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Shock increases mortality from brain injuries, but the mechanism is poorly understood. We hypothesized that brain injury followed by shock and resuscitation leads to a secondary reperfusion injury mediated in part by polymorphonuclear leukocytes (PMNs). To validate this hypothesis, we studied cerebral perfusion pressure (CPP), intracranial pressure (ICP), cerebral blood flow (CBF), cortical water content (CWC), and hemodynamic variables in a porcine model of focal cryogenic brain injury and hemorrhagic shock. Cerebral PMN accumulation (CPMN) in the injured and uninjured hemispheres was determined histologically from the total PMNs in five high-power fields (400x). Twenty-nine mature swine were randomized to four groups. Group 1, the control group, was instrumented only. Group 2 animals had a brain injury alone and were studied for 24 hours. Group 3 animals had a brain injury and hemorrhagic shock. Group 4 animals had hemorrhagic shock alone. Brain injury followed by shock caused a significantly greater ICP and a significantly lower CBF than brain injury or shock alone. There was no significant difference in CPP between groups after resuscitation. The CWC of the lesioned area was similar in both brain-injured groups but was significantly increased when compared with the controls and the shock-only group. The CWC of the nonlesioned hemisphere was higher in group 3 than in group 2. The CPMN in both hemispheres in group 3 was significantly greater than in either group 2 or group 4. There was a significant positive correlation between CPMN and both ICP and CWC, and a significant negative correlation between CPMN and CBF. These data suggest an association between CPMN accumulation and secondary brain injury. 相似文献
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Aerodynamic loads on a multi-bladed helicopter rotor in hovering flight were calculated by solving the three-dimensional incompressible Navier-Stokes equations. The rotor wake effects were accounted by the correction of local geometric angle of attack according to a free-wake modeling in addition to an empirical modification for the tip flow effect. The validity and efficiency of the present method were verified by the comparisons between numerical results and experimental data. 相似文献
45.
协联运行曲线是双调机组自动运行时导叶与桨叶的关系曲线,它对机组安全稳定和经济运行起着重要的作用。通过实际运行发现,原协联曲线与实际运行工况存在较大差异,提出了对原协联曲线的修正意见和修正方法,并取得了良好的效果。 相似文献
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47.
X. Liang X. Wang J. Zhuang Y. Chen D. Wang Y. Li 《Advanced functional materials》2006,16(14):1805-1813
Uniform magnetite, hematite, and goethite nanocrystals were prepared through an attractive method based on an oleic acid/alcohol/water system. By adjusting the synthetic parameters (base concentration, alcohol content, categories of alcohols, etc.), the controlled synthesis of uniform magnetite, hematite, and goethite nanocrystals can be easily achieved. Detailed investigations on the effect of the experimental parameters on the morphology of the final products and the phase transitions among the magnetite, hematite, and goethite phases were carried out. Finally, a method of doping other metal ions into magnetite was developed and the magnetic properties of magnetite doped with different metal elements were studied. 相似文献
48.
对一系列低价态双核原子簇化合物的UV-Vis光谱进行了定性研究,尤其是λ>300nm处,发现过渡金属的d-d电子跃迁行为,并对个别化合物进行初步量子化学处理. 相似文献
49.
介绍了地层测试器密封设计中常用的材料、影响密封性能的主要因素;定性地论述了井下工具密封设计中应遵循的原则及注意事项。 相似文献
50.
高压氮气中自蔓延燃烧合成氮化钛 总被引:1,自引:0,他引:1
利用钛粉在高压氮气中的自蔓延燃烧合成(SHS),制备了含氮量较高的TiN,研究了反应物的松装密度、氮气压的改变与稀释剂的加入对燃烧波蔓延速率和产物转化率的影响,还观察到燃烧方式的改变。 相似文献