On the Performance of FFT/DWT/DCT-based OFDM Systems with Chaotic Interleaving and Channel Estimation Algorithms

The efficiency of data transmission over fading channels in orthogonal frequency division multiplexing (OFDM) systems depends on the employed interleaving method. In this study, we propose an improved chaotic interleaving scheme which aims to improve the performance of OFDM system under fading channel. In the proposed scheme, the binary data is interleaved with chaotic Baker map prior to the modulation process. In the sequel, significant degree of encryption is being added during data transmission. The performance of the proposed approach is tested on the conventional fast Fourier transform OFDM, discrete wavelet transform OFDM, and discrete cosine transform OFDM with and without chaotic interleaving. Furthermore, an expectation–maximization (EM) algorithm is proposed for improving channel impulse response (CIR) estimation based on a maximum likelihood principle. The proposed scheme makes use of EM algorithm to update the channel estimates until convergence is reached. The simulation results show the efficiency of the proposed algorithms under Rayleigh fading environments where the symbol error rate essentially coincides with that of the perfect channel case after the fifth EM iteration.     

Short communication: effects of supplementation with pomegranate seed pulp on concentrations of conjugated linoleic acid and punicic acid in goat milk

The effects of feeding pomegranate seed pulp (PSP) on milk yield, milk composition, fatty acid profiles of milk fat, and blood metabolites were examined in this study. During a pretrial period, 27 multiparous southern Khorasan (Iran) cross-bred goats were fed a similar diet and dry matter intake, milk yield, and milk composition were recorded. After adaptation and based on pretrial records, the goats were randomly assigned to 1 of 3 experimental diets and were housed in individual stalls. Experimental diets included 0, 6, or 12% of PSP (dry matter basis) and were fed as total mixed rations ad libitum for a 45-d period. Diets were formulated to be isonitrogenous and isocaloric. Supplementation of PSP did not affect dry matter intake or average daily gain of goats. Milk yield was not affected by inclusion of PSP in the diet. Milk fat concentration of goats fed diets with 6 and 12% PSP increased, but milk fat yield, milk protein concentration, and milk solids-not-fat concentration of goats were not affected by diets. Feeding PSP did not affect blood glucose, cholesterol, urea N, triglyceride, or lipoproteins. Feeding goats a diet containing 12% PSP modified the milk fatty acid profile, including conjugated linoleic, punicic, and vaccenic acids.     

A Comparison Study Between Pre-Equalization Schemes for Single and Multi Carrier Modulation Systems

In this paper, frequency domain pre-equalization (Pre-FDE) is developed for broadband cyclic prefix-code division multiple access (CP-CDMA) as a single carrier transmission scheme, and for multi carrier-CDMA (MC-CDMA) and orthogonal frequency division multiplexing (OFDM) as multi carrier transmission schemes. A comparison study is held between these schemes and the traditional equalization schemes. Experimental results show that pre-equalization improves significantly the performance of the single and multi carrier communication systems with a very low complexity at the receiver. The comparative study between MIMO pre-equalization for single carrier systems and for multi carrier systems shows that MIMO pre-equalization for single carrier systems outperforms that for multi carrier systems in terms of bit error rate (BER) performance since single carrier transmission has more frequency diversity than multi carrier transmission in the uncoded case.     

In Vitro Rescue of the Bile Acid Transport Function of ABCB11 Variants by CFTR Potentiators

ABCB11 is responsible for biliary bile acid secretion at the canalicular membrane of hepatocytes. Variations in the ABCB11 gene cause a spectrum of rare liver diseases. The most severe form is progressive familial intrahepatic cholestasis type 2 (PFIC2). Current medical treatments have limited efficacy. Here, we report the in vitro study of Abcb11 missense variants identified in PFIC2 patients and their functional rescue using cystic fibrosis transmembrane conductance regulator potentiators. Three ABCB11 disease-causing variations identified in PFIC2 patients (i.e., A257V, T463I and G562D) were reproduced in a plasmid encoding an Abcb11-green fluorescent protein. After transfection, the expression and localization of the variants were studied in HepG2 cells. Taurocholate transport activity and the effect of potentiators were studied in Madin–Darby canine kidney (MDCK) clones coexpressing Abcb11 and the sodium taurocholate cotransporting polypeptide (Ntcp/Slc10A1). As predicted using three-dimensional structure analysis, the three variants were expressed at the canalicular membrane but showed a defective function. Ivacaftor, GLP1837, SBC040 and SBC219 potentiators increased the bile acid transport of A257V and T463I and to a lesser extent, of G562D Abcb11 missense variants. In addition, a synergic effect was observed when ivacaftor was combined with SBC040 or SBC219. Such potentiators could represent new pharmacological approaches for improving the condition of patients with ABCB11 deficiency due to missense variations affecting the function of the transporter.     

Detection of Abnormal Activities from Various Signals Based on Statistical Analysis

We perceive big data with massive datasets of complex and variegated structures in the modern era. Such attributes formulate hindrances while analyzing and storing the data to generate apt aftermaths. Privacy and security are the colossal perturb in the domain space of extensive data analysis. In this paper, our foremost priority is the computing technologies that focus on big data, IoT (Internet of Things), Cloud Computing, Blockchain, and fog computing. Among these, Cloud Computing follows the role of providing on-demand services to their customers by optimizing the cost factor. AWS, Azure, Google Cloud are the major cloud providers today. Fog computing offers new insights into the extension of cloud computing systems by procuring services to the edges of the network. In collaboration with multiple technologies, the Internet of Things takes this into effect, which solves the labyrinth of dealing with advanced services considering its significance in varied application domains. The Blockchain is a dataset that entertains many applications ranging from the fields of crypto-currency to smart contracts. The prospect of this research paper is to present the critical analysis and review it under the umbrella of existing extensive data systems. In this paper, we attend to critics' reviews and address the existing threats to the security of extensive data systems. Moreover, we scrutinize the security attacks on computing systems based upon Cloud, Blockchain, IoT, and fog. This paper lucidly illustrates the different threat behaviour and their impacts on complementary computational technologies. The authors have mooted a precise analysis of cloud-based technologies and discussed their defense mechanism and the security issues of mobile healthcare.

