔宽动态实时检测研究 总被引:2,自引:0,他引:2
本文以通过焊接熔池中心的红外扫描横向温度场为根据,提出了一种新颖的焊缝熔宽动态实时检测装置,其检测数据可通过显示、打印系统,进行监视、记录,亦可直接送入微型计算机实现熔宽自适应控制。 相似文献
104.
105.
K Takeshita S Furui S Ban A Harasawa H Kohtake T Yamauchi Y Sasaki T Shirai Y Kikuchi 《Canadian Metallurgical Quarterly》1996,56(11):744-746
Helical computed tomography was performed with intravenous contrast material administration in ten patients with hepatic tumors (metastatic tumor, n = 6; hepatocellular carcinoma, n = 4). Maximum intensity projection (MIP) images of intrahepatic portal venous branches and hepatic veins, and shaded surface display (SSD) images of the hepatic tumors were reconstructed for each patient. The MIP image and SSD image were fitted to overlap on a single display to obtain three-dimensional (3-D) images showing both the hepatic vessels and hepatic tumors. Subsegmental localization of the tumors determined from the 3-D images proved to be correct in all of the six patients who received hepatic resection after examination. 3-D images seem to be useful for preoperative assessment of hepatic tumors. 相似文献
106.
107.
As the use of PTCA (Percutaneous Transluminal Coronary Angioplasty) is progressively widespread, the indication of CABG (Coronary Artery Bypass Grafting) and its candidates are changing accordingly. At present the candidates for CABG have left main trunk disease or severe triple-vessel disease, which are difficult or too dangerous to undergo PTCA. We should also note the population of operative candidates is becoming gradually older than before. The results from CABG appear to be limited according to the random follow-up studies in Europe and United States. The recurrence of angina and myocardial infarction tends to happen after five years. Our follow-up study shows the same tendency as those studies abroad. In order to improve the long-term results of CABG, we recommend the use of arterial grafts such as internal mammary artery, opt to the complete revascularization, and follow the patients postoperatively maximum medical therapy. At the same time, we should stress the importance of deciding the best operative opportunity, and not hesitate to make the decision for reoperation if it became necessary. Older candidates have tendency to suffer from neurological or respiratory complications during the postoperative period. If the risk of those complications appears great from the preoperative examination, we must make efforts to prevent those complications and finish CABG in the shortest possible time. Recently the cases for emergent CABG are decreasing for unstable angina or acute myocardial infarction, because PTCA is more effective for a short time. Time appears to be the most limiting factor for emergent coronary revascularization. Therefore the indication of emergent CABG is left only for left main trunk disease or severe triple vessel disease with complete occlusion of two coronary vessels. As a conclusion, CABG should be considered as only a palliative therapy same as PTCA and other medical treatments. Therefore the treatment of ischemic heart disease must be constituted by a integrated strategy including PTCA and drug therapy arranged for each patient. 相似文献
108.
Calcium phosphates were deposited on a pure titanium plate for various loading times under 1.3 and 12.9 mA/cm2 in a modified simulated body fluid at 52-92 degrees C. The plate-like crystals formed under 1.3 mA/cm2 were identified to be octacalcium phosphate (OCP) and/or carbonate-containing apatite. OCP converted to carbonate-containing apatite with the elapsing time of the loading current. The needle-like precipitates formed under 12.9 mA/cm2 were identified to be carbonate-containing apatite crystals elongated parallel to the c-axis direction. The degrees of crystallinity of the deposits formed under 1.3 mA/cm2 showed the highest value around 72 degrees C, whereas those under 12.9 mA/cm2 increased with the electrolyte temperature. The carbonate content of the deposits decreased with the electrolyte temperature and the flow current. The degree of crystallinity of the electrochemically deposited calcium phosphates decreased with the carbonate content. 相似文献
109.
Research studies of symmetrical spiral inductors for silicon technology have become very important and challenging. In this article, we attempt to give a detailed explanation of how symmetrical spiral inductors help to improve the quality factor (Q) as compared to conventional nonsymmetrical inductors. The experimental results are presented to verify our theory. © 2005 Wiley Periodicals, Inc. Int J RF and Microwave CAE, 2005. 相似文献
110.
Rate adaptive video transmission over ad-hoc networks 总被引:2,自引:0,他引:2
A packet control mechanism via a cross-layer feedback to reduce bursts of packet drops for transmission of video over mobile multihop ad-hoc networks is presented. With this approach, the application layer would be capable of controlling the packet transmission flow in accordance with the multihop characteristics of the routing layer. 相似文献