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排序方式: 共有2182条查询结果,搜索用时 15 毫秒
51.
Henan Guo Yucui Tong Junhao Cheng Zaheer Abbas Zhongxuan Li Junyong Wang Yichen Zhou Dayong Si Rijun Zhang 《International journal of molecular sciences》2022,23(3)
Recently, the drawbacks arising from the overuse of antibiotics have drawn growing public attention. Among them, drug-resistance (DR) and even multidrug-resistance (MDR) pose significant challenges in clinical practice. As a representative of a DR or MDR pathogen, Staphylococcus aureus can cause diversity of infections related to different organs, and can survive or adapt to the diverse hostile environments by switching into other phenotypes, including biofilm and small colony variants (SCVs), with altered physiologic or metabolic characteristics. In this review, we briefly describe the development of the DR/MDR as well as the classical mechanisms (accumulation of the resistant genes). Moreover, we use multidimensional scaling analysis to evaluate the MDR relevant hotspots in the recent published reports. Furthermore, we mainly focus on the possible non-classical resistance mechanisms triggered by the two important alternative phenotypes of the S. aureus, biofilm and SCVs, which are fundamentally caused by the different global regulation of the S. aureus population, such as the main quorum-sensing (QS) and agr system and its coordinated regulated factors, such as the SarA family proteins and the alternative sigma factor σB (SigB). Both the biofilm and the SCVs are able to escape from the host immune response, and resist the therapeutic effects of antibiotics through the physical or the biological barriers, and become less sensitive to some antibiotics by the dormant state with the limited metabolisms. 相似文献
52.
Sadaqat Ali Bilal Anjum Ahmed Hafiz Muzammil Irshad Akolade Idris Bakare Abbas Saeed Hakeem Muhammad Qamaruddin Muhammad Ali Ehsan Sameer Ali Muhammad Umar Azam 《International Journal of Applied Ceramic Technology》2020,17(4):1948-1958
The thermomechanical behavior of micro/nano-alumina (Al2O3) ceramics reinforced with 1-5 wt.% of acid-treated oil fly ash (OFA) was investigated. Composites were sintered using spark plasma sintering (SPS) technique at a temperature of 1400°C by applying a constant uniaxial pressure of 50 MPa. It was evaluated that the fracture toughness of micro- and nanosized composites improved in contrast with the monolithic alumina. Highest fracture toughness value of 4.85 MPam1/2 was measured for the nanosized composite reinforced with 5 wt.% OFA. The thermal conductivity of the composites (nano-/microsized) decreased with the increase in temperature. However, the addition of OFA (1-5 wt.%) in nanosized alumina enhanced the thermal conductivity at an evaluated temperature. Furthermore, a minimum thermal expansion value of 6.17 ppm*K−1 was measured for nanosized Al2O3/5 wt.% OFA composite. Microstructural characterization of Al2O3-OFA composites was done by x-ray diffraction and Raman spectroscopy. Oil fly ash particles were seen to be well dispersed within the alumina matrix. Moreover, the comparative analysis of the nano-/microsized Al2O3/OFA composites shows that the mechanical and thermal properties were improved in nanosized alumina composites. 相似文献
53.
Synthesis of Architectural-Cubic Porous Silicon by Electroless Stain Etching in V2O5 and HF Solution
Silicon - Porous silicon (PSi) samples were prepared via electroless stain etching of silicon substrates in HF using V2O5 as an oxidant and ethanol as a surfactant for different etching times. The... 相似文献
54.
M. Abbas Ali Ayesha Nargis Noor Hidayu Othman Ahmadil Fitri Noor Golam Sadik Jewel Hossen 《International Journal of Food Properties》2017,20(11):2569-2580
The oxidative stability and compositional characteristics of the pumpkin seed oil (PSO) exposed to microwaves were studied during heating at 170°C. The oxidative indices such as free fatty acid (FFA), peroxide value (PV), p-anisidine value (p-AV), TOTOX, specific extinctions and thiobarbituric acid (TBA) value of oils were significantly increased, and the increments were found to be significantly higher (P < 0.05) in unroasted seed oil as compared to roasted seed oil. The relative contents of polyunsaturated fatty acids (PUFAs) were decreased to 84.7%, and saturated fatty acids (SFAs) were increased to 119.5% in unroasted sample, after 9 h of heating. On the other hand, in 12 min roasted samples, the relative contents of PUFAs were decreased to 97.0%, and SFAs were increased to 102.6% after 9 h of heating. The triacylglycerol species LLL and OLL levels were decreased as a consequence of increased heating time, and the reduction tended to be significantly higher in unroasted samples as compared to roasted ones. The oxidation products formed were also investigated by FTIR. The present results indicated that microwave roasting of pumpkin seeds markedly enhanced the oxidative stability of the oils during heating. 相似文献
55.
A Modified Method for the Determination of N‐Nitrosodiethanolamine in Coconut Diethanolamide Using HPLC with Dual‐Wavelength UV–Vis Detector 下载免费PDF全文
Ramin Mostafalu Abbas Banaei Mohammad Hadi Riazi Fatemeh Ghorbani 《Journal of surfactants and detergents》2016,19(2):431-435
A simple and novel method based on high‐performance liquid chromatography with dual‐wavelength ultraviolet detection at 234 and 254 nm has been developed for the determination of underivatized N‐nitrosodiethanolamine in coconut diethanolamide. The correlation coefficient obtained shows that the method is correct. 相似文献
56.
