Service level agreement and provisioning in optical networks

This article proposes a service level agreement applied to the optical domain (O-SLA), which is expected to be the near- and long-term network technology of the great bandwidth capacity offered by optical devices. After an exposition of the rationale behind an optical SLA, parameters that could be included in this O-SLA, as well as their values for four classes of services are proposed. Different client (wavelength or subwavelength) and service types (from leased wavelength to bandwidth on demand) are distinguished when necessary. The last part of this article presents issues related to the provisioning of services emanating from this O-SLA.     

Iron catalyst for decomposition of methane: Influence of Al/Si ratio support

20% iron catalysts supported on combined alumina and silica through different proportions (Al₂O₃:SiO₂: 100:0.00, 90.0:10.0, 80.0:20.0 and 0.0:100.0) were tested for the catalytic decomposition of methane to produce H₂ and carbon. The catalysts were prepared via impregnation technique. The physicochemical properties of the catalysts were characterized with TGA, XRD, H2-TPR, and TEM techniques. The results specified no reaction for all temperatures when the catalysts were supported with bare silica. Indeed, the 20%Fe/(Si-80)-800 catalyst with 20% silica support operated at 800?°C produced CH₄ conversion profile that rapidly descended from 64% to 5% due to the high content of silica. Plain alumina supported catalyst demonstrated the best conversion and stability operated at 800?°C. The CH₄ conversion started from 83.4% and lasts at 82.2% after 300?min on stream.     

Priority-aware optical shared protection: An offline evaluation study

The availability of an optical connection is considered to be a critical service differentiator in WDM optical networks. In this regard, the design of a protection scheme that improves the availability of high priority optical connections and makes efficient use of optical resources is a major challenge faced by optical network operators. In a previous study, we proposed the so-called priority-aware shared protection survivability scheme as a potential solution to this design issue.In this paper, we complement our previous study. More specifically, we develop an offline study whose main purpose is to assess the efficiency of the priority-aware shared protection scheme. Through this study, we show that the priority-aware shared protection strategy as opposed to existing protection strategies is able to achieve the best tradeoff between optical resource usage and optical connections’ availability satisfaction.     

Characterization of electromagnetic fields close to microwave devices using electric dipole probes

A methodology to thoroughly characterize an electric near‐field probe based on small dipole antenna is presented. Both theoretical investigations and experimental direct measurements determine the various characteristics of the probe such as selectivity, sensitivity and spatial resolution. Results show the efficiency of the probe for diagnosing electromagnetic phenomena. © 2008 Wiley Periodicals, Inc. Int J RF and Microwave CAE, 2008.     

Heuristics for a two-stage assembly flowshop with bicriteria of maximum lateness and makespan

We consider a two-stage assembly flowshop scheduling problem with the objective of minimizing a weighted sum of makespan and maximum lateness. The problem is known to be NP-hard, and therefore, we propose heuristics to solve the problem. The proposed heuristics are Tabu search (Tabu), particle swarm optimization (PSO), and self-adaptive differential evolution (SDE). An extensive computational experiment is conducted to compare performances of the proposed heuristics. The computational experiment reveals that both PSO and SDE are much superior to Tabu. Moreover, it is statistically shown that PSO performs better than SDE. The computation times of both PSO and SDE are close to each other and they are less than 40 and 45 s, respectively, for the largest size problem considered.     

Hybrid evolutionary algorithm and application to structural optimization

This paper introduces a new evolutionary algorithm with a globally stochastic but locally heuristic search strategy. It is implemented by incorporating a modified micro-genetic algorithm with two local optimization operators. Performance tests using two benchmarking functions demonstrate that the new algorithm has excellent convergence performance when applied to multimodal optimization problems. The number of objective function evaluations required to obtain global optima is only 3.5–3.7% of that of using the conventional micro-genetic algorithm. The new algorithm is used to optimize the design of an 18-bar truss, with the aim of minimizing its weight while meeting the stress, section area, and geometry constraints. The corresponding optimal design is obtained with considerably fewer computational operations than required for the existing algorithms.     

