A randomised controlled trial of a low-molecular-weight heparin (Enoxaparin) to prevent deep-vein thrombosis in patients undergoing vascular surgery

The incidence of postoperative deep vein thrombosis (PDVT) after aortic surgery and lower limb revascularisation has not been assessed by a large prospective study. In a prospective randomised trial the effect of a low-molecular-weight heparin fragment, Enoxaparin (ENX) 4200 anti factor Xa IU once daily was compared to that of unfractionated heparin (UFH) 7500 IU twice daily. Two hundred and thirty-three consecutive patients were classified into three groups, aortic or aortoiliac and aneurysmectomy (n = 75), aorto-femoral bypass for atherosclerotic disease (n = 71), and femoropopliteal or femorodistal bypass (n = 87). Patients were analysed for development of deep vein thrombosis by Duplex scanning and, if positive, by venography between the seventh and tenth postoperative day. PDVT was present in 10 patients in the ENX group and in four patients in the UFH group (8.2 and 3.6% respectively, NS). The incidence of PDVT was 8% after aortic or aortoiliac aneurysmectomy, 7% after aortofemoral revascularisation, and 3.4% after femoropopliteal or femorodistal bypass. The overall incidence of PDVT after aortic surgery was 7.5% (95% CI 5.4-9.7). There was no pulmonary embolism. Intra-operative blood loss and postoperative bleeding events did not differ significantly between the ENX and UFH groups. After 1 month follow-up, no clinical event or death could be related to PDVT or pulmonary embolism. In conclusion, in vascular surgery ENX is as safe and effective in the prevention of PDVT as is UFH.     

The transfer of metallic contamination via contact between solid objects

The transfer of metallic contamination via solid contact is an almost non documented topic in the literature when compared to the spread through liquids which is has been intensively investigated for cleaning studies.This paper presents the transfer mechanisms of metallic aggregates from substrate to substrate though contact with tools used during wafer processing. In addition we propose models which agree with the experimental observations. The influence of several parameters on the transfer coefficients has been investigated, including the type of contamination (deposited films, particles…), the size or shape of the particle, the composition of the particle (metallic or dielectric), the substrate and the roughness and flatness of the plates used to hold the wafers during processing as well as the substrate surface composition (bare Si, oxidized…).The transfer of metals via the contact between solid objects only occurs from particular mechanisms. Not considering electrical forces, the first order parameter on the transfer is the particle size. Global transfer by contact occurs mainly in the 0.5-5 μm range and can be as high as 10%. For the second order, the parameters mentioned previously can affect the transfer of the particles, for example, an increase of the particle roughness induces an increase of the separation distance between particle and substrate which consequently decreases the Van der Waals interactions.     

Hydraulic anisotropy of homogeneous soils and rocks: influence of the densification process

Many values of the ratio k_max/k_min are available for clays and rocks which can be cut for tests in different directions. In comparison, few reliable results are available for non-cohesive materials. The hydraulic anisotropy ratios of homogeneous clays, rocks and granular soils appear to be very similar. In particular, k_max/k_min seems to be lower than 4, which confirms that this ratio has an upper limit related to the shape of particles, their arrangement, or the directional tortuosity within the pore space. In the bedding plane of sedimentary rocks, the ratio k_b.max/k_b.min is usually lower than 1.5, thus these rocks are nearly isotropic in their bedding plane. In granular soils, the k_h/k_v, contrary to common opinion, is not always higher than 1. Experimental values for sands and gravels are in the 0.75 to 4.1 range. The influence of densification on hydraulic anisotropy is found to be similar for a sand and a clay, and probably for any soil having settled in still water and influenced subsequently only by gravity. The hydraulic anisotropy of sandstone is found to be in continuity with that of sand, and it increases with densification.     

Antineoplastic agents. 397: Isolation and structure of sesterstatins 4 and 5 from Hyrtios erecta (the Republic of Maldives)

The wide ranging marine sponge Hyrtios erecta is the source of the spongistatins, a new class of macrocyclic lactone antineoplastic agents. Continuation of a detailed investigation of cancer cell growth inhibitory (P388 lymphocytic leukemia) fractions (trace) from H. erecta has revealed the presence (10(-5) to 10(-7)% yield) of cytotoxic pentacyclic sesterterpenes. Employing P388 leukemia and human tumor cell line-guided bioassay techniques, two new moderate inhibitors of cancer cells were isolated and named sesterstatins 4 (1a, P388 ED50 4.9 micrograms/mL) and 5 (1b, DU-145 prostate GI50 1.9 micrograms/mL). Similar to other sesterterpenes, sesterstatin 5 inhibited growth of a Gram-positive bacterium. High field (500 MHz) 2-D NMR techniques were primarily employed for initial structural assignments, and structural assignments were confirmed by X-ray crystal structure determination of sesterstatin 4 (1a) and 5 (1b).     

