Light‐Controlled Reversible Manipulation of Microgel Particle Size Using Azobenzene‐Containing Surfactant

The light‐induced reversible switching of the swelling of microgel particles triggered by photo‐isomerization and binding/unbinding of a photosensitive azobenzene‐containing surfactant is reported. The interactions between the microgel (N‐isopropylacrylamide, co‐monomer: allyl acetic acid, crosslinker: N,N′‐methylenebisacrylamide) and the surfactant are studied by UV‐Vis spectroscopy, dynamic and electrophoretic light scattering measurements. Addition of the surfactant above a critical concentration leads to contraction/collapse of the microgel. UV light irradiation results in trans‐cis isomerization of the azobenzene unit incorporated into the surfactant tail and causes an unbinding of the more hydrophilic cis isomer from the microgel and its reversible swelling. The reversible contraction can be realized by blue light irradiation that transfers the surfactant back to the more hydrophobic trans conformation, in which it binds to the microgel. The phase diagram of the surfactant‐microgel interaction and transitions (aggregation, contraction, and precipitation) is constructed and allows prediction of changes in the system when the concentration of one or both components is varied. Remote and reversible switching between different states can be realized by either UV or visible light irradiation.     

Pseudotransient Continuation-Based Steady State Solver: Extension to Zero Flow Rates

This paper presents and discusses an extension of the pseudotransient continuation-based steady state solver for hydraulic networks proposed previously to the case of zero flow rates. The original solver, which reduces the solution of the governing nonlinear algebraic equations to the numerical integration of an initial-value problem, has problems in situations in which the head derivative of the flow rate tends to infinity, as is the case with zero flow rates. The extension is on the basis of the use of a model headloss-flow relationship that coincides with the true one at zero and has a finite head derivative at that point. This modified steady state solver is free from some convergence problems that occur in Newton-Raphson method-based solvers when analyzing a pipe network with control devices. The paper includes the results of the numerical analysis of test networks, which demonstrate the convergence of the modified steady state solver for cases in which existing steady state solvers have troubles.     

Clever Nuclear Fuel Technology

The purpose of given article-consideration of the basic features of modern manufacturing of nuclear fuel which would confirm fact, that the manufacturer does everything that its production would respond not only to requirements of the consumer, but also to its expected inquiries, and would correspond to intended purposes of fuel. It was defined main tendencies and features of modern technology, especially in nuclear fuel production, on base of meeting discussions, themes of journal articles on nuclear subject. They are correspond with practice of JSC NCCP （Novosibirsk Chemical Concentrates Plant） and listed in the paper. In result of it number of base features of any advanced technology, not only nuclear, described here with examples from NCCP＇s practice. Of course, there is no certain list of all attributes of modern manufacturing as there is no limit to its perfection. These categories are forming by current needs of the market, but listed ones must be.     

Nanocomposite protective coatings based on Ti–N–Cr/Ni–Cr–B–Si–Fe,their structure and properties

The first results of manufacturing and investigations of a new type of nanocomposite protective coatings are presented. They were manufactured using a combination of two technologies: plasma-detonation coating deposition with the help of plasma jets and thin coating vacuum-arc deposition. We investigated structure, morphology, physical and mechanical properties of the coatings of 80–90 μm thickness, as well as defined the hardness, elastic Young modulus and their corrosion resistance in different media. Grain dimensions of the nanocomposite coatings on Ti–N–Cr base varied from 2.8 to 4 nm. The following phases and compounds formed as a result of plasma interaction with the thick coating surface were found in the coatings: Ti–N–Cr (200), (220), γ-Ni₃–Fe, a hexagonal Cr₂–Ti, Fe₃–Ni, (Fe, Ni)N and the following Ti–Ni compounds: Ti₂Ni, Ni₃Ti, Ni₄Ti, etc. We also found that the nanocomposite coating microhardness increased to H = 31.6 ± 1.1 GPa. The Young elastic modulus was determined to be E = 319 ± 27 GPa – it was derived from the loading–unloading curves. The protective coating demonstrated the increased corrosion resistance in acidic and alkaline media in comparison with that of the stainless steel substrate.     

