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41.
42.
In brain disorders, reactive astrocytes, which are characterized by hypertrophy of the cell body and proliferative properties, are commonly observed. As reactive astrocytes are involved in the pathogenesis of several brain disorders, the control of astrocytic function has been proposed as a therapeutic strategy, and target molecules to effectively control astrocytic functions have been investigated. The production of brain endothelin-1 (ET-1), which increases in brain disorders, is involved in the pathophysiological response of the nervous system. Endothelin B (ETB) receptors are highly expressed in reactive astrocytes and are upregulated by brain injury. Activation of astrocyte ETB receptors promotes the induction of reactive astrocytes. In addition, the production of various astrocyte-derived factors, including neurotrophic factors and vascular permeability regulators, is regulated by ETB receptors. In animal models of Alzheimer’s disease, brain ischemia, neuropathic pain, and traumatic brain injury, ETB-receptor-mediated regulation of astrocytic activation has been reported to improve brain disorders. Therefore, the astrocytic ETB receptor is expected to be a promising drug target to improve several brain disorders. This article reviews the roles of ETB receptors in astrocytic activation and discusses its possible applications in the treatment of brain disorders. 相似文献
43.
Naoki Horiguchi Hiroyuki Yoshida Yutaka Abe 《Journal of Nuclear Science and Technology》2019,56(3):278-290
Venturi scrubbers for filtered venting have been installed in nuclear power plants worldwide. Venturi scrubbers can eliminate fission products from a polluted gas by interaction through gas–liquid interfaces. Therefore, droplet diameter is important from the viewpoint of decontamination. When Venturi scrubbers are used in severe accidents, the gas flow velocity might be extremely high. In these studies, the authors did not measure droplet diameter under extremely high gas velocity conditions. In the scenarios, experimental data pertaining to droplet diameter, under the extremely high gas flow velocity, are required. Therefore, this objective is to evaluate the diameter of extremely high-speed droplets. A visualization experiment was conducted using a Venturi scrubber. The droplet diameter distribution and the Sauter mean diameter (SMD) were determined. By comparing between the experimental value of SMDs and the one evaluated using Nukiyama–Tanasawa equation, it was confirmed that the Nukiyama–Tanasawa equation can be used to evaluate SMD with good accuracy in the gas velocity range of 82–250 m/s, except the highest gas velocity conditions. Furthermore, the droplet generation mechanism in the Venturi scrubber was considered to clarify the main reason why the Nukiyama–Tanasawa equation can be used to evaluate SMD droplet diameter. 相似文献
44.
Yutaka Kawahara Atsushi Nakayama Masatoshi Shioya Masaki Tsuji Hideki Yamane Tadahisa Iwata 《Journal of Materials Science》2012,47(4):1887-1892
Structure of poly(dioxanone) (PPDX) fibers produced through a two-step melt-spinning process with an additional short-period
annealing above the melting temperature of PPDX was investigated and the effect of annealing on the degradation behavior was
discussed. The morphological study carried out by etching the fibers using a phosphate or permanganate solution suggested
that the fibers take a skin–core structure, and both the skin layer and the core region consist of a bundle of microfibrils.
The micro-beam X-ray diffraction analysis revealed that the short-period annealing in the production process only slightly
promotes the crystallization in the skin layer but contributes to increasing the packing of amorphous chains near the skin,
which seems to be the controlling factor of the hydrolytic degradation behavior of the fibers. 相似文献
45.
Yosuke Ue Ryoichi Hara Hiroyuki Kita Yutaka Saito Katsuyuki Takitani Masami Saito 《Electrical Engineering in Japan》2012,180(3):55-63
Photovoltaic (PV) systems are attracting attention as one of the promising countermeasures against global warming and the environmental issues. However, the generation output from PV systems is generally unstable and unpredictable. Therefore, large penetration of PV systems may cause some serious impacts on power system operation, such as load frequency control, voltage regulation, etc. Estimation of the influences of PV system installation is becoming important, but it requires simultaneous multipoint solar radiation measurements. The Japan Meteorological Business Support Center has provided 1‐minute meteorological data observed in Japan, but its solar radiation data includes quantization errors. This paper proposes a regeneration method for solar radiation data including quantization errors. It also analyzes the spatial smoothing effect of global solar radiation fluctuations. © 2012 Wiley Periodicals, Inc. Electr Eng Jpn, 180(3): 55–63, 2012; Published online in Wiley Online Library ( wileyonlinelibrary.com ). DOI 10.1002/eej.21274 相似文献
46.