A study of spatial parameters encoded during exploration in hamsters.

In two experiments the exploratory reactions of hamsters to various rearrangements of familiar objects were examined. During two sessions, the subjects were allowed to explore a circular, open field containing four different objects. During a third test session, one or several objects were displaced, changing the shape and/or the size of the area defined by the object set. Significant reexploration was found when the change brought about during the test session affected the geometrical relations between the objects or when an object was removed. In contrast, changes that did not modify the geometrical configuration of the arrangement of the objects, but only modified the distance of one object to another, did not elicit any reexploration. Additionally, it was found that selective reexploration of the actually displaced objects occurred only when the change removed this object a certain distance from the others. These results are discussed in terms of stimulus complexity and more generally with regard to the spatial parameters that are selected, processed, and stored during exploration. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Further clinical evaluations elicited by functional biological investigations in childhood autism

Data on the protective role of antioxidants in models of atherosclerosis are only partially confirmed in man. Observational and epidemiological data, as well as randomized trials, provide no clear cut indications, because of positive and disappointing results on the use of antioxidants in cardiovascular protection. Despite the lack of a general consensus, recent data reinforce the concept that the regular intake of antioxidants present in food limits the progression of atherosclerosis. When it is possible to monitor the efficacy of any antioxidant therapy with validated markers of oxidation, the potential influence of vitamins and antioxidants on coronary artery disease may eventually be resolved.     

Investigation on the properties of linear PLA-poloxamer and star PLA-poloxamine copolymers for temporary biomedical applications

The objective of this work was to develop and study new biodegradable thermoplastics with improved mechanical properties for potential use as temporary implantable biomaterials. Linear poloxamer and star-shaped poloxamine have been used as macroinitiators for the ring-opening polymerization (ROP) of lactide to yield high molecular weight PLA-based thermoplastic block copolymers. The influence of the nature of the macroinitiator, PLA crystallinity and initial molecular weight on the copolymers properties was investigated by performing a 7-week degradation test in PBS. The evaluation of water uptakes and molecular weights during the degradation pointed out an early hydrolytic degradation of the 100-kg?mol^? 1 copolymers compared to the 200-kg?mol^? 1 ones (molecular weight decrease of ca. 40% and 20%, respectively). A dramatic loss of tensile mechanical properties was also observed for the 100-kg?mol^? 1 copolymers, whereas the 200-kg?mol^? 1 copolymers showed stable or even slightly improved properties with Young's moduli around 500 MPa and yield strains around 3% to 4%. Finally, the cytocompatibility of the more stable 200 kg?mol^? 1 copolymers was confirmed by murine mesenchymal stem cells (MSCs) culture.     

Local Tomography Study of the Fracture of an ERG Metal Foam

As one of the most important analysis techniques for non‐destructive imaging, X‐ray tomography has been widely used in materials science, medical science, and industry to evaluate the behavior of porous materials. By using this method, a three dimensional volume can be inspected in order to visualize in situ the progress of damage in materials and this can be analyzed qualitatively and quantitatively. In the present study, we have used X‐ray tomography to investigate the fracture behavior of an ERG open cell aluminum foam. The process of damage development of a sample undergoing tension and the relation between the inter‐metallics and the cracks can be observed totally by the X‐ray tomography set‐up. Local tomography has in particular been used to image the microstructure at high resolution. A finite element model has also been developed in order to simulate this process of the damage using the 3D data obtained by the tomography.     

Analytical electron tomography mapping of the SiC pore oxidation at the nanoscale

Silicon carbide is a ceramic material that has been widely studied because of its potential applications, ranging from electronics to heterogeneous catalysis. Recently, a new type of SiC materials with a medium specific surface area and thermal conductivity, called β-SiC, has attracted overgrowing interest as a new class of catalyst support in several catalytic reactions. A primary electron tomography study, performed in usual mode, has revealed a dual surface structure defined by two types of porosities made of networks of connected channels with sizes larger than 50 nm and ink-bottled pores with sizes spanning from 4 to 50 nm. Depending on the solvent nature, metal nanoparticles could be selectively deposited inside one of the two porosities, a fact that illustrates a selective wetting titration of the two types of surfaces by different liquids. The explaining hypothesis that has been put forward was that this selectivity against solvents is related to the pore surface oxidation degree of the two types of pores. A new technique of analytical electron tomography, where the series of projections used to reconstruct the volume of an object is recorded in energy filtered mode (EFTEM), has been implemented to map the pore oxidation state and to correlate it with the morphology and the accessibility of the porous network. Applied, for the first time, at a nanoscale resolution, this technique allowed us to obtain 3D elemental maps of different elements present in the analysed porous grains, in particular oxygen; we found thus that the interconnected channel pores are more rapidly oxidized than the ink-bottled ones. Alternatively, our study highlights the great interest of this method that opens the way for obtaining precise information on the chemical composition of a 3D surface at a nanometer scale.