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61.
Stainless steel ground anchors are still rarely used in Europe. A project was initiated to demonstrate the technical and economic performance of stainless steels for such applications. Three different steel grades were examined, i.e. two austenitic grades 1.4311 (‘304LN’) and 1.4406 (‘316LN’) and one duplex grade 1.4362 (‘2304N’). All of them had low carbon contents (< 0.03%) and were alloyed with nitrogen to improve their strength properties. Different electrochemical tests were carried out to assess the performance of stainless steel in chloride/sulphate environments. The results confirmed that the investigated stainless steels may be employed for a wide range of corrosive ground anchor environments.  相似文献   
62.
    
Extracellular vesicles (EVs) are widely used as natural nanoparticles to deliver various cargos for disease diagnosis and therapy. However, unmodified EVs cannot efficiently transport the cargos to desired sites due to non-specific uptake. Here, a delivery system is designed to display nanobodies against cadherin 17 (CDH17) on the surface of EVs isolated from HEK-293 cells and loaded with dye Indocyanine green (ICG) and/or anti-cancer drug dinitroazetidine derivative RRx-001, a blocker for CD47/ signal regulatory protein alpha (SIRPα) axis. CDH17 is a promising target for gastric cancer (GC) therapy. In this study, ICG loaded in the EVs engineered with CDH17 nanobodies can realize rapid tumor imaging in a CDH17-positive GC model and can produce significant anti-tumor photothermal therapeutic (PTT) effect after irradiation. Meanwhile, PTT effect can induce immunogenic cell death and macrophage polarization from M2 to M1 phenotype. The engineered EVs loaded with RRx-001 can significantly repress GC tumor growth. Finally, dual loading of ICG/RRx-001 in engineered EVs show maximal anti-tumor efficacy in both cancer cell and patient-derived GC models after only single injection. Collectively, CDH17 nanobody-functionalized EVs loaded with ICG and/or RRx-001 hold great promise to image and treat GC by combining fluorescent dye-induced PTT with chemotherapy.  相似文献   
63.
The requirements for drying and thermobonding equipment working on the basis of the hot air flow-through system vary considerably due to the large variety of nonwovens qualities, production methods and required production speeds. It is therefore necessary to construct diverse drying systems in order to be able to offer appropriate machines for the desired purposes. Optimum heat and mass transfer from the penetrating air to the permeable material to be dried is ensured by through-air drying

Following Hans Fleissner's invention of the through-air system for drying of textiles and its practical application in the perforated drum dryer for more than 50 years a second engineering breakthrough for the paper and nonwovens industry has been achieved by Gerold Fleissner with the high-tech through-air drum

This paper presents various possibilities of air flow through the material and provide criteria to facilitate selection of the proper drying system  相似文献   
64.
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