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31.
Toshiro Matsui Xiao-Lin Zhu Koso Shiraishi Tatsuro Ueki Yoshiharu Noda Kiyoshi Matsumoto 《Journal of food science》2010,75(4):H129-H134
ABSTRACT: In this study, we focused on the antihypertensive effect of newly fermented salt-free soy sauce (SFS) in spontaneously hypertensive rats (SHRs). A 13-wk oral administration of SFS was performed daily in 8- to 21-wk-old SHRs with a dose of 200 mg/kg of body weight/d. The systolic (SBP) and diastolic (DBP) blood pressures were measured for each week during the experimental period. As a result, a significant (P < 0.01) BP lowering effect was observed from the 5th d to the end of the experiment in the SFS group compared with the control group (ΔSBP21-wk: 27 mmHg, ΔDBP21-wk: 20 mmHg). In contrast to such substantial effect by SFS intake, angiotensin I-converting enzyme activities in blood and local organs as well as pharmaceutical parameters such as serum Na+ or K+ level did not show any significant difference between in both SFS and control groups. Vasoconstriction experiment using thoracic aorta rings from 21-wk SHRs provided an interesting result that the rings from the SFS group evoked a >2-fold higher increase in the angiotensin II-stimulated constrictive response compared with the rings from the control group (P = 0.012), which suggested that the SFS-intake would be effective in possessing a higher vessel tone. Practical Application: In this study, we investigated the antihypertensive effect of newly fermented SFS in SHRs. As a result of 13-wk SFS-administration, we found a significant antihypertensive effect of the SFS. This finding strongly demonstrates that the developed SFS would be greatly beneficial for health and useful for health-related industries. 相似文献
32.
33.
A secure optical storage based on a configuration of a joint transform correlator by use of a photorefractive material is presented. A key code designed through the use of an optimized algorithm so that its Fourier transform has a uniform amplitude distribution and a uniformly random phase distribution is introduced. Original two-dimensional data and the key code are placed side-by-side at the input plane. Both of them are stored in a photorefractive material as a joint power spectrum. The retrieval of the original data can be achieved with the same key code. We can record multiple two-dimensional data in the same crystal by angular multiplexing and/or key code multiplexing. 相似文献
34.
L-Canavanine is a nonprotein amino acid contained in jack bean [Canavalia ensiformis (L.) DC] and shows a plant inhibitory effect. The inhibitory effect was determined by an immersion test and a microdrop test that employed rice seedlings. L-Canavanine inhibited elongation of the second leaf sheath of rice seedlings more than other natural bioactive substances, such as salicylic acid and cinnamic acid. The modified microdrop test revealed that the mode of action of L-canavanine had no relation to gibberellin synthesis. In the microdrop test, the inhibitory effect of L-canavanine was decreased by simultaneous addition of L-arginine, an analog of L-canavanine. Free amino acid analysis of rice shoots clearly showed that L-canavanine induced an unusual accumulation of L-arginine. However, accumulation of L-arginine did not cause the inhibitory effect on plant growth. These results suggest that the mechanism of inhibition of L-canavanine is closely related to the inhibition of arginine metabolism. 相似文献
35.
In canonical correlation analysis (CCA), it is important to estimate the number of nonzero canonical correlations in the population. One way to estimate the number is to consider the dimensionality testing problem. In CCA for continuous variables, some test statistics for the problem have been derived under the normality assumption. However, there are only a few papers on test statistics in CCA for categorical variables.
In this article, a test statistic in CCA for categorical variables is suggested. The test statistic is derived from the rational used for continuous variables. Some properties of the test statistic are examined through mathematical investigations and numerical simulations.
相似文献36.
Naoki Uchida Yoshie Maitani Yoshiharu Machida Masayuki Nakagaki Tsuneji Nagai 《Drug development and industrial pharmacy》1991,17(12):1625-1634
The nasal drug absorption and the effect of absorption promoters have been studied in rabbits. Nasal mucosa excised from rabbits was mounted as a flat sheet in an in vitro chamber. The result indicates that the change in the porosity of the membrane by pretreatment with bile salts increased the permeability coefficient of sodium chloride in the nasal membrane. The permeabilities of dextran derivatives were enhanced by pretreatment with sodium glycocholate (GC). The permeability coefficient (P) of fluorescein isothiocyanate diethylaminoethyl dextran 相似文献
37.
