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11.
T. Iwashita K. Yosui M. Mori E. Kobayashi S. Abe 《Computing and Visualization in Science》2008,11(3):123-128
A multi-grid method is one of the most powerful linear solvers for finite element electromagnetic field analysis. However,
as the discretized model has recently been enlarged, a solution process for a linear system arising on the coarsest level
tends to be problematic in a complete multi-grid solution process. Whereas a linear system on the coarsest level is generally
solved by a direct solver, we solve it here by means of an iterative solver to reduce the memory requirements. Since a conventional
preconditioning technique is not effective for such a linear system, we introduce preconditioning techniques based on Arnold,
Falk, and Winther’s and on Hiptmair’s smoothers. Numerical tests show that the newly installed preconditioning technique greatly
improves the convergence rate. 相似文献
12.
Progress of psychotherapy and of related behaviour sciences makes evident the importance of a better understanding of human relations. But psychoanalysis finds it hard to describe interpersonal processes without transference. In order to remain within the conceptional frame of metapsychology it has to see interaction between individuals as the oral, aggressive or sexual cathexis of an object or as satisfaction or denial of the subject by the object. The structure of the "ego", which--in analogy to medical thinking--is conceived as an organ with its functions, is considered to have no interpersonal activities. The "ego" of the classic psychoanalytic theory is chiefly occupied with itself. It has to care for its egoistical interests and to guarantee its self-preservation. As an auxiliary and meanwhile popular concept the "self" has been introduced to describe object-relations. This concept is not sharply defined. Due to its metapsychological implications it produces additional theoretical difficulties. Linguistic studies show that every inventory of words implies a certain insight into reality. For this reason the metapsychological machine-like concept of psychic structures does not permit new ideas about interpersonal relations. If we leave metapsychology and base on colloquial speech we see that the experience of "I" is much more related to persons than the rather autistic concept of the "ego" shows. Further we learn that self-preservation cannot be an egoistical interest; it depends on the attachment to others. All feelings of self-esteem depend much more on interpersonal relations than on "narcissistic regulations". From these experiences three conclusions are derived: a) One of the main qualities of the ego is the relatedness to persons. b) The concept of narcissistic regulation as a successor of primary narcissism is no longer useful. Narcissistic traits develop as the secundary compensations if the individual failed to build up satisfactory interpersonal relations. c) The revision of (a) ego-psychology and (b) theory of narcissism asks for modifications of the therapeutic technique, where now the interest is especially concentrated on interpersonal problems instead on the pathology of the ego. 相似文献
13.
The effects of impurity doping in CrO/sub 2/ have been calculated based on the Cr/sub 9/O/sub 40/ cluster using the method of DV-X /spl alpha/ molecular orbital calculation. Elements (Mo, W) belonging to the same family as Cr and the ones (Zr, Ru, Sn) whose dioxides have the same crystalline structure as the rutile were selected for impurity doping. The calculated results show the large enhancements of the magnetic moment and the Curie temperature by the doping of Zr and Ru, respectively. 相似文献
14.
Minami Yamauchi Toshihiro Sato Ayana Otake Masaki Kumondai Yu Sato Masafumi Kikuchi Masamitsu Maekawa Hiroaki Yamaguchi Takaaki Abe Nariyasu Mano 《International journal of molecular sciences》2022,23(15)
Patients with liver diseases not only experience the adverse effects of liver-metabolized drugs, but also the unexpected adverse effects of renally excreted drugs. Bile acids alter the expression of renal drug transporters, however, the direct effects of bile acids on drug transport remain unknown. Renal drug transporter organic anion-transporting polypeptide 4C1 (OATP4C1) was reported to be inhibited by chenodeoxycholic acid. Therefore, we predicted that the inhibition of OATP4C1-mediated transport by bile acids might be a potential mechanism for the altered pharmacokinetics of renally excreted drugs. We screened 45 types of bile acids and calculated the IC50, Ki values, and bile acid–drug interaction (BDI) indices of bile acids whose inhibitory effect on OATP4C1 was >50%. From the screening results, lithocholic acid (LCA), glycine-conjugated lithocholic acid (GLCA), and taurine-conjugated lithocholic acid (TLCA) were newly identified as inhibitors of OATP4C1. Since the BDI index of LCA was 0.278, LCA is likely to inhibit OATP4C1-mediated transport in clinical settings. Our findings suggest that dose adjustment of renally excreted drugs may be required in patients with renal failure as well as in patients with hepatic failure. We believe that our findings provide essential information for drug development and safe drug treatment in clinics. 相似文献
15.
Yosuke Inomata Jae-Won Oh Kohei Taniguchi Nobuhiko Sugito Nao Kawaguchi Fumitoshi Hirokawa Sang-Woong Lee Yukihiro Akao Shinji Takai Kwang-Pyo Kim Kazuhisa Uchiyama 《International journal of molecular sciences》2022,23(9)
Non-alcoholic steatohepatitis (NASH) has pathological characteristics similar to those of alcoholic hepatitis, despite the absence of a drinking history. The greatest threat associated with NASH is its progression to cirrhosis and hepatocellular carcinoma. The pathophysiology of NASH is not fully understood to date. In this study, we investigated the pathophysiology of NASH from the perspective of glycolysis and the Warburg effect, with a particular focus on microRNA regulation in liver-specific macrophages, also known as Kupffer cells. We established NASH rat and mouse models and evaluated various parameters including the liver-to-body weight ratio, blood indexes, and histopathology. A quantitative phosphoproteomic analysis of the NASH rat model livers revealed the activation of glycolysis. Western blotting and immunohistochemistry results indicated that the expression of pyruvate kinase muscle 2 (PKM2), a rate-limiting enzyme of glycolysis, was upregulated in the liver tissues of both NASH models. Moreover, increases in PKM2 and p-PKM2 were observed in the early phase of NASH. These observations were partially induced by the downregulation of microRNA122-5p (miR-122-5p) and occurred particularly in the Kupffer cells. Our results suggest that the activation of glycolysis in Kupffer cells during NASH was partially induced by the upregulation of PKM2 via miR-122-5p suppression. 相似文献
16.