High-Accuracy Relative Biological Effectiveness Values Following Low-Dose Thermal Neutron Exposures Support Bimodal Quality Factor Response with Neutron Energy

Theoretical evaluations indicate the radiation weighting factor for thermal neutrons differs from the current International Commission on Radiological Protection (ICRP) recommended value of 2.5, which has radiation protection implications for high-energy radiotherapy, inside spacecraft, on the lunar or Martian surface, and in nuclear reactor workplaces. We examined the relative biological effectiveness (RBE) of DNA damage generated by thermal neutrons compared to gamma radiation. Whole blood was irradiated by 64 meV thermal neutrons from the National Research Universal reactor. DNA damage and erroneous DNA double-strand break repair was evaluated by dicentric chromosome assay (DCA) and cytokinesis-block micronucleus (CBMN) assay with low doses ranging 6–85 mGy. Linear dose responses were observed. Significant DNA aberration clustering was found indicative of high ionizing density radiation. When the dose contribution of both the ¹⁴N(n,p)¹⁴C and ¹H(n,γ)²H capture reactions were considered, the DCA and the CBMN assays generated similar maximum RBE values of 11.3 ± 1.6 and 9.0 ± 1.1, respectively. Consequently, thermal neutron RBE is approximately four times higher than the current ICRP radiation weighting factor value of 2.5. This lends support to bimodal peaks in the quality factor for RBE neutron energy response, underlining the importance of radiological protection against thermal neutron exposures.     

Punicalagin Protects against the Development of Methotrexate-Induced Hepatotoxicity in Mice via Activating Nrf2 Signaling and Decreasing Oxidative Stress,Inflammation, and Cell Death

Despite its effectiveness in treating inflammatory diseases and various malignancies, methotrexate (MTX) is well known to cause hepatotoxicity, which involves increased oxidative stress and inflammation, limiting its clinical use. Herein, we looked into the effect of punicalagin (PU), a polyphenolic molecule having a variety of health-promoting attributes, on MTX-induced hepatotoxicity in mice. PU (25 and 50 mg/kg/day) was given orally to the mice for 10 days, while a single dose of MTX (20 mg/kg) was injected intraperitoneally (i.p.) at day 7. The MTX-induced liver damage was demonstrated by remarkably higher transaminases (ALT and AST), ALP, and LDH, as well as significant histological alterations in hepatic tissues. MTX-injected mice also demonstrated increases in hepatic oxidative stress markers, including malondialdehyde (MDA) and nitric oxide (NO), with a concordant drop in glutathione (GSH) content and superoxide dismutase (SOD) and catalase (CAT) activities. PU significantly attenuated the MTX-induced serum transaminases, ALP and LDH elevations, and hepatic oxidative stress measures and boosted antioxidant defenses in the liver. Moreover, the liver of MTX-treated mice showed increases in NF-κB p65 expression, pro-inflammatory cytokine (IL-6 and TNF-α) levels, and pro-apoptotic protein (caspase-3 and Bax) expression, whereas Bcl-2 and Nrf2 expressions were reduced, which were all attenuated by PU treatment. Collectively, PU inhibits oxidative damage, inflammation, and apoptosis and upregulates Nrf2 in the liver of MTX-induced mice. Thus, these findings suggest that PU may have great therapeutic potential for the prevention of MTX-induced hepatotoxicity, pending further exploration in upcoming studies.     

Antithrombotic Effects of Fostamatinib in Combination with Conventional Antiplatelet Drugs

New antithrombotic medications with less effect on haemostasis are needed for the long-term treatment of acute coronary syndromes (ACS). The platelet receptor glycoprotein VI (GPVI) is critical in atherothrombosis, mediating platelet activation at atherosclerotic plaque. The inhibition of spleen tyrosine kinase (Syk) has been shown to block GPVI-mediated platelet function. The aim of our study was to investigate if the Syk inhibitor fostamatinib could be repurposed as an antiplatelet drug, either alone or in combination with conventional antiplatelet therapy. The effect of the active metabolite of fostamatinib (R406) was assessed on platelet activation and function induced by atherosclerotic plaque and a range of agonists in the presence and absence of the commonly used antiplatelet agents aspirin and ticagrelor. The effects were determined ex vivo using blood from healthy volunteers and aspirin- and ticagrelor-treated patients with ACS. Fostamatinib was also assessed in murine models of thrombosis. R406 mildly inhibited platelet responses induced by atherosclerotic plaque homogenate, likely due to GPVI inhibition. The anti-GPVI effects of R406 were amplified by the commonly-used antiplatelet medications aspirin and ticagrelor; however, the effects of R406 were concentration-dependent and diminished in the presence of plasma proteins, which may explain why fostamatinib did not significantly inhibit thrombosis in murine models. For the first time, we demonstrate that the Syk inhibitor R406 provides mild inhibition of platelet responses induced by atherosclerotic plaque and that this is mildly amplified by aspirin and ticagrelor.