Resveratrol Butyrate Esters Inhibit BPA-Induced Liver Damage in Male Offspring Rats by Modulating Antioxidant Capacity and Gut Microbiota

Resveratrol can affect the physiology or biochemistry of offspring in the maternal–fetal animal model. However, it exhibits low bioavailability in humans and animals. Fifteen-week SD pregnant female rats were orally administered bisphenol A (BPA) and/or resveratrol butyrate ester (RBE), and the male offspring rats (n = 4–8 per group) were evaluated. The results show that RBE treatment (BPA + R30) compared with the BPA group can reduce the damage caused by BPA (p < 0.05). RBE enhanced the expression of selected genes and induced extramedullary hematopoiesis and mononuclear cell infiltration. RBE increased the abundance of S24-7 and Adlercreutzia in the intestines of the male offspring rats, as well as the concentrations of short-chain fatty acids (SCFAs) in the feces. RBE also increased the antioxidant capacity of the liver by inducing Nrf2, promoting the expression of HO-1, SOD, and CAT. It also increased the concentration of intestinal SCFAs, enhancing the barrier formed by intestinal cells, thereby preventing BPA-induced metabolic disruption in the male offspring rats, and reduced liver inflammation. This study identified a potential mechanism underlying the protective effects of RBE against the liver damage caused by BPA exposure during the peri-pregnancy period, and the influence of the gut microbiota on the gut–liver axis in the offspring.     

On the study of creep feed grinding of alumina

Several issues involved in creep feed grinding of alumina with diamond wheels were studied. Influences of variables on responses were investigated. Off-line optimization was performed by formulating the grinding process as a multi-objective nonlinear mixed integer problem. The dominant mechanism of material removal was determined. The grinding process was simulated to obtain the number of active cutting edges and the grinding parameters such as cutting length, maximum undeformed chip thickness, etc. Unit load distribution was characterized and then used to estimate the percentage of cutting edges that fracture or plastically cut the material and to derive the probability distribution function for substance cracks. Fractal concept was applied to characterize wheel profiles. Findings from these studies are reported in this paper. These studies are definitely not complete, but surely shed some light on the creep feed grinding process of ceramic materials.     

AN INVESTIGATION OF QUASI-CLEAVAGE FRACTURE IN STEEL

本文试图探讨准解理断裂的本质。联系多晶材料的典型应力一应变曲线,对不同钢的断裂韧度试样的断口分析表明,准解理断裂可以看作是一种过渡的断裂机制。首先,一系列微观解理裂纹在高拉伸应力集中地方生核,然后这些裂纹各自沿着它本身已变形晶粒的解理面上扩展,最后借助于微观塑性聚合方式,这些微裂纹彼此连接。根据上述断裂模型可以认为:解理裂纹与塑性变形间的相互作用是准解理断裂的一种重要性质。借助于断口定量分析方法,有可能把断口形貌和一些力学参数间关系建立起来。     

Employing fractals and FEM for detailed variation analysis of non-rigid assemblies

Many studies on non-rigid assemblies, or assemblies of non-rigid components, suggest that the component variation affects the assembly dimensional quality. However, little is known about how the variation of surface micro-geometry of assembly components influences the assembly dimensional quality. In this paper, a new method based on the fractal geometry and finite element method (FEM) is proposed to study such an influence. In the new method, a special fractal function, named the Weierstrass–Mandelbrot (W–M) function, is used to extract and represent the characteristics of surface micro-geometry of assembly components. FEM is applied to analyze the deformation of non-rigid assemblies by integrating the variation of component micro-geometry. The sensitivity matrix between the component variation and assembly variation is obtained by using the existing influence coefficients method. It is found that contributions of the surface micro-geometry of assembly components to the final variation of non-rigid assemblies could be substantial under certain conditions. The proposed method is illustrated through a case study on an assembly of two flat sheet metal components under different fixture-releasing conditions.     

液相还原法制备纳米银粉的研究

在液相联氨还原法工艺基础上，对液相还原法制备纳米银粉的还原反应条件（体系温度、分散剂、反应物浓度）进行了研究，得到了优化的反应条件；反应体系温度70℃，反应物浓度[Ag[NH3]2^ ]=0.02mol/l和特定的分散剂2^#。且冬季同平均粒径约为50nm、大小均匀、灰白色的球状银粉。     

碳化硅晶须双重加热合成的研究

双重加热法是低成本、大批量合成碳化硅晶须的新技术，合成温度低、合成时间短、生成率高。对以炭黑和二氧化硅微粉为原料、用双重加热法合成碳化硅晶须的工艺过程进行了研究。观察了不同合成时间、合成温度和催化剂条件下的碳化硅晶须，揭示出不同工艺参数对合成的碳化硅晶须的产出率，微观形貌、直径和长度范围的影响。结果表明，催化剂的使用可以加快反应速度，提高碳化硅晶须的生成率，合成过程为VLS。实验中初步得到的最佳经济工艺参数为：Fe2O3的用量为2％，合成时间为1．5h，合成温度为1250℃。此时的该工艺条件下碳化硅晶须的生成率可达80％，晶须平均直径为0．6μm，平均长度为30μm。     

山梨酸正丁酯的合成研究

以山梨酸与正丁醇为原料,对甲苯磺酸为催化剂合成了山梨酸正丁酯,用乙酸丁酯作带水剂,4A分子筛作除水剂,酯化收率可达97.5%.     

Preparation of fluoroacrylate nanocopolymer by miniemulsion polymerization used in textile finishing

Latex based on fluoroacrylate (TAN) and other comonomers was prepared via miniemulsion polymerization in the presence of stearyl trimethyl ammonium chloride (STAC) and 2, 2′‐azobis (2‐amidinopropane) dihydrochloride (ABAP) as a water soluble initiator. Light transmittance studies demonstrated that the light transmittance of prepared emulsions increases with the amount of TAN, STAC, cosolvent DPM, and hydrophobe DM. Given suitable reaction temperature and quantities of TAN, STAC, DPM, and DM, a copolymer emulsion of fluoroacylate with a particle size of 50 nm was produced. The water repellency tested on polyester fabrics displayed greater effectiveness than that of commercial products with higher fluorine content. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 94: 1466–1472, 2004     

高性能环氧树脂涂料的研制

以甲基丙烯酸、丙烯酸丁酯及苯乙烯的聚合为接枝体，在过氧化苯甲酰作用下对E-51环氧树脂进行接枝改性，同时对三乙烯四胺进行曼尼希改性，制得多种改性固化剂，并用其与改性的环氧树脂配制成涂料，实验结果表明，当苯酚、甲醛和三乙烯四胺的物质的量比为3：3：1时固化剂的固化性能最好。     

改进马蹄焰玻璃窑炉加料口设计的体会

我厂总结加料实际运行情况,分析加料口对配合料熔化作业的影响,在仍采用一台(嘴宽为800mm)毯式推料加料机情况下,对24m~2的马蹄焰熔炉加料口结构进行了改进,取得了较好的效果。