47.
Daisuke Kawashima Yutaka Asako 《International Journal of Heat and Mass Transfer》2012,55(9-10):2244-2248
This paper focuses on temperature rise due to the viscous dissipation in liquids flowing through micro-channels. In the past, equations for the prediction of the temperature rise have been obtained as a function of the friction factor, Reynolds number and Eckert number or a similar form, starting from Navier–Stokes equation and energy equation under the assumption of fully developed laminar flow by researchers. The temperature rises calculated from the equations have been compared with experimental data and the equations have been validated. However, in this paper, a new equation for the prediction of the temperature rise is simply obtained from the first law of thermodynamics without restriction of fully developed laminar flow. 相似文献
48.
Midori Takasaki Kentaro Hara Yutaka Ohkoshi Takayuki Fujii Hiroyasu Shimizu Masaharu Saito 《Polymer Engineering and Science》2014,54(11):2605-2609
Thermoplastic polyurethane fiber webs were prepared using a laser‐heated electrospinning process combined with air blowing. The effect of spinning conditions such as air flow rate and air temperature on fiber diameter and molecular weight was investigated. Although the average fiber diameter decreased with increased air flow rate at each air temperature, the diameter increased when the air flow rate was >15 NL min?1. In addition, the fiber was comparatively thicker with an increase in the air temperature. The variation in the fiber diameter tends to increase with the air flow rate, and a reduction in the molecular weight of the fiber by thermal degradation was suppressed. The thinnest and most uniform fiber with a diameter of 0.9 µm and a diameter coefficient variation of 15% was obtained at an air temperature of 25°C under an air flow rate of 15 NL min?1. This fiber also had a minimum of decreased molecular weight. POLYM. ENG. SCI., 54:2605–2609, 2014. © 2013 Society of Plastics Engineers 相似文献
49.
Structure and mechanical properties of multi‐hollowed fibers produced by CO2 laser irradiated neck drawing
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Young‐Ah Kang Xin Zhao Yutaka Ohkoshi Kyoung Hou Kim 《Polymer Engineering and Science》2016,56(6):609-616
Multi‐hollowed fibers with a hollowness ratio of over 20% were successfully produced using a neck‐drawing technique accompanied by CO2 laser irradiation on unoriented and amorphous polytrimethylene terephthalate (PTT) fibers with diameters of approximately 104 µm. The structure and mechanical properties of the multi‐hollowed fibers were characterized using scanning electron microscopy, wide angle X‐ray diffraction (WAXD), birefringence measurements, and tensile tests. Crystal orientation factors in the direction normal to the (010) and (002) planes, which were obtained from WAXD patterns, were lower in comparison to values obtained in previous studies on fibers that did not feature these hollows [9] because of the development of these internal hollows. The PTT fibers in this study also displayed high toughness, about 465 MPa (3.5 cN/dtex) strength and about 40% elongation, and had excellent elastic recovery (>95%) after 10 stretch cycles. POLYM. ENG. SCI., 56:609–616, 2016. © 2015 Society of Plastics Engineers 相似文献
50.
In this paper, photoresponsive behavior of multi-bilayered films having precisely controlled layer thickness prepared by stacking an azo-functionalized polymer liquid crystal, PMAzXAc, and polyvinyl alcohol alternatively, PVA, is described. The multi-bilayered films were found to reflect a light of specific wavelength depending on the layer thickness and refractive index, and showed the reversible change in the reflection intensity by irradiation with visible and UV lights. The change in the reflection intensity was brought about by change in the molecular orientation of PMAzXAc between an out-of-plane orientation and a photo-induced isotropic state, and was strongly dependent on the number of methylene spacer of PMAzXAc linking the azobenzene side group with the acrylate polymer main chain. PMAz6Ac with hexa-methylene spacer showed the largest change in the reflection intensity, while smaller change in the reflection intensity was observed for PMAzXAc having shorter or longer methylene spacer than 6. The effect of the methylene spacers on the photochemical change in the molecular orientation of azobenzene chromophores in the multi-bilayered films will be discussed. 相似文献