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61.
Platelet-activating factor (PAF) is a proinflammatory phospholipid mediator implicated in necrotizing enterocolitis. Regulation of PAF-acetylhydrolase (AH), the enzyme degrading PAF, is poorly understood. In this study we found that administration of a dose of PAF (1.5 microg/kg, i.v.), which does not cause gross intestinal injury, increased plasma and intestinal PAF-AH in the rat. Cycloheximide (CHX, 5 mg/kg, i.v.) reduced the activity of plasma (but not intestinal tissue) AH in control, as well as in PAF-injected rats, and aggravated systemic inflammation and tissue injury in the latter. The intestinal necrosis induced by PAF and CHX was ameliorated by posttreatment with WEB2170 (a PAF antagonist), indicating a role of endogenous PAF in mediating injury. Both WEB2170 and anti-TNF antibody reduced PAF-induced AH activity in intestinal tissue, but not in the plasma. Allopurinol largely prevented the injury induced by PAF and CHX, but had no effect on the up-regulation of AH. We conclude: 1) de novo protein synthesis is required to maintain physiologic AH level in the plasma; 2) PAF up-regulates plasma and intestinal AH activity; 3) CHX enhances the injurious effect of PAF; 4) endogenous PAF and TNF also play a role in the up-regulation of intestinal AH; the former probably mediating the intestinal injury by PAF; and 5) reactive oxygen species may mediate the injurious effect of PAF plus CHX, but do not contribute to the regulation of AH by PAF. 相似文献
62.
63.
Recently, numerous attempts have been made by researchers to understand the essence of complex phenomena (complex systems). In this paper, we consider biological systems in nature as being among the most complex systems. The purpose of this paper is to propose a method of realizing symbiotic phenomena such as mutual benefit, competition, and exploitation more generally than the Lotka–Volterra equation by using neural networks. © 2002 Wiley Periodicals, Inc. Electr Eng Jpn, 140(1): 77–88, 2002; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.1172 Copyright © 2002 Scripta Technica 相似文献
64.
G Tsujimoto A Hirasawa T Sugawara T Awaji 《Canadian Metallurgical Quarterly》1998,62(17-18):1567-1571
Chlorethylclonidine (CEC) inactivation has been used as one criterion to subclassify the alpha1-adrenoceptors (AR); however, the extent of CEC inactivation can vary depending on the CEC treatment. By constructing the FLAG-tagged (N-terminus) and green fluorescent protein (GFP)-fused (C-terminus) alpha1-ARs, we have determined the relationship between CEC sensitivity and the cellular localization of alpha1-AR subtypes using COS-7 cells. In GFP-expressing cells, flow cytometry analysis with anti-FLAG N-terminus antibody detected strong fluorescent signals in most of alpha1B-AR-expressing cells, but low signals in alpha1A-AR-expressing cells. Further examination with confocal microscopy showed that fluorescent signals densely localized intra-cellularly in alpha1A-AR-expressing cells, while most of alpha1B-AR localized on the cell surface. Furthermore, radioligand binding studies with [125I]HEAT showed that CEC (10 microM) treatment of intact cells inactivated approximately 30-40% of alpha1A-AR and >90% of alpha1B-AR, while the CEC treatment of membrane preparations resulted in >80% decrease in the alpha1A-AR density and >90% of alpha1B-AR density, respectively. The results showed that the hydrophilic alkylating agent CEC inactivated only alpha1-AR on the cell surface irrespective of its subtype, and that the subtype-specific sorting is a major determinant for CEC inactivation of alpha1-AR. Subtype-specific cellular localization suggests a new class of functional properties that may explain the signal and functional diversity of homologous alpha1-AR (as well as other G protein-coupled receptors) subtypes. 相似文献
65.
