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31.
A Younes J Romaguera O Mesina F Hagemeister AH Sarris MA Rodriguez P McLaughlin HA Preti C Bachier F Cabanillas 《Canadian Metallurgical Quarterly》1998,103(3):678-683
Based on the single-agent activity of both paclitaxel and cyclophosphamide in the treatment of non-Hodgkin's lymphoma (NHL), we conducted a phase II study to evaluate the efficacy of the combination of the two drugs in patients with refractory and relapsed aggressive NHL. All patients received 900 mg/m2 bolus of cyclophosphamide intravenously daily for 3 consecutive days with a concurrent infusion of 150 mg/m2 of paclitaxel over 72 h (50 mg/m2/d). 24 h after the completion of chemotherapy, patients received subcutaneous injections of 5 microg/kg of granulocyte-colony stimulating factor (G-CSF) daily until white cell count recovery. Treatment was repeated every 3 weeks. Patients who had at least a partial response (PR) after two courses continued to receive a maximum of four courses. Patients with responding disease were allowed to undergo high-dose chemotherapy followed by stem-cell/bone marrow transplantation if they were eligible. Of the 77 patients who were eligible for the study, 74 (96%) were evaluable for toxicity and treatment response. The overall response rate was 45% (95% CI 33-57%). Patients who received treatment after their disease relapsed from a complete response (CR) had an 81% response rate (38% CRs), whereas those with primary refractory disease had a 22% response rate. Toxicities of > grade 2 included alopecia (100%) and stomatitis (25%). Neutropenic fever of grade > 2 occurred after 18% of the courses, and platelet count of < or = 20 x 10(9)/l developed after 20% of the courses. Thus, the combination of paclitaxel plus high-dose cyclophosphamide is an effective new regimen in the treatment of refractory and relapsed NHL. 相似文献
32.
Ch. P. El Soueidy A. Younes P. Ackerer 《International journal for numerical methods in engineering》2009,79(9):1068-1093
Explicit schemes are known to provide less numerical diffusion in solving the advection–diffusion equation, especially for advection‐dominated problems. Traditional explicit schemes use fixed time steps restricted by the global CFL condition in order to guarantee stability. This is known to slow down the computation especially for heterogeneous domains and/or unstructured meshes. To avoid this problem, local time stepping procedures where the time step is allowed to vary spatially in order to satisfy a local CFL condition have been developed. In this paper, a local time stepping approach is used with a numerical model based on discontinuous Galerkin/mixed finite element methods to solve the advection–diffusion equation. The developments are detailed for general unstructured triangular meshes. Numerical experiments are performed to show the efficiency of the numerical model for the simulation of (i) the transport of a solute on highly unstructured meshes and (ii) density‐driven flow, where the velocity field changes at each time step. The model gives stable results with significant reduction of the computational cost especially for the non‐linear problem. Moreover, numerical diffusion is also reduced for highly advective problems. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
33.
Dilmi Nacer Bacha Nacer-Eddine Younes Abderrahmane 《Powder Metallurgy and Metal Ceramics》2020,59(1-2):35-45
Powder Metallurgy and Metal Ceramics - This work aims to study the effect of mechanical milling of Fe, ZnO, and Ni elemental powders and thermal spraying processes on chemical composition,... 相似文献
34.
35.
M Younes RW Brown M Stephenson M Gondo PT Cagle 《Canadian Metallurgical Quarterly》1997,80(6):1046-1051
We report the electrophysiologic findings of myoclonus in a patient with Huntington's disease (HD). This patient was studied postoperatively after a bilateral fetal cell transplant in his striatum. Incomplete transient improvement was seen in the myoclonus, followed by gradual deterioration. The myoclonus itself had a cortical correlate and was associated with an enlarged somatosensory evoked potential (SEP), consistent with the presence of cortical reflex myoclonus. An enlarged SEP has not been previously reported in myoclonus associated with HD. The postulated mechanisms for myoclonus, when it occurs in HD, have differed in the literature. The reason for the transient improvement of the myoclonus following transplantation is unclear, but this case raises the possibility that basal ganglia circuits may modulate cortical myoclonic activity. 相似文献
36.
