Asymptotic properties on codeword lengths of an optimal FV code for general sources

This correspondence is concerned with asymptotic properties on the codeword length of a fixed-to-variable length code (FV code) for a general source {X/sup n/}/sub n=1//sup /spl infin// with a finite or countably infinite alphabet. Suppose that for each n /spl ges/ 1 X/sup n/ is encoded to a binary codeword /spl phi//sub n/(X/sup n/) of length l(/spl phi//sub n/(X/sup n/)). Letting /spl epsiv//sub n/ denote the decoding error probability, we consider the following two criteria on FV codes: i) /spl epsiv//sub n/ = 0 for all n /spl ges/ 1 and ii) lim sup/sub n/spl rarr//spl infin///spl epsiv//sub n/ /spl les/ /spl epsiv/ for an arbitrarily given /spl epsiv/ /spl isin/ [0,1). Under criterion i), we show that, if X/sup n/ is encoded by an arbitrary prefix-free FV code asymptotically achieving the entropy, 1/nl(/spl phi//sub n/(X/sup n/)) - 1/nlog/sub 2/ 1/PX/sup n/(X/sup n/) /spl rarr/ 0 in probability as n /spl rarr/ /spl infin/ under a certain condition, where P/sub X//sup n/ denotes the probability distribution of X/sup n/. Under criterion ii), we first determine the minimum rate achieved by FV codes. Next, we show that 1/nl(/spl phi//sub n/(X/sup n/)) of an arbitrary FV code achieving the minimum rate in a certain sense has a property similar to the lossless case.     

H optimal approximation for causal spline interpolation

In this paper, we give a causal solution to the problem of spline interpolation using H^∞ optimal approximation. Generally speaking, spline interpolation requires filtering the whole sampled data, the past and the future, to reconstruct the inter-sample values. This leads to non-causality of the filter, and this becomes a critical issue for real-time applications.Our objective here is to derive a causal system which approximates spline interpolation by H^∞ optimization for the filter. The advantage of H^∞ optimization is that it can address uncertainty in the input signals to be interpolated in design, and hence the optimized system has robustness property against signal uncertainty.We give a closed-form solution to the H^∞ optimization in the case of the cubic splines. For higher-order splines, the optimal filter can be effectively solved by a numerical computation. We also show that the optimal FIR (finite impulse response) filter can be designed by an LMI (linear matrix inequality), which can also be effectively solved numerically. A design example is presented to illustrate the result.     

Direct modulation of InGaAsP/InP double heterostructure lasers

Direct modulation of an InGaAsP/InP double heterostructure laser was investigated experimentally. Sinusoidal modulation up to 2.5 GHz was achieved with almost constant modulation efficiency. Pulse responses showed that the damped relaxation oscillation in light output was well suppressed.     

Detonation propagation in narrow gaps with various configurations

In general all detonation waves have cellular structure formed by the trajectory of the triple points.This paperaims to investigate experimentally the propagation of detonation in narrow gaps for hydrogen-oxygen-argonmixtures in terms of various gap heights and gap widths.The gap of total length 1500 mm was constructed bythree pair of stainless plates,each of them was 500 mm in length,which were inserted in a detonation tube.Thegap heights were varied from 1.2 mm to 3.0 mm while the gap widths were varied from 10 mm to 40 mm.Variousargon dilution rates were tested in the present experiments to change the size of cellular structure.Attempts havebeen made by means of reaction front velocity,shock front velocity,and smoked foil to record variations of cel-lular structure inside the gaps.A combination probe composed of a pressure and an ion probe detected the arrivalof the shock and the reaction front individually at one measurement point.Experimental results show that thenumber of the triple points contained in detonation front decreases with decrease in the gap heights and gapwidths,which lead to larger cellular structures.For mixtures with low detonability,cell size is affected by a cer-tain gap width although conversely cell size is almost independent of gap width.From the present result it wasfound that detonation propagation inside the gaps is strongly governed by the gap height and effects of gap widthis dependent on detonability of mixtures.     

Harmonic blue light generation in periodically poled bulk near-stoichiometric MgO:LiNbO/sub 3/

A periodically poled structure with 6.95 /spl mu/m period and 10 mm interaction length was fabricated in a 1 mm-thick 1.8 mol% MgO doped near-stoichiometric LiNbO/sub 3/ (MgSLN) by using a multi-pulse poling technique. Blue SHG characteristics of this periodically poled MgSLN were investigated, in comparison with a periodically poled 5 mol% MgO doped congruent LiNbO/sub 3/.     

Statistical analysis on stimulated Raman crosstalk in dispersion-managed fiber links

Power impairments due to stimulated Raman scattering (SRS) in dispersion-managed (DM) fiber links are evaluated theoretically. We extend previous work on the statistical analysis of SRS crosstalk to the case of multiple fiber segments. Closed-form formulas are derived, and the applicable range is presented by comparison with simulation results. The SRS crosstalk in DM fiber links is evaluated using derived formulas, and the preferable configuration of DM fiber links for suppressing SRS crosstalk is discussed. We also evaluate the exact power penalty induced by the SRS crosstalk in consideration of the log-normal waveform distribution due to SRS and non-Gaussian noise and clarify the system bounds in some typical DM fiber links. The developed approach provides a design rule for DM fiber links from the viewpoint of SRS crosstalk suppression.     