Correct Prediction of the Vibration Behavior of a High Power Ultrasonic Transducer by FEM Simulation
Amir Abdullah Abbas Pak 《The International Journal of Advanced Manufacturing Technology》2008,39(1-2):21-28
This paper presents a study on three types of finite element analyses of high power ultrasonic transducer by using the finite element commercial software called ANSYS. The transducer geometry was treated as a 2D axi- symmetric model, 3D quart and full 3D model. For all of the simulations the modeled transducer was used in modal analysis and harmonic solutions to understand its mechanical behavior and its natural frequency. A comparison was made between each type of modeling and experimental results. This comparison allows the parameters of FEM models to be iteratively adjusted and optimized and also leads to selection of the best modeling type. The achieved FEM results exhibited a remarkably high predictive potential of ANSYS in modeling and simulation and allowed control on the design and on the vibration behavior of the high power ultrasonic transducer. 相似文献
57.
Reservoir operation rules are intended to help an operator so that water releases and storage capacities are in the best interests
of the system objectives. In multi-reservoir systems, a large number of feasible operation policies may exist. System engineering
and optimization techniques can assist in identifying the most desirable of those feasible operation policies. This paper
presents and tests a set of operation rules for a multi-reservoir system, employing a multi-swarm version of particle swarm
optimization (MSPSO) in connection with the well-known HEC-ResPRM simulation model in a parameterization–simulation–optimization
(parameterization SO) approach. To improve the performance of the standard particle swarm optimization algorithm, this paper
incorporates a new strategic mechanism called multi-swarm into the algorithm. Parameters of the rule are estimated by employing a parameterization–simulation–optimization approach,
in which a full-scale simulation model evaluates the objective function value for each trial set of parameter values proposed
with an efficient version of the particle swarm optimization algorithm. The usefulness of the MSPSO in developing reservoir
operation policies is examined by using the existing three-reservoir system of Mica, Libby, and Grand Coulee as part of the
Columbia River Basin development. Results of the rule-based reservoir operation are compared with those of HEC-ResPRM. It
is shown that the real-time operation of the three reservoir system with the proposed approach may significantly outperform
the common implicit stochastic optimization approach. 相似文献
58.
Sobia Noreen Sara Hasan Shazia Akram Ghumman Syed Nasir Abbas Bukhari Bushra Ijaz Huma Hameed Huma Iqbal Afeefa Aslam Mervat Abdelaziz Mohamed Elsherif Shazia Noureen Hasan Ejaz 《International journal of molecular sciences》2022,23(5)
The rapid progression in biomaterial nanotechnology apprehends the potential of non-toxic and potent polysaccharide delivery modules to overcome oral chemotherapeutic challenges. The present study is aimed to design, fabricate and characterize polysaccharide nanoparticles for methotrexate (MTX) delivery. The nanoparticles (NPs) were prepared by Abelmoschus esculentus mucilage (AEM) and chitosan (CS) by the modified coacervation method, followed by ultra-sonification. The NPs showed much better pharmaceutical properties with a spherical shape and smooth surface of 213.4–254.2 nm with PDI ranging between 0.279–0.485 size with entrapment efficiency varying from 42.08 ± 1.2 to 72.23 ± 2.0. The results revealed NPs to possess positive zeta potential and a low polydispersity index (PDI). The in-vitro drug release showed a sustained release of the drug up to 32 h with pH-dependence. Blank AEM -CS NPs showed no in-vivo toxicity for a time duration of 14 days, accompanied by high cytotoxic effects of optimized MTX loaded NPs against MCF-7 and MD-MBA231 cells by MTT assay. In conclusion, the findings advocated the therapeutic potential of AEM/CS NPs as an efficacious tool, offering a new perspective for pH-responsive routing of anticancer drugs with tumor cells as a target. 相似文献
59.
In the present work, performance of new configuration of Micro-gas turbine cogeneration and tri-generation systems, with a steam ejector refrigeration system and Heat recovery Steam Generator (HRSG) are studied. A micro-gas turbine cycle produces 200 KW power and exhaust gases of this micro-gas turbine are recovered in an HRSG. The main part of saturated steam in HRSG is used through a steam ejector refrigeration system to produce cooling in summer. In winter, this part of saturated steam is used to produce heating. In the first part of this paper, performance evaluation of this system with respect to Energy Utilization Factor (EUF), Fuel Energy Saving Ratio (FESR), thermal efficiency, pinch point temperature difference, net power to evaporator cooling load and power to heat ratio is carried out. It has been shown that by using the present cogeneration system, one can save fuel consumption from about 23% in summer up to 33% in winter in comparison with separate generation of heating, cooling and electricity. 相似文献
60.
Mohammed Sid Ahmed Houari Samir Benyoucef Ismail Mechab El Abbas Adda Bedia 《热应力杂志》2013,36(4):315-334
The thermoelastic bending analysis of functionally graded sandwich plates using the two-variable refined plate theory is presented in this paper. Unlike any other theory, the number of unknown functions involved is only four, as against five in case of other shear deformation theories. The theory presented is variationally consistent, has strong similarity with classical plate theory in many aspects, does not require shear correction factor, and gives rise to transverse shear stress variation such that the transverse shear stresses vary parabolically across the thickness satisfying shear stress free surface conditions. The sandwich plate faces are assumed to have isotropic, two-constituent material distribution through the thickness, and the modulus of elasticity, Poisson's ratio of the faces, and thermal expansion coefficients are assumed to vary according to a power law distribution in terms of the volume fractions of the constituents. The core layer is still homogeneous and made of an isotropic ceramic material. Several kinds of sandwich plates are used taking into account the symmetry of the plate and the thickness of each layer. The influences played by the transverse shear deformation, thermal load, plate aspect ratio, and volume fraction distribution are studied. Numerical results for deflections and stresses of functionally graded metal–ceramic plates are investigated. It can be concluded that the proposed theory is accurate and simple in solving the thermoelastic bending behavior of functionally graded plates. 相似文献