Saito H. Saito F. Yuta S. Nakajima M. 《IEEE transactions on instrumentation and measurement》1990,39(5):739-744
A method of high-speed data collection used in imaging the magnetic-field distribution leaking from magnetic devices along any plane is proposed. The method uses the computed tomography (CT) technique. A high-speed data collection system developed for demonstrating the method is described. An image of the magnetic field is reconstructed from projection data provided by the voltage induced in the sensors of a line conductor and a rectangular coil moving in the plane of observation. Rotational scanning of the sensors is used for collecting the projections so that data-acquisition time can be reduced. To demonstrate the performance of the system, the reconstructed images of the magnetic-field distributions made by some permanent magnets are shown 相似文献
66.
The hydrothermal reactions of fibrous H2Ti4O9 particles with Ba(OH)2 solution in the presence of cationic surfactants of n-hexadecyltrimethylammonium hydroxide (HTMA-OH) and n-hexadecyltrimethylammonium
bromide (HTMA-Br) were investigated in a temperature range of 150–250 °C. H2Ti4O9 phase with layered structure was transformed to BaTiO3 phase in the Ba(OH)2–(HTMA-OH) and the Ba(OH)2–(HTMA-Br) solutions, and partially transformed to anatase phase in the Ba2+-free HTMA-OH and HTMA-Br solutions by topotactic structural transformation reactions under the hydrothermal conditions. The
cocoon-like BaTiO3 and titanium oxide particles were obtained after the hydrothermal reactions in the Ba(OH)2–(HTMA-OH) and HTMA-OH solution, respectively. These cocoon-like particles were formed by assembling the fibrous particles
in the surfactant solutions. 相似文献
67.
The reaction mechanisms of a stage-1 fluorine-graphite intercalation compound (GIC), C2.5F, with 0.10 MPa of fluorine gas have been studied at 573-773 K. The original stage-1 structure of C2.5F with semi-ionic C-F bonds and planar sp2 carbon sheets is maintained in most part of the compound after the reaction at 573 K, although a large number of covalent C-F bonds are formed on the surface. This compound is partially or completely converted to poly(carbon monofluoride), (CF)n, with covalent C-F bonds and puckered sp3 carbon sheets at 673 or 773 K, respectively. Single-phase (CF)n obtained at 773 K possesses remarkably small BET specific surface area, 61 m2/g carbon, almost unchanged from the value of the precursor C2.5F (69 m2/g carbon). In this reaction, the accommodation of fluorine atoms supplied from the atmosphere into the galleries of C2.5F is facilitated by the rearrangement of originally intercalated fluorine atoms in the GIC, forming (CF)n with fewer defects compared to those by the conventional direct fluorination of graphite. 相似文献
68.
Tomio Chiba Mitsuyasu Kido Junzou Kawakami Katsuhiko Yoneda Tadao Kawai Kotaro Hirasawa 《Electrical Engineering in Japan》1994,114(5):31-43
Control and protection equipment in power systems requires higher sensitivity and operational reliability to meet today's changing power system requirements. The voltage-measuring deviation requirement for advanced voltage and var control equipment is less than 0.1 percent under conditions of harmonic distortion in the voltage waveform and power-system frequency variation. Studies on digital signal processing suitable for electric power systems showed that these requirements are satisfied using fast sampling and very fast 32-bit floating point operations by a Digital Signal Processor (DSP). This paper describes the design philosophy of a high-precision power system voltage-measuring method using fast sampled data. In addition, total voltage-measuring deviation characteristics under a combination of the techniques are described along with digital filter characteristics, frequency-measuring deviation characteristics, frequency variation versus gain-compensation characteristics of a digital filter, and peak value operating principles. 相似文献
69.
Antenna array optimization by a biquadratic programming method is formulated with variable-phase (analog and digital) and constant amplitude excitation. The method can optimize an antenna performance index expressible as a ratio of Hermitian quadratic forms. Power gain optimization and least-squares pattern synthesis with a specified gain are illustrated. Linear, planar, and circular arrays with dipole or circular loop elements are optimized, taking mutual coupling effects between antenna elements into account. The method shows much more rapid convergence characteristics than the Rosenbrock (1960) and Fletcher-Power (1963) methods 相似文献
70.