Sulfated Hyaluronan Binds to Heparanase and Blocks Its Enzymatic and Cellular Actions in Carcinoma Cells

We examined whether sulfated hyaluronan exerts inhibitory effects on enzymatic and biological actions of heparanase, a sole endo-beta-glucuronidase implicated in cancer malignancy and inflammation. Degradation of heparan sulfate by human and mouse heparanase was inhibited by sulfated hyaluronan. In particular, high-sulfated hyaluronan modified with approximately 2.5 sulfate groups per disaccharide unit effectively inhibited the enzymatic activity at a lower concentration than heparin. Human and mouse heparanase bound to immobilized sulfated hyaluronan. Invasion of heparanase-positive colon-26 cells and 4T1 cells under 3D culture conditions was significantly suppressed in the presence of high-sulfated hyaluronan. Heparanase-induced release of CCL2 from colon-26 cells was suppressed in the presence of sulfated hyaluronan via blocking of cell surface binding and subsequent intracellular NF-κB-dependent signaling. The inhibitory effect of sulfated hyaluronan is likely due to competitive binding to the heparanase molecule, which antagonizes the heparanase-substrate interaction. Fragment molecular orbital calculation revealed a strong binding of sulfated hyaluronan tetrasaccharide to the heparanase molecule based on electrostatic interactions, particularly characterized by interactions of (−1)- and (−2)-positioned sulfated sugar residues with basic amino acid residues composing the heparin-binding domain-1 of heparanase. These results propose a relevance for sulfated hyaluronan in the blocking of heparanase-mediated enzymatic and cellular actions.     

Mutated KIT Tyrosine Kinase as a Novel Molecular Target in Acute Myeloid Leukemia

KIT is a type-III receptor tyrosine kinase that contributes to cell signaling in various cells. Since KIT is activated by overexpression or mutation and plays an important role in the development of some cancers, such as gastrointestinal stromal tumors and mast cell disease, molecular therapies targeting KIT mutations are being developed. In acute myeloid leukemia (AML), genome profiling via next-generation sequencing has shown that several genes that are mutated in patients with AML impact patients’ prognosis. Moreover, it was suggested that precision-medicine-based treatment using genomic data will improve treatment outcomes for AML patients. This paper presents (1) previous studies regarding the role of KIT mutations in AML, (2) the data in AML with KIT mutations from the HM-SCREEN-Japan-01 study, a genome profiling study for patients newly diagnosed with AML who are unsuitable for the standard first-line treatment (unfit) or have relapsed/refractory AML, and (3) new therapies targeting KIT mutations, such as tyrosine kinase inhibitors and heat shock protein 90 inhibitors. In this era when genome profiling via next-generation sequencing is becoming more common, KIT mutations are attractive novel molecular targets in AML.     

Development and Evaluation of a Robust Sandwich Immunoassay System Detecting Serum WFA-Reactive IgA1 for Diagnosis of IgA Nephropathy

Aberrant glycosylation of IgA1 is involved in the development of IgA nephropathy (IgAN). There are many reports of IgAN markers focusing on the glycoform of IgA1. None have been clinically applied as a routine test. In this study, we established an automated sandwich immunoassay system for detecting aberrant glycosylated IgA1, using Wisteria floribunda agglutinin (WFA) and anti-IgA1 monoclonal antibody. The diagnostic performance as an IgAN marker was evaluated. The usefulness of WFA for immunoassays was investigated by lectin microarray. A reliable standard for quantitative immunoassay measurements was designed by modifying a purified IgA1 substrate. A validation study using multiple serum specimens was performed using the established WFA-antibody sandwich automated immunoassay. Lectin microarray results showed that WFA specifically recognized N-glycans of agglutinated IgA1 in IgAN patients. The constructed IgA1 standard exhibited a wide dynamic range and high reactivity. In the validation study, serum WFA-reactive IgA1 (WFA+-IgA1) differed significantly between healthy control subjects and IgAN patients. The findings indicate that WFA is a suitable lectin that specifically targets abnormal agglutinated IgA1 in serum. We also describe an automated immunoassay system for detecting WFA+-IgA1, focusing on N-glycans.     

Room temperature c.w. operation of InGaAsP/InP heterostructure lasers emitting at 1.56 ?m

Room-temperature c.w. operation of InGaAsP/InP heterostructure lasers grown by liquid-phase epitaxy was achieved at 1.56 ?m. An active InGaAsP layer was essentially sandwiched by InP, though a thin InGaAsP buffer layer was deposited to prevent the melt-back of the active layer. Threshold current was typically 300 mA for a 17 ?m wide oxide-defined stripe laser.