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排序方式: 共有977条查询结果,搜索用时 109 毫秒
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Sylvain Lamoine Mlissa Cumenal David A. Barriere Vanessa Pereira Mathilde Fereyrolles Laëtitia Prival Julie Barbier Ludivine Boudieu Emilie Brasset Benjamin Bertin Yoan Renaud Elisabeth Miot-Noirault Marie-Ange Civiale David Balayssac Youssef Aissouni Alain Eschalier Jrme Busserolles 《International journal of molecular sciences》2022,23(1)
44.
Gracia Fahed Laurence Aoun Morgan Bou Zerdan Sabine Allam Maroun Bou Zerdan Youssef Bouferraa Hazem I. Assi 《International journal of molecular sciences》2022,23(2)
Metabolic syndrome (MetS) forms a cluster of metabolic dysregulations including insulin resistance, atherogenic dyslipidemia, central obesity, and hypertension. The pathogenesis of MetS encompasses multiple genetic and acquired entities that fall under the umbrella of insulin resistance and chronic low-grade inflammation. If left untreated, MetS is significantly associated with an increased risk of developing diabetes and cardiovascular diseases (CVDs). Given that CVDs constitute by far the leading cause of morbidity and mortality worldwide, it has become essential to investigate the role played by MetS in this context to reduce the heavy burden of the disease. As such, and while MetS relatively constitutes a novel clinical entity, the extent of research about the disease has been exponentially growing in the past few decades. However, many aspects of this clinical entity are still not completely understood, and many questions remain unanswered to date. In this review, we provide a historical background and highlight the epidemiology of MetS. We also discuss the current and latest knowledge about the histopathology and pathophysiology of the disease. Finally, we summarize the most recent updates about the management and the prevention of this clinical syndrome. 相似文献
45.
N. A. Shams A. M. Kaddah E. I. Enayat Alyaa A. Shalaby A. M. Youssef 《Advanced Synthesis \u0026amp; Catalysis》1989,331(5):757-762
Reaction of acrylonitrile with 4-cyano-5,6-diphenyl pyridazin-3(2H)-one and 3(2H)-thione derivative ( 1a, b ) at elevated temperature gave 7H-5-amino-6-cyano-3,4-diphenylpyrano and thiino [2,3-c] pyridazines ( 2a, b ), respectively. However, the reaction of 4-carbethoxy pyridazine derivatives ( 1c, d ) with the same reagent, under the same conditions afforded 6H, 7H-6-cyano-3,4-diphenyl-5-oxopyrano ( 3a ) and thiino [2,3-c] pyridazine ( 3b ), respectively. In addition, treatment of ( 1a, c ) and ( 1b, d ) with acrylonitrile ar reflux in alkaline medium give the respective 3-(2′-cyanoethyloxo) ( 7a, c ) and 3-2′-cyanoethylthio ( 7b, d ) pyridazine derivatives. Prolonged alkaline hydrolysis of either ( 1a, c ) or ( 7a, c ) yielded the same product ( 8a ). Also hydrolysis of ( 1b, d ) and ( 7b, d ) afforded one and the same product ( 8b ). The structures of the products were assigned on the basis of satisfactory analytical and spectroscopic data. 相似文献
46.
H. A. Abou-Gharbia F. Shahidi A. Adel Y. Shehata M. M. Youssef 《Journal of the American Oil Chemists' Society》1997,74(3):215-221
Oxidative stability of oils extracted from intact and dehulled sesame seeds was determined by monitoring changes in fatty
acid composition, iodine value (IV), peroxide value (PV), conjugated diene (CD), para-anisidine value (p-AV), and 2-thiobarbituric acid (TBA) value and by nuclear magnetic resonance spectroscopy after storage under Schaal oven
conditions at 65°C for up to 35 d. The oils from coated seeds were more stable, as reflected in PV, CD, p-AV and TBA values, than those extracted from dehulled seeds after roasting at 200°C, steaming at 100°C, roasting at 200°C
plus steaming, or microwaving at 2450 MHz, except for TBA values of oil from microwaved seeds. After 35 d of storage at 65°C,
the CD, p-AV, and TBA values of extracted oil from dehulled microwaved seeds were 17.72, 10.20, and 1.22, respectively, while those
of their coated counterparts were significantly (P<0.05) different at 14.20, 16.47, and 1.26, respectively. Few significant changes were evident in the fatty acid composition
of oil obtained from either coated and dehulled seeds subjected to different treatments. Nuclear magnetic resonance analyses
found that Rao (aliphatic to olefinic protons) and Rad (aliphatic to diallylmethylene protons) ratios increased steadily over the entire storage period, which indicated progressive
oxidation of unsaturated fatty acids. 相似文献
47.
Hasanin Mohamed Sharmoukh Walid Hassan Youssef R. El Saied Houssni 《Journal of Inorganic and Organometallic Polymers and Materials》2022,32(2):667-677
Journal of Inorganic and Organometallic Polymers and Materials - Historically, the recording of information over paper has always been regarded as the most important factor for maintaining records... 相似文献
48.
The microbiota of commercially produced, cooked and modified atmosphere packaged poultry meat was followed during storage at 3.5 degrees C for up to 7 weeks. The dominant microbiota consisted of Lactococcus raffinolactis (117 isolates), Carnobacterium divergens (61 isolates), Carnobacterium piscicola (11 isolates), Lactococcus garvieae (four isolates), Lactococcus lactis (one isolate) and Enterococcus faecalis (three isolates). All isolates were screened for production of bacteriocins. Only C. piscicola isolates produced an inhibitory substance active against other lactic acid bacteria and against several Listeria spp. Species-specific polymerase chain reaction (PCR) primers were used for the differentiation of Carnobacterium, L. raffinolactis, L. lactis, and L. garvieae strains associated with the modified atmosphere packaged poultry products. No false PCR products were observed with other closely related bacterial species. 相似文献
49.
Synthesis of Novel Series of Benzothieno [2,3-d] Pyrimidine Derivatives, Promising Anticancer Agents
Omer Khalid AI-Duaij Hend Nagah Hafez Abdel-Rhman Barakat Ahmed EI-Gazzar 《化学与化工:英文版》2013,(8):725-742
An extension of the authors' previous discovery of in vitro antitumor activity of substituted thino [2,3-d] prymidine derivatives is reported. The synthesis of some new spirothino [2,3-d] prymidine (4a-f), imidazolidin, substituted prymidinyl and substituted thiazolidine thino [2,3-d] prymidine derivatives have been described. Thirteen of the obtained compounds were selected by the NCI and evaluated for their in vitro anticancer activity. Seven of the investigated compounds, 4a, 8a, 9a, (12a, b), 14a and 15a, displayed high anticancer activity in the primary assay. These compounds have been selected for a full anticancer screening against a 60-cell panel assay where they showed non-selective broad spectrum and promising activity against all cancer cell lines. Compounds 12a and 12b proved to be the active members in this study compared to 5-fluorouracil and cyclophosphamide as reference drugs, respectively. Compounds 12a and 12b were identified as promising lead compounds, evaluated for their in-vitro antitumor activity. 相似文献
50.
Hierarchial Zeolites: Beyond Creation of Mesoporosity: The Advantages of Polymer‐Based Dual‐Function Templates for Fabricating Hierarchical Zeolites (Adv. Funct. Mater. 12/2016)
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