GG Hillman E Younes D Visscher F Hamzavi S Kim JS Lam EJ Montecillo E Ali JE Pontes RK Puri GP Haas 《Canadian Metallurgical Quarterly》1997,3(10):1799-1806
We have previously demonstrated that IFN-gamma causes cell growth inhibition and up-regulation of MHC antigens in human renal cell carcinoma cell lines. In this study, we have investigated the therapeutic potential of IFN-gamma for the treatment of 5-day established pulmonary metastases induced by i.v. injection of Renca cells, a murine renal adenocarcinoma. We found that systemic injections of IFN-gamma significantly reduced the number of lung metastases in a dose-dependent manner and increased mouse survival. Histological evaluation of IFN-gamma-treated lungs showed residual small tumor nodules containing extensive necrosis and mononuclear infiltrates. Immunohistochemistry studies on lung sections showed macrophage infiltration into tumor nodules, and in vivo depletion of macrophages partially inhibited IFN-gamma antitumor effect, suggesting a role for the macrophages in tumor destruction. Lymphocyte depletion of either natural killer (NK) cells or CD4+ or CD8+ T-cell subsets or both T-cell subsets did not affect the IFN-gamma effect, whereas depletion of both NK and T cells decreased the antitumor activity of IFN-gamma. These data indicate that neither T cells nor NK cells are essential for this activity but that either lymphocyte population can contribute to the IFN-gamma effect. An optimal dose of IFN-gamma inhibited by 60% the growth of Renca cells treated for 3 days in vitro, but this effect was transient and less pronounced in a long-term colony assay, suggesting that IFN-gamma direct growth inhibition may play a role but may not be sufficient to mediate its antitumor effect in vivo. In vitro, IFN-gamma caused up-regulation of class I MHC antigens and induction of class II antigen expression in Renca cells, an effect that may enhance Renca immunogenicity but may be relevant only when a T-cell response is elicited. A sequential administration of IFN-gamma followed by interleukin 4 was therapeutically better than IFN-gamma alone for the treatment of advanced pulmonary metastases, probably due to different antitumor mechanisms induced by these two cytokines. 相似文献
37.
Several Software Reliability Growth Models (SRGMs) have been developed in the literature assuming the debugging process to be perfect and thus implying that there is one-to-one correspondence between the number of failures observed and errors removed. However, in reality it is possible that the error which is supposed to have been removed may cause a failure again. It may be due to the spawning of a new error because of imperfect debugging. If such a phenomenon exists then the Software Reliability Growth is S-shaped. In this paper, we develop a model which can describe imperfect debugging process and has the inbuilt flexibility of capturing a wide class of growth curves. Earlier attempts of modelling such a process were able to capture only a particular curve. In other words, if a failure observation phenomenon is exponential then the error removal is again modelled by an exponential growth curve. Applicability of the model has been shown on several data sets obtained from different software development projects. 相似文献
38.
Neural networks in forecasting electrical energy consumption: univariate and multivariate approaches
This paper presents an artificial neural network (ANN) approach to electric energy consumption (EEC) forecasting in Lebanon. In order to provide the forecasted energy consumption, the ANN interpolates among the EEC and its determinants in a training data set. In this study, four ANN models are presented and implemented on real EEC data. The first model is a univariate model based on past consumption values. The second model is a multivariate model based on EEC time series and a weather‐dependent variable, namely, degree days (DD). The third model is also a multivariate model based on EEC and a gross domestic product (GDP) proxy, namely, total imports (TI). Finally, the fourth model combines EEC, DD and TI. Forecasting performance measures such as mean square errors (MSE), mean absolute deviations (MAD), mean percentage square errors (MPSE) and mean absolute percentage errors (MAPE) are presented for all models. Copyright © 2002 John Wiley & Sons, Ltd. 相似文献
39.
40.
Saoud A. M. Metwally Mohamed S. K. Youssef Mansour I. Younes 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》1980,30(1):513-519
1-Hydroxy and/or 1-aminoanthraquinone was allowed to react with formaldehyde in an alkaline medium to give 1-hydroxy or 1-amino-2-hydroxymethyl-9,10-dihydroxy-anthracenes, which gave on air oxidation, hydroxymethylanthraquinone derivatives (I). Interaction of 1-amino-2-hydroxymethylanthraquinone or its 4-bromo derivative with carbonyl compounds in the presence of an acid catalyst gave (1,3)oxazine derivatives (II). The methylene group in position-2 of the (1,3)oxazine ring was found to be highly reactive and reacted with carbonyl compounds to form the corresponding arylidenes (III). Selective oxidation of dimethyl oxazine derivatives with SeO2 gave the corresponding dialdehyde (IV), which interacted with aromatic amines to give the corresponding Schiff bases (V). The bromine atom in the 6-position of II was easily replaced by aromatic amines to give blue disperse dyes (VI). 相似文献