     

Iron oxide/gold nanoparticles‐decorated reduced graphene oxide nanohybrid as the thermo‐radiotherapy agent

The main focus of the current study is the fabrication of a multifunctional nanohybrid based on graphene oxide (GO)/iron oxide/gold nanoparticles (NPs) as the combinatorial cancer treatment agent. Gold and iron oxide NPs formed on the GONPs via the in situ synthesis approach. The characterisations showed that gold and iron oxide NPs formed onto the GO. Cell toxicity assessment revealed that the fabricated nanohybrid exhibited negligible toxicity against MCF‐7 cells in low doses (<50 ppm). Temperature measurement showed a time and dose‐dependent heat elevation under the interaction of the nanohybrid with the radio frequency (RF) wave. The highest temperature was recorded using 200 ppm concentration nanohybrid during 40 min exposure. The combinatorial treatments demonstrated that the maximum cell death (average of 53%) was induced with the combination of the nanohybrid with RF waves and radiotherapy (RT). The mechanistic study using the flow cytometry technique illustrated that early apoptosis was the main underlying cell death. Moreover, the dose enhancement factor of 1.63 and 2.63 were obtained from RT and RF, respectively. To sum up, the authors’ findings indicated that the prepared nanohybrid could be considered as multifunctional and combinatorial cancer therapy agents.Inspec keywords: radiation therapy, toxicology, gold, biomedical materials, nanofabrication, nanoparticles, iron compounds, cancer, nanomedicine, cellular biophysics, tumours, graphene compounds, biothermicsOther keywords: graphene oxide nanohybrid, combinatorial cancer treatment agent, cell toxicity assessment, MCF‐7 cells, dose‐dependent heat elevation, multifunctional cancer therapy agents, thermoradiotherapy agent, graphene oxide‐iron oxide‐gold nanoparticles, temperature measurement, radiofrequency wave, flow cytometry, time 40.0 min, CO‐FeO‐Au     

Leakage-resilient security architecture for mobile IPv6 in wireless overlay networks

The coupling of mobility and quality-of-service with security is a challenge that should be addressed in future wireless overlay systems. The mobility of a node can disrupt or even intermittently disconnect an ongoing real-time session because a secure handover must be performed to ensure continuous connectivity. The duration of the such interruptions is called disruption time or handover delay and can heavily affect the user satisfaction. The handover procedure needs to protect its integrity and confidentiality-otherwise, the packets may be rerouted to a malicious node and the legitimate handover may not be performed. The security procedure to ensure this should not lengthen significantly the handover delay to provide good quality real-time services. In this paper, we focus on the network-layer mobility, specifically, on Mobile Internet protocol version 6 (MIPv6) since it is the natural candidate for providing such mobility in future systems. To solve the problem of on-path attackers and prevent leakage of secrets, we propose a security architecture for MIPv6 based on leakage resilient-authenticated key establishment (LR-AKE) protocol and its cooperation with public key infrastructure. The proposed architecture prevents against on-path attackers which was not addressed in the specifications of MIPv6, and also provides robustness against leakage of secret values. Using analytical models, we evaluate MIPv6 handover delay for real-time services. We identify the crucial factors affecting the handover delay among transmission delays of MIPv6, security and LR-AKE messages, queueing delays and en/decryption delays.     

Optimized release of dexamethasone and gentamicin from a soluble ocular insert for the treatment of external ophthalmic infections

The aziridinium ion of ethylcholine (AF64A), a cholinergic neurotoxin, was injected into the right striatum of a rat. The unilateral injection of 10 nmol AF64A reduced the activity of choline acetyltransferase (CAT) and the tissue content of acetylcholine (ACh) in the striatum. The striatal contents of dopamine (DA), norepinephrine (NE), 5-hydroxyindoleacetic acid (5-HIAA) and gamma-aminobutyric acid (GABA) were unchanged. These results suggest that the cholinospecificity in the striatal lesion was induced by the 10 nmol dose of AF64A. The number of N-methyl-D-aspartic acid (NMDA) receptors in the striatum treated with 10 nmol AF64A was determined by a specific binding assay using [3H](+/-)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid ([3H]CPP), a selective ligand for NMDA receptors. The number of the NMDA receptors decreased significantly in the injected area. On the other hand, in a microdialysis using normal rats, the perfusion of 50 microM NMDA into the striatum increased ACh release. The perfusion of 100 microM MK801 which is the specific and non-competitive NMDA receptor antagonist, decreased the basal levels of ACh release and blocked NMDA-elicited ACh release. Taken together, the present results strongly suggest that a population of NMDA receptors exists on cholinergic interneurons within the striatum, and it directly regulates ACh release.     

Amine plant simulation by mass transfer and kinetic approach

A computer program has been developed for the simulation of gas-liquid absorption columns. The calculations are based on known assumptions and methods – the two-film theory. Mass and energy balances together with chemical reactions are carried out for each tray of the column. The results obtained from the simulation procedure are compared with those measured at industrial plants. For the items “rich solution temperature” and “calculated number of trays” the agreement of calculated and measured results are satisfactory. However, for the CO₂ and H₂S content of the streams only few comparisons could be made due to the fact that no measured values are available.