Seiichiro Katagiri SungGi Chi Yosuke Minami Kentaro Fukushima Hirohiko Shibayama Naoko Hosono Takahiro Yamauchi Takanobu Morishita Takeshi Kondo Masamitsu Yanada Kazuhito Yamamoto Junya Kuroda Kensuke Usuki Daigo Akahane Akihiko Gotoh 《International journal of molecular sciences》2022,23(9)
KIT is a type-III receptor tyrosine kinase that contributes to cell signaling in various cells. Since KIT is activated by overexpression or mutation and plays an important role in the development of some cancers, such as gastrointestinal stromal tumors and mast cell disease, molecular therapies targeting KIT mutations are being developed. In acute myeloid leukemia (AML), genome profiling via next-generation sequencing has shown that several genes that are mutated in patients with AML impact patients’ prognosis. Moreover, it was suggested that precision-medicine-based treatment using genomic data will improve treatment outcomes for AML patients. This paper presents (1) previous studies regarding the role of KIT mutations in AML, (2) the data in AML with KIT mutations from the HM-SCREEN-Japan-01 study, a genome profiling study for patients newly diagnosed with AML who are unsuitable for the standard first-line treatment (unfit) or have relapsed/refractory AML, and (3) new therapies targeting KIT mutations, such as tyrosine kinase inhibitors and heat shock protein 90 inhibitors. In this era when genome profiling via next-generation sequencing is becoming more common, KIT mutations are attractive novel molecular targets in AML. 相似文献
17.
Yasuyoshi Kaneko Shinya Matsushita Yasufumi Oikawa Shigeru Abe 《Electrical Engineering in Japan》2010,172(2):47-54
The equivalent circuit, the efficiency, and the important characteristics of moving pick‐up type contactless power transfer systems are described. If the primary series capacitor and the secondary parallel capacitors are chosen correctly and the winding resistances are ignored, the equivalent circuit of the transformer with these capacitors becomes the same as an ideal transformer at the resonant frequency. This simple approximation helps to understand the phenomena occurring with load changes. Because the circuit analysis becomes simple, the approximate value of the power transfer efficiency can be derived. This paper describes the determination of the capacitor values, the derivation of the equivalent circuit and the efficiency, and test results. © 2010 Wiley Periodicals, Inc. Electr Eng Jpn, 172(2): 47–54, 2010; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.20970 相似文献
18.
A novel super-multi-fibre planar lightwave circuit (PLC) connector, designed to connect tens of optical fibres and a PLC for super-multichannel PLC-based optical modules with a receptacle interface, is proposed. This connector employs an angled connection instead of a PC connection. A 0.127 mm pitch 32-fibre connector is also demonstrated, which exhibits low connection and high return losses. 相似文献
19.
A new space-time turbo equalization algorithm is derived for frequency-selective multiple-input-multiple-output (MIMO) channels with unknown interference. The algorithm is an extension of our proposed MIMO equalization algorithm , which performs joint channel estimation, multiple users' signal detection, and decoding, all in an iterative manner. This paper's proposed algorithm uses estimates of the correlation matrix of composite unknown interference-plus-noise components to suppress the unknown interference while effectively separating multiple users' signals to be detected (referred to as "known user" later). The correlation matrix of the composite unknown interference-plus-noise components can be estimated by time averaging the instantaneous empirical correlation matrix over the training period. Since the iterative channel estimation yields better channel estimates as more iterations are performed, thereby the estimate of the correlation matrix of the unknown interference-plus-noise components also becomes more accurate. This results in better signal detection performances, even in the presence of unknown interferers. A series of computer simulations show that this paper's proposed algorithm can properly separate known users' signals while suppressing unknown interference. 相似文献
20.
Numerical prediction of fraction of eutectic phase in Sn−Ag−Cu soldring using the phase-field method
Machiko Ode Minoru Ueshima Taichi Abe Hideyuki Murakami Hidehiro Onodera 《Journal of Electronic Materials》2006,35(11):1969-1974
A combination of macroscale solidification simulation and phase-field calculation is employed to predict the volume fraction
of the eutectic phase in Sn-4.0 mass% Ag-XCu solder alloys (X=0.5–1.1 mass%). The solidification simulation incorporates the
cooling rate in the phase-field simulation. We assume the residual liquid solidifies as eutectic phase when the driving force
for the nucleation of Cu6Sn5 amounts to a critical value, which is determined based on the experimental data. Though the calculation results depend on
the experimental data, the obtained fractions are about 40% for 0.5 mass% Cu and more than 90% for 1.1 mass% Cu alloy, which
shows good agreement with the experimental data. 相似文献