pH‐Activated Near‐Infrared Fluorescence Nanoprobe Imaging Tumors by Sensing the Acidic Microenvironment

Imaging tumors in their early stages is crucial to increase the surviving rate of cancer patients. Currently most fluorescence probes visualize the neoplasia by targeting the tumor‐associated receptor over‐expressed on the cancer cell membrane. However, the expression level of these receptors in vivo is hard to predict, which limits their clinical translation. Furthermore, the signal output of these receptor‐targeting probes usually stays at a high level, which leads to a strong background signal in normal tissue due to non‐specific binding. In contrast to receptors, characteristics of the tumor microenvironment – such as acidosis – are pervasive in almost all solid tumors and can be easily accessed. In this work, a novel biodegradable nanoprobe InNP1 that demonstrates pH‐activated near‐infrared (NIR) fluorescence in both human glioblastoma U87MG cancer cells in vitro and the subcutaneous U87MG tumor xenografts in vivo is developed. Bio‐distribution, in vivo optical imaging, and autoradiography studies demonstrate that the pH‐activated NIR fluorescence is the dominant factor responsible for the high tumor/normal tissue (T/N) ratio of InNP1 in vivo. Overall, the work provides a nanoprobe prototype to visualize the solid tumor in vivo with high sensitivity and minimal systemic toxicity by sensing the tumor acidic microenvironment.     

高精度图像尺寸检测镜头畸变校正方法与实现

在高精度轴类零件尺寸图像检测中,提出了一种基于标准件法对镜头径向畸变进行快速校正的方法。该方法通过建立世界坐标转换到摄像机坐标、然后再转换到图像坐标的理想数学模型,并引入径向畸变参数,最终确立物体在世界坐标中与图像坐标中的映射关系,从而建立误差补偿曲线的高次拟合函数。利用得到的误差补偿函数的系数矩阵和径向畸变参数,实现镜头畸变的误差校正,有效改善了镜头畸变造成的检测误差。实验表明,该方法快速有效,提高了检测精度、降低了设备成本、检测精度可达2 μm。     

机载红外搜索跟踪系统（二）

红外搜索跟踪（ＩＲＳＴ）系统在军事和民用领域中有广泛应用。叙述了机载ＩＲＳＴ系统的作用，介绍两个机载ＩＲＳＴ系统的实例。     

A Class of Sequential Blind Source Separation Method in Order Using Swarm Optimization Algorithm

We consider the problem of sequential, blind source separation in some specific order from a mixture of sub- and sup-Gaussian sources. Three methods of separation are developed, specifically, kurtosis maximization using (a) particle swarm optimization, (b) differential evolution, and (c) artificial bee colony algorithm, all of which produce the separation in decreasing order of the absolute kurtosis based on the maximization of the kurtosis cost function. The validity of the methods was confirmed through simulation. Moreover, compared with other conventional methods, the proposed method separated the various sources with greater accuracy. Finally, we performed a real-world experiment to separate electroencephalogram (EEG) signals from a super-determined mixture with Gaussian noise. Whereas the conventional methods separate simultaneously EEG signals of interest along with noise, the result of this example shows the proposed methods recover from the outset solely those EEG signals of interest. This feature will be of benefit in many practical applications.     

单片机模糊PID自整定控制算法的实现及仿真

工业控制中常用的传统PID算法,其参数整定不仅复杂、费时、费力,而且不易取得最优参数,使控制过程达不到理想状态。针对此利用单片机的计算优势,融合最新的模糊控制理论,提出了一种新型的自动的PID参数整定方法,通过软件模拟及实际检验,均达到了理想效果。     

一种用于流水线ADC的高速电压比较器

文章介绍了一种高速电压差分比较器电路，该电路采用了两级运放结构。由前置预放大级和带复位端的闩锁输出级组成。该电路采用0．18μm工艺实现，对其进行了电路原理分析和HSHCE仿真。得到的仿真结果和波形说明该比较器具有速度快、精度高、功耗低的特点，适用于流水线结构的高速模数转换器。     

激光二极管双侧泵平板Nd:LuVO4晶体热效应

以解析热分析理论为基础,建立了平板Nd:LuVO4晶体在激光二极管阵列双侧泵抽运时的导热微分方程。通过方程求解,得到平板Nd:LuVO4晶体内部温度场分布的解析式及热形变分布。温度场和热形变场的数值模拟表明:当泵浦光平均功率Po=10 W、泵浦区域为1 mm×1 mm时,四组激光二极管阵列光源在三处不同位置的一维温度场、二维温度场分布和热形变量有很大差异;将三处泵浦光源位置所产生的温度分布和热形变量对比,得到了泵浦光源在位置1、2处所产生的温升和热形变量相对较小,位置3处最大。所得结论可为平板Nd:LuVO4激光器的设计及热效应消除提供理论依据。     

储能优化技术在太阳能路灯系统中的应用

将蓄电池飞轮储能模型应用于太阳能路灯系统中。该模型以成本最小化为目标,以系统的稳定性、实用性和低能耗为约束条件,分别采用线性规划和遗传算法对所建的数学模型进行优化计算。研究结果表明,2种优化方法均能找到稳定的最优解,且遗传算法优于线性规划算法。     

亚硫酸盐浆CEH漂白废水的特性及其光催化氧化处理

本文对蔗渣、竹子、芒杆混合亚硫酸盐浆ＣＥＨ 漂白废水的特性进行了较详细的分析研究。研究表明,该废水ＢＯＤ５／ＣＯＤ为０ ．１８３ ,Ｃｌ－ 含量高达１１５２ ．５ｍｇ／ｌ,不适合于传统的生物氧化法处理。废水中的大分子有机污染物是废水色度的主要来源,废水的色度和ｐＨ 值密切相关。采用ＵＶ／ＴｉＯ２ 光催化氧化工艺处理该废水的初步研究结果表明,在充分供氧的条件下,可使废水快速脱色,同时废水的ＣＯＤ指标大大下降。     

驻波透镜聚焦原子束制作纳米图形研究

介绍了将激光驻波聚焦原子束技术用于制作纳米级图形的基本原理和实验系统设计。研究了驻波透镜对原子束的聚焦特性及像差 ,数值结果显示原子束在置于焦平面处的基底上所沉积的条纹半高宽为 10nm左右 ,可以实现纳米级超微细图形的制作。同时给出了实验装置及初步实验结果