M Iwabuchi S Haruta A Taguchi Y Ichikawa T Genda S Katai T Imaoka Y Shimizu M Owa 《Canadian Metallurgical Quarterly》1997,30(6):1437-1444
OBJECTIVES: This study sought to evaluate the intravascular structure as depicted by intravascular ultrasound after successful primary angioplasty (i.e., without thrombolytic therapy) for acute myocardial infarction and to investigate the related predictors of acute coronary occlusion. BACKGROUND: The usefulness of primary angioplasty for acute myocardial infarction is still limited by early reocclusion. There are few data regarding the intravascular ultrasound findings after primary angioplasty. METHODS: Intravascular ultrasound was performed in 27 patients after successful primary angioplasty. Repeat coronary angiography was performed 15 min later, on the following day and 1 month after angioplasty. RESULTS: Abrupt occlusion occurred in 8 of 27 patients. Angiographic variables in patients with versus those without abrupt occlusion were not significantly different. Intravascular ultrasound disclosed a significantly smaller lumen area ([mean +/- SD] 2.49 +/- 0.72 vs. 5.06 +/- 1.52 mm2, p < 0.001) and a significantly greater percent plaque area (80.5 +/- 9.1% vs. 63.7 +/- 7.8%, p < 0.001) in patients with abrupt occlusion. There was no significant difference in external elastic membrane cross-sectional area. We classified the ultrasound appearance of the intravascular structure as smooth, irregular or filled. Abrupt occlusion occurred in none of 6 patients with a smooth intravascular structure, 24% of 17 patients with an irregular structure and in all 4 with a filled structure (p < 0.05). In the latter group, the lumen was filled with bright speckled or low echogenic material, although angiography revealed excellent coronary dilation in all these arteries. CONCLUSIONS: Intravascular ultrasound revealed a narrow lumen in coronary arteries showing abrupt occlusion after successful primary angioplasty, even though angiography disclosed successful dilation. Arteries with a lumen filled with bright speckled or low echogenic material frequently develop abrupt occlusion. 相似文献
38.
Yoshiharu Hatakeyama Mitsuo Umetsu Masahiro Minami Satoshi Ohara Seiichi Takami Tadafumi Adschiri 《Journal of Materials Science》2008,43(7):2426-2430
The DNA, which forms a double helical conformation by the highly selective base-pairing rule with the width of 2 nm, is one
of the polymers utilized as a template for nanoparticle assembly. Then, holiday junction structure, where two different DNA
double strands intersect and replace each complement strand, is an important artificial motif for forming two-dimensional
mesh-like DNA morphology. In this study, the two-dimensional sheet with the mesh-like conformation is formed and the growth
of the DNA morphology is controlled by changing the temperature in the formation process. The influence of the cooling procedure
on the formation process of the two-dimensional DNA sheet is observed by atomic force microscope, and the formation of double
strands in the process is traced by absorption spectra. The spectroscopic results demonstrate that the two-dimensional DNA
sheet is strongly dependent on the correlation between the applied cooling process and the melting temperature of double helical
conformation, and that the growth of the two-dimensional DNA sheet can be manipulated by the cooling procedure. Further, we
will show the size control of the DNA sheet by mixing the designed DNA which inhibits the growth of the DNA sheet. 相似文献
39.
The possibility of severe recriticality could be excluded if the molten core materials are discharged from reactor core in the early stage of core disruptive accident (CDA). Based on this idea, several design measures for future commercial liquid metal-cooled fast breeder reactors (LMFBRs) have been proposed to enhance the molten fuel discharge from core in order to prevent formation of the core-wide molten pool with high mobility. One promising concept in these design candidates is modified-FAIDUS (Fuel subassembly with Inner DUct Structure). The event progression in unprotected loss of flow (ULOF) accident in a sodium-cooled large scale FBR with modified-FAIDUS was analyzed to assess the effectual performance of modified-FAIDUS in preventing severe recriticality using the SAS4A and SIMMER-III codes. Two parametric cases were performed covering the uncertainty of duct wall failure mechanism, one with stable fuel crust and another with unstable crust condition. The calculation showed that the final amount of discharged fuel from core in both cases was more than 20% of initial core inventory. The degraded core after fuel discharge is composed of the mixture of solidified fuel, swollen fuel chunks and molten steel, of which low mobility prevents massive fuel motion. The reactor power lowered to decay heat level and the reactivity lowered around −20 $, thus, the possibility of severe recriticality was eliminated. 相似文献
40.
Kubota K Kasuga F Iwasaki E Inagaki S Sakurai Y Komatsu M Toyofuku H Angulo FJ Scallan E Morikawa K 《Journal of food protection》2011,74(10):1592-1598
Most cases of acute gastroenteritis and foodborne disease are not ascertained by public health surveillance because the ill person does not always seek medical care and submit a stool sample for testing, and the laboratory does not always test for or identify the causative organism. We estimated the total burden of acute gastroenteritis in Miyagi Prefecture, Japan, using data from two 2-week cross-sectional, population-based telephone surveys conducted in 2006 and 2007. To estimate the number of acute gastroenteritis illnesses caused by Campylobacter, Salmonella, and Vibrio parahaemolyticus in Miyagi Prefecture, we determined the number of cases for each pathogen from active laboratory-based surveillance during 2005 to 2006 and adjusted for seeking of medical care and submission of stool specimens by using data from the population-based telephone surveys. Monte Carlo simulation was used to incorporate uncertainty. The prevalence of acute gastroenteritis in the preceding 4 weeks was 3.3% (70 of 2,126) and 3.5% (74 of 2,121) in the winter and summer months, yielding an estimated 44,200 episodes of acute gastroenteritis each year in this region. Among people with acute gastroenteritis, the physician consultation rate was 32.0%, and 10.9% of persons who sought care submitted a stool sample. The estimated numbers of Campylobacter-, Salmonella-, and V. parahaemolyticus -associated episodes of acute gastroenteritis were 1,512, 209, and 100 per 100,000 population per year, respectively, in this region. These estimates are significantly higher than the number of reported cases in surveillance in this region. Cases ascertained from active surveillance were also underrepresented in the present passive surveillance, suggesting that complementary surveillance systems, such as laboratory-based active surveillance in sentinel sites, are needed to monitor food safety in Japan. 相似文献