基于jBPM4的临时动态性需求研究

介绍了国内目前的工作流领域特点,尤其对临时动态性需求(会签、撤销、任意回退等)的各种场景进行了分析,提出了基于jBPM4的解决思路及一种动态路由的方法,以解决临时回退的问题.     

Bortezomib Dendrimer Prodrug‐Based Nanoparticle System

Bortezomib (BTZ) is mainly used to treat hematologic tumors, such as multiple myeloma and small cell lymphoma. However, its usefulness for solid tumor therapy is limited owing to its poor stability and toxicity in vivo. In the present study, an amphiphilic PEGylated dendrimer with dopamine molecule is synthesized from azide group–functionalized polyethylene glycol and alkyne group–functionalized dendrimer, which is produced from 1,1‐dimethylolpropionic acid and dopamine. The amphiphilic PEGylated dendrimer with dopamine molecule reacts with BTZ to construct a BTZ prodrug‐based nanoparticle through a ultrasonic emulsification method. The BTZ prodrug‐based nanoparticles have greater serum stability than BTZ alone and release the prototype drug in acidic environments. The BTZ prodrug‐based nanoparticle is more effective against subcutaneous tumors than BTZ itself. Furthermore, c(RGDyK) modification significantly improves the antitumor efficacy of the BTZ prodrug‐based nanoparticle with regard to subcutaneous and intracranial tumors. Moreover, the BTZ prodrug‐based nanoparticle significantly reduces the toxicity of BTZ in vivo. Therefore, the PEGylated BTZ dendrimer prodrug‐based nanoparticles have great potential for the treatment of solid tumors in vivo.     

Solvent-vapor induced self-assembly of a conjugated polymer: A correlation between solvent nature and transistor performance

A systematical investigation on solvent-vapor annealing in polymer thin film transistors is performed using a thiazolothiazole-bithiazole conjugated polymer as the active layer. Film morphology, packing order and device performance are closely related to polarity and solubility parameter of the annealing solvent and annealing time. The formation of highly ordered and closely connected fibrillar domains is realized by using a solvent with similar solubility parameter and polarity to the conjugated polymer. Field-effect transistors based on pristine polymer films exhibit a highest charge carrier mobility of 0.0067 cm² V⁻¹ s⁻¹. After solvent vapor annealing with THF for 48 h, the mobility boosts up to 0.075 cm² V⁻¹ s⁻¹. This correlation between solvent polarity, solubility parameter and film morphology, packing order and mobility provides a useful guideline towards high performance polymer thin film transistors with solvent-vapor annealing method.     

快速心肌显像剂^99mTc—TEBO的标记和动物体内分布实验

报道了用＾９９ｍＴｃ标记Ｔｅｂｏｒｏｘｉｍｅ（简称ＴＥＢＯ），并在标记后对其质量进行了鉴定。结果表明，其物理性质、化学性质及生物学性质均符合国家制定的放射性药物的质量标准；动物实验表明，小鼠注射量为成人用量的１００倍、观察１５天后，实验组和对照组无差别；注入量为０．１ｍｌ（２０７．２Ｂｑ／只），２ｍｉｎ后心肌摄取达峰值１７．７５±０．３３％（ｇ ｏｒｇａｎ）＾－１；心肌清除也快，１５ｍｉｎ已清除至     

Research progress of solid electrolytes

商业化的锂离子电池大多采用有机液体作为电解质体系,有机液体电解质在电池的工作过程中,会发生泄漏、挥发、燃烧甚至爆炸,存在严重的安全隐患,研究高效、环保、安全的电解质是解决这一问题的主要途径。固体电解质取代传统的液体电解质,不仅可以在传输导锂的同时抑制锂枝晶的生长,而且具有高的机械强度,简化电池的制备工艺,降低电池的制造成本。由于具有以上的优点,固体电解质的研发不断引起人们的广泛关注。本文综述了硫化物固体电解质的研究进展,包括二元和三元硫化物固体电解质,同时讨论了掺杂改性或复合改性对其性能影响,并展望了硫化物固体电解质未来的发展方向。     

自适应模糊算法在光伏系统MPPT中的应用

针对光伏电池的非线性特性,介绍了最大功率点跟踪的原理,并详细分析了常规控制算法在光伏系统最大功率跟踪控制中的优缺点,提出将自适应模糊控制算法应用到光伏系统最大功率点跟踪的控制中,自适应模糊控制能快速响应外界环境的变化,在最大功率点无明显振荡现象.实验结果表明,该方法能使系统稳定工作在最大功率点,同时能对外界环境的变化做出快速反应.     

Electrical Properties of Laser-Synthesized Aluminum Oxide-Tungsten Oxide Ceramics

Electronic ceramics of the Al₂O₃-WO₃ system were synthesized by using a high-powered CO₂ laser. It was shown that these ceramics can be used as linear thermistor materials. The linear temperature range of the Al₂O₃-WO₃ system was ~200°C, the nonlinear deviation epsilon was <2%, the thermistor constant B was <10³, and the temperature coefficient was between -0.2%/°C and -0.8%/°C. These parameters could be adjusted by changing the composition of the samples and the laser-synthesis parameters. The present study showed that the materials should be encapsulated if they are to be used in an oxidizing atmosphere. The current-voltage curves of the present materials were symmetrical around the coordinate origin, which also is a necessary condition for judging whether or not a thermistor is linear.     

Terminal Protection of Small Molecule-Linked DNA for Small Molecule–Protein Interaction Assays

Methods for the detection of specific interactions between diverse proteins and various small-molecule ligands are of significant importance in understanding the mechanisms of many critical physiological processes of organisms. The techniques also represent a major avenue to drug screening, molecular diagnostics, and public safety monitoring. Terminal protection assay of small molecule-linked DNA is a demonstrated novel methodology which has exhibited great potential for the development of simple, sensitive, specific and high-throughput methods for the detection of small molecule–protein interactions. Herein, we review the basic principle of terminal protection assay, the development of associated methods, and the signal amplification strategies adopted for performance improving in small molecule–protein interaction assay.     

一类分式规划的对偶定理

本文在预不变凸性条件下,利用有效解概念,结出一类分式线性规划的一些对偶定理,这些定理为求解这类分式线性规划提供了简捷方法。