Phosphofructokinase from mantle tissue of Mytilus galloprovincialis. Purification and effects of phosphorylation on the enzymatic activity

Phosphofructokinase purified from mantle tissue of the sea mussel Mytilus galloprovincialis, was phosphorylated "in vitro" by the catalytic subunit of cyclic AMP-dependent protein kinase. The incorporation of phosphate gave rise to an activation of the enzyme by increasing its affinity for fructose-6-phosphate, by decreasing its sensitivity to the inhibition by ATP and by enhancing the effect of allosteric activators (5'-AMP and fructose-2,6-bisphosphate). In addition, the effects of phosphorylation on the catalytic activity are pH-dependent.     

Design and implementation of efficient QCA full-adders using fault-tolerant majority gates

The Journal of Supercomputing - CMOS technology is facing physical limitations in scaling the manufacturing process. Therefore, to deepen the development of better designs in a smaller area, it is...     

Models of Ballistic Propagation of Heat at Low Temperatures

Heat conduction at low temperatures shows several effects that cannot be described by the Fourier law. In this paper, the performance of various theories is compared in case of wave-like and ballistic propagation of heat pulses in NaF.     

Covariance of the absorption of phytoplankton, colored dissolved organic matter, and detritus in case I waters, as deduced from the Coastal Zone Color Scanner bio-optical algorithm

The universal bio-optical algorithm of the Coastal Zone Color Scanner (CZCS) for case I waters implicitly contains an average covariance of the absorption by phytoplankton and colored dissolved organic matter (CDOM) and detritus. We made that covariance explicit by combining the CZCS algorithm with an expression for reflectance. The spectral variation of absorption by CDOM plus detritus for case I waters may be estimated by the expression a(gd(λ)) = 2a(ph)(443)*chl{exp[-0.013(λ - 443)].     

Excess volumes and excess viscosities of binary mixtures of some cyclic ethers + bromocyclohexane at 298.15 and 313.15 K

Excess Volumes,V ^E, and excess viscosities, ^E, at 293.15 and 313.15 K are reported for binary mixtures of some cyclic ethers (tetrahydrofuran, tetrahydropyran, 2-methyltetrahydrofuran and 2,5-dimethyltetrahydrofuran) + bromocyclohexane. These properties were obtained from density and viscosity measurements. ^E and ^E show negatives values for all the mixtures.     

The urologic work of Doctor Alejandro Settier (1858-1915). (V). Specialist Alejandro Settier

In spite of the names and works of practically all the early 19th Century Spanish specialists in urinary tract being widely known, there are still in my opinion several names and writings, either forgotten or misplaced in newspaper libraries, archives and general libraries, awaiting to be discovered. The second half of the 19th Century was a prolific age in every aspect of Spanish life, most particularly literature. In Medicine, apart from the well known professional writings, the number of scientific journals and publications, whether in the form of brochures or divulgative articles, that came to light was countless. Computer management of collections currently under implementation in many registers, will allow their location and the finding of new texts. One of these long forgotten pioneers, is Doctor Alejandro Settier (1858-1915), a Valencian practitioner who describes himself as a "disciple of the Paris hospitals and specialist in genitourinary tract disorders", who practised in Madrid between 1883 and 1890. Surprisingly, and in spite of him being the most prolific author in urological issues during the last century (my investigations show he is the author of 2 books, 3 brochures and 40 articles in journals), neither his name nor his work, as far as we know, are mentioned by none of the historians consulted, which is nothing but highly surprising if we also take into consideration that Alejandro Settier was the founder of the first Spanish monographic journal for urinary disorders: "Gaceta de enfermedades de los órganos génito-urinarios" (Gazette of genitourinary organs disorders), Madrid 1887, which in spite of its short existence, can be considered as the first scientific periodical publication in our specialty.     

Diseases of the digestive system and a system for patient classification: diagnostic-related groups (DRG)

In the last years different classification systems for hospitalized patients have been developed in the United States, that allow to evaluate different aspects of any Hospital: The quality, the efficacy and the efficiency. The classification of "The Diagnosis Related Groups" (DRG) relates the hospitalized patients with the expenses that they generate, and it is the most used in Europe. In the version DRG-All Patient, all the diagnoses and procedures of the hospitalized patients, using the International Classification of Diseases, are divided in to 25 Major Diagnostic Categories (MDC) where each one excludes all the others. We describe the behavior with respect to the age, sex and stay of all the GDR integrated in the CDM 6 and 7: diseases and disorders of the digestive tract, and diseases and disorders of the hepatobiliary system and the pancreas. The study has been carried out with a national data base of two millions of cases seen from 214 acute-care Hospitals. The MDC number 6 is the most frequent, with an important number of patients in the pediatric age; it is more frequent in males; the average stay is 8.59 days and 19 GDR (36.5%) have a variation coefficient greater than one. The other MDC, number 7 is less frequent, the majority of the patients are between 60-80 years of age, the average stay is 12.2 days with a coefficient of variation greater than one in 4 GDR (17.4%). Clinical Services should know the characteristics and behavior of their patients, as well as the comparison with the national data bases. This may allow a control of the quality and the costs by using a common "language" with the managers.     

An improved method for voice pathology detection by means of a HMM-based feature space transformation

This paper presents new a feature transformation technique applied to improve the screening accuracy for the automatic detection of pathological voices. The statistical transformation is based on Hidden Markov Models, obtaining a transformation and classification stage simultaneously and adjusting the parameters of the model with a criterion that minimizes the classification error. The original feature vectors are built up using classic short-term noise parameters and mel-frequency cepstral coefficients. With respect to conventional approaches found in the literature of automatic detection of pathological voices, the proposed feature space transformation technique demonstrates a significant improvement of the performance with no addition of new features to the original input space. In view of the results, it is expected that this technique could provide good results in other areas such as speaker verification and/or identification.