稠油降粘剂复配及降粘效果研究

研究了温度、单一降粘剂和复配降粘剂体系对河南某油田稠油的降粘效果,结果表明,稠油粘度随着温度上升而下降,当温度高于60℃时,粘度随温度升高下降缓慢并逐渐趋于稳定。等量等温试验条件下选取的5种降粘剂中AES的降粘效果最好,确定的降粘剂复配体系最佳复配条件为：AES用量0．2％,温度80℃,OP-10用量0．2％,十二烷基磺酸钠用量0．4％,此时降粘率达到97．50％以上。     

特柔软型钢丝铠装复合电缆设计探讨

本文主要探讨特柔软型钢丝铠装复合电缆的设计,根据特殊用户实际应用情况,设计出大拉力、超柔软钢丝铠装电缆,设计过程中不仅考虑电缆所应有的电性能,同时还要考虑电缆高强度抗张情况和应用中处于反复收放状态,而且所设计的电缆还要满足恶劣环境.     

基于期权的矿产资源采矿权估价单因素模型

矿产资源采矿权可以被认为是一个多期多阶段的复合看涨期权,在基于期权的采矿权价值形成机理研究基础上,假定无采矿权交易成本、不考虑关闭和开启矿山时的成本和矿山的永久性废弃以及利率为无风险利率,研究了矿产资源储量价值随机波动下的基于期权的矿产资源采矿权估价单因素模型,并结合一煤炭资源实例对比了收益现值法与单因素模型,发现期权估价方法较收益现值法能提高矿产资源采矿权价值。     

教育体验型文物建筑保护的可拓设计方法

研究了教育体验型文物建筑的保护设计中突出教育个性、保护教育形态和表达教育意蕴的可拓设计方法,对文物建筑保护设计具有本体论和方法论意义层面上的启示和借鉴作用,使文物建筑及其环境能更好地满足体验需求。     

电压比值差相位差对电能计量装置误差的影响

电压参数比值差、相位差是电能计量装置中引起电能计量误差的关键因素之一,通过电路分析和数学推导对电能计量相对误差εr与比值差f、相位差δ之间的关系进行分析.结果表明,f、δ是电压信号采集环节εr产生的直接原因;其中f与εr直接相关,δ通过tanφ与εr间接相关;f、δ、tanφ共同对εr数值产生影响.     

Optical coherent dot-product chip for sophisticated deep learning regression

Optical implementations of neural networks (ONNs) herald the next-generation high-speed and energy-efficient deep learning computing by harnessing the technical...     

Tuning the pinning direction of giant magnetoresistive sensor by post annealing process

The Internet of Things has created an increasing demand for giant magnetoresistive (GMR)sensor owing to its high sensitivity,low power-consumption and small siz...     

Antibody Therapies Targeting Complex Membrane Proteins

In analyses of protein families that may serve as drug targets, membrane-associated G-protein-coupled receptors (GPCRs) dominate, followed by ion channels, transporters, and—to a lesser extent—membrane-bound enzymes. However, various challenges put such membrane proteins among key groups of underutilized opportunities for the application of therapeutic antibodies. Antibodies hold the promise of exquisite specificity, as they are able to target even specific conformations of a particular membrane protein, as well as adaptability through engineering into various antibody formats. However, the ease of raising and isolating specific, effective antibodies targeting membrane proteins depends on many factors. In particular, the generation of specific antibodies is easier when targeting larger, simpler, extracellular domains with greater uniqueness of amino acid sequence. The rareness of such ideal conditions is illustrated by the limited number of approved biologics for targeting GPCRs and other complex membrane proteins. Challenges in developing antibodies to complex membrane proteins such as GPCRs, ion channels, transporters, and membrane-bound enzymes can be addressed by the design of the antigen, antibody-generation strategies, lead optimization technologies, and antibody modalities. A better understanding of the membrane proteins being targeted would facilitate mechanism-based drug discovery. This review describes the advantages and challenges of targeting complex membrane proteins with antibodies and discusses the preparation of membrane protein antigens and antibody generation, illustrated by select examples of success.     

Advances and Challenges in Two?Dimensional Organic–Inorganic Hybrid Perovskites Toward High?Performance Light?Emitting Diodes

Two-dimensional (2D) perovskites are known as one of the most promising luminescent materials due to their structural diversity and outstanding optoelectronic p...