A Novel Photoswitchable Azobenzene-Containing Local Anesthetic Ethercaine with Light-Controlled Biological Activity In Vivo

Pain is a common symptom that impairs the quality of life for people around the world. Local anesthetics widely used for pain relief have a number of side effects, which makes the development of both new drugs and new ways to control their activity particularly important. Photopharmacology makes it possible to reduce the side effects of an anesthetic and control its biological activity in the body. The purpose of this work was to create a new light-controlled local anesthetic and study its biological activity in animals. A compound with a simple scheme of synthesis was chosen to shift the UV-Vis absorption band towards the visible range of the spectrum and was synthesized for the first time. Some computer calculations were performed to make sure that the aforementioned changes would not lead to loss of biological activity. The micellar form of the new compound was prepared, and in vivo biological studies were carried out in rabbits. The existence of a local anesthetic effect, which disappeared almost completely on irradiation with light (λ = 395 nm), was shown using the surface anesthesia model. Moreover, the possibility of multiple reversible changes in the biological activity of ethercaine under the action of light was demonstrated. The latter compound manifests no local irritating effect, either. The data obtained indicate the prospects for the development of new compounds based on azobenzene for light-controlled local anesthesia.     

Do automated program repair techniques repair hard and important bugs?

Existing evaluations of automated repair techniques focus on the fraction of the defects for which the technique can produce a patch, the time needed to produce patches, and how well patches generalize to the intended specification. However, these evaluations have not focused on the applicability of repair techniques and the characteristics of the defects that these techniques can repair. Questions such as “Can automated repair techniques repair defects that are hard for developers to repair?” and “Are automated repair techniques less likely to repair defects that involve loops?” have not, as of yet, been answered. To address such questions, we annotate two large benchmarks totaling 409 C and Java defects in real-world software, ranging from 22K to 2.8M lines of code, with measures of the defect’s importance, the developer-written patch’s complexity, and the quality of the test suite. We then analyze relationships between these measures and the ability to produce patches for the defects of seven automated repair techniques —AE, GenProg, Kali, Nopol, Prophet, SPR, and TrpAutoRepair. We find that automated repair techniques are less likely to produce patches for defects that required developers to write a lot of code or edit many files, or that have many tests relevant to the defect. Java techniques are more likely to produce patches for high-priority defects. Neither the time it took developers to fix a defect nor the test suite’s coverage correlate with the automated repair techniques’ ability to produce patches. Finally, automated repair techniques are less capable of fixing defects that require developers to add loops and new function calls, or to change method signatures. These findings identify strengths and shortcomings of the state-of-the-art of automated program repair along new dimensions. The presented methodology can drive research toward improving the applicability of automated repair techniques to hard and important bugs.     

First-principles modeling for optimal design,operation, and integration of energy conversion and storage systems

Energy and electricity consumption is expected to increase in the foreseeable future. Concurrently, sustainability concerns of fossil-based energy resources have motivated the use of renewable and reusable energy resources, and the use of more efficient energy-converting and energy-consuming systems. Consequently, for the past decade, there have been major theoretical and experimental advances in (1) energy generation from renewable and reusable resources and (2) energy-consuming and energy-converting devices. This review article focuses on the recent theoretical advances in renewable energy conversion devices such as photovoltaic and fuel cells, and in energy storage devices such as rechargeable batteries, flow batteries, and supercapacitors. Due to similar chemistry, electrochemistry, and physics of these systems, modeling similarities between different energy systems are highlighted. This review puts into perspective how first-principles mathematical modeling has contributed to systematic advances in the optimal design, operation, and integration of these systems. © 2018 American Institute of Chemical Engineers AIChE J, 65: e16482 2019     

Characterization of free carbon forms in β-SiC nanopowders by temperature-programmed oxidation and Raman spectroscopy

Free carbon appears in β-SiC nanopowders as two-dimensional and ultrathin structures exposed predominantly on particle surfaces. These structures range from graphitic to lamella and amorphous, with more than one type being present at once. Their relative proportions and total percentage are quantified based on CO₂ evolution traces resulting from temperature-programmed oxidation (TPO). The TPO peak parameters are representative of the carbon nanostructure. The temperature of the peak maximum relates to the degree of graphitic order, whereas an apparent activation energy to structure homogeneity. Among the Raman parameters (for a 514-nm excitation wavelength), the area ratio of the D and G + D′ lines closely correlates with the relative proportion and structural perfection of the graphitic form. Furthermore, the area ratio of the β-SiC and carbon Raman lines is a strong function of the free carbon content in the range 0.1 to 5 wt%. The established correlations provide a guide to the consistent implementation of both techniques to characterize mixed carbon forms in β-SiC nanopowders.     

Mikrowelleninduzierte Thermolyse von Erdöl unter der Einwirkung von heterogenen Katalysatoren

The first oil‐producing regions in the human history were located near Baku. Until the beginning of the 20th century, the Balachany‐Sabuncu‐Ramany region produced more than 60 % of Baku's oil. This oil sources are largely exploited and contain yet only heavy extractable fractions of crude oil. Experiments with oil samples from this oil fields show, that irradiation with microwaves under addition of magnetite catalysts leads to a reduction of petroleum viscosity. It seems to be a new attempt for intensive extraction of petroleum.