基于支持向量回归的腔体滤波器机电耦合建模与优化

为了提高装配后的滤波器电性能和成品率,该文提出了一种基于支持向量回归的腔体滤波器机电耦合建模和优化方法。该方法根据工程中积累的经验数据,首先应用改进的多核线性规划支持向量回归算法建立了制造精度对滤波器电性能影响的机电耦合模型,然后应用此模型优化了滤波器的制造精度,从而获得了最优的机械结构尺寸。实际滤波器的实验结果验证了该方法的有效性。该方法可用于批量生产的腔体滤波器的计算机辅助制造系统中。     

中国科学院光电技术研究所的变形反射镜研究进展

变形反射镜是自适应光学系统的核心部件,也是开展自适应光学技术研究的首要研究对象。本文首先介绍了中国科学院光电技术研究所从事自适应光学特别是变形反射镜技术研究的历史背景,简述了光电所变形反射镜技术早期的发展脉络。然后介绍了光电所研制的变形反射镜在我国历代惯性约束聚变系统中的应用情况,也介绍了在天文光学观测领域典型的多单元变形镜技术及应用成果,随后还介绍了应用于生物医学等领域的紧凑型变形反射镜的发展情况和研究现状。最后介绍了光电所在变形反射镜技术新方向的研究情况。

     

“互联网+”时代师范院校教育教学改革的路径探讨

经济全球化和"互联网+"时代的到来,对师范院校教育教学带来了机遇与挑战。文章从师范院校的教学改革目标出发,提出了师范院校教育教学改革的主要方向,即倡导平等的生态和谐理念、构建人文精神的课程体系和完善精准高效的质量保障系统,并从调整教学重心、转变教师角色、完善课程体系、强化人文精神、改善教学环境和健全质量保障系统六个方面探讨了改革的路径,希望为师范院校的发展提供借鉴。     

Phellinus baumii Polyphenol: A Potential Therapeutic Candidate against Lung Cancer Cells

Phellinus baumii, a fungus that grows on mulberry trees and is used in traditional Chinese medicine, exerts therapeutic effects against various diseases, including cancer. Polyphenols, generally considered to be antioxidants, have antitumor and proapoptotic effects. In this study, we identified the composition of Phellinus baumii polyphenol (PBP) and characterized its 17 chemical components by UPLC–ESI–QTOF–MS. Furthermore, to clarify the potential mechanism of PBP against Lung Cancer Cells, network pharmacology and experimental verification were combined. Molecular docking elucidated the binding conformation and mechanism of the primary active components (Osmundacetone and hispidin) to the core targets CASP3, PARP1 and TP53. In addition, potential molecular mechanisms of PBP predicted by network pharmacology analysis were validated in vitro. PBP significantly inhibited the human lung cancer A549 cells and showed typical apoptotic characteristics, without significant cytotoxicity to normal human embryonic kidney (HEK293) cells. Analysis using flow cytometry and western blot indicated that PBP caused apoptosis, cell cycle arrest, reactive oxygen species (ROS) accumulation, and mitochondrial membrane potential (MMP) depression in A549 cells to exercise its antitumor effects. These results reveal that PBP has great potential for use as an active ingredient for antitumor therapy.     

熔渣中Zn、Pb挥发行为的对比分析

熔融工艺是目前处理工业粉尘及飞灰的有效方法.为了能够有效控制熔融工艺中Zn、Pb等重金属资源的分离回收,对比分析了Zn、Pb在含Cl的FeO-CaO-SiO₂-Al₂O₃-Fe₂O₃渣系中的挥发行为.首先通过热力学计算分析了Zn、Pb在该渣系中可能的挥发气体种类,以及各因子如温度、熔渣成分、氧势和Cl含量等的影响.同时,对以上问题进行了实验研究.最终明确了分别提高Zn、Pb挥发分离效率的不同的技术措施和优化参数.     

Photo-induced doping effect and dynamic process in monolayer MoSe2

Dynamic processes of electron transfer by optical doping in monolayer MoSe₂ at 6 K are investigated via measuring time resolved photoluminescence (PL) traces under different excitation powers. Time-dependent electron transfer process can be analyzed by a power-law distribution of t^−α with α = 0.1–0.24, depending on the laser excitation power. The average electron transfer time of approximately 27.65 s is obtained in the excitation power range of 0.5 to 100 μW. As the temperature increases from 20 to 44 K, the energy difference between the neutral and charged excitons is observed to decrease.     

Passively Mode Locked Diode-End-Pumped Yb∶YAB Laser with High Reflectivity Type Semiconductor Saturable Absorption Mirror

A novel high reflectivity type of semiconductor saturable absorption mirror grown by metal organic chemical vapor deposition is presented. Using the mirror as well as an end mirror,passively mode locked Yb∶YAB laser is realized,which produces a pulse as short as 305ps at 1.044μm.The pulse frequency is 375MHz;the output power is 45mW.     

基于聚类分析和主成分分析法的杨梅营养品质评价研究

采集温州7个地区不同东魁杨梅种植点的46个成熟杨梅样品,分析测定杨梅了10个营养参数,对所得结果进行因素聚类和主成分分析,得出了杨梅中10个营养参数之间的各自相关性,明确了影响杨梅品质的关键指标是草酸、葡萄糖和果糖组分,主成分的贡献比率分别为59.6%、23.5%和15.4%。基于糖酸比例得出了评价杨梅品质的5类品质特征。研究结果对快速评价杨梅品质优劣和指导杨梅种植具有帮助作用。      

合成酯型油性添加剂的研究

采用合成酯作为油性剂,与棕榈油进行了一系列的对比试验。结果表明,硬脂酸辛酯不仅在改善矿物油的润滑性及与硫、氯极压添加剂的复合效果方面与棕榈油相当,而且改善了抗氧化性,大幅度延长了油品的使用寿命,综合成本会显著下降。因此,硬脂酸辛酯可以代替棕榈油作油性剂使用。     

Incorporation of a FRET Pair into a Riboswitch RNA to Measure Mg2+ Concentration and RNA Conformational Change in Cell

Riboswitches are natural biosensors that can regulate gene expression by sensing small molecules. Knowledge of the structural dynamics of riboswitches is crucial to elucidate their regulatory mechanism and develop RNA biosensors. In this work, we incorporated the fluorophore, Cy3, and its quencher, TQ3, into a full-length adenine riboswitch RNA and its isolated aptamer domain to monitor the dynamics of the RNAs in vitro and in cell. The adenine riboswitch was sensitive to Mg²⁺ concentrations and could be used as a biosensor to measure cellular Mg²⁺ concentrations. Additionally, the TQ3/Cy3-labeled adenine riboswitch yielded a Mg²⁺ concentration that was similar to that measured using a commercial assay kit. Furthermore, the fluorescence response to the adenine of the TQ3/Cy3-labeled riboswitch RNA was applied to determine the proportions of multiple RNA conformational changes in cells. The strategy developed in this work can be used to probe the dynamics of other RNAs in cells and may facilitate the developments of RNA biosensors, drugs and engineering.