Development of early expressive and communicative action: Reinterpreting the evidence from a dynamic systems perspective.

A systems approach is introduced and applied to the development of expressive and communicative action of infants in the first year of life. In this approach, expressive and communicative actions are organized, as part of cooperative systems with other elements of the infants' physiology, cognition, behavior, and social environment. A systems approach presumes that order arises dynamically as a result of the interaction between the cooperating elements that are changing asynchronously, rather than as the result of centrally coordinated developmental change that is synchronous across domains. The systems approach further assumes that the control parameter responsible for eliciting developmental change may be different depending on age, context, and task. It offers a means to understand previously unexplained developmental phenomena: the appearance of mature forms of expression before mature functon has been achieved, the asynchronous rates of development of communicative-action components, discontinuous developmental shifts arising from continuous processes, and the process by which adults influence communicative development. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Dantrolene inhibition of sarcoplasmic reticulum Ca2+ release by direct and specific action at skeletal muscle ryanodine receptors

The skeletal muscle relaxant dantrolene inhibits the release of Ca2+ from the sarcoplasmic reticulum during excitation-contraction coupling and suppresses the uncontrolled Ca2+ release that underlies the skeletal muscle pharmacogenetic disorder malignant hyperthermia; however, the molecular mechanism by which dantrolene selectively affects skeletal muscle Ca2+ regulation remains to be defined. Here we provide evidence of a high-affinity, monophasic inhibition by dantrolene of ryanodine receptor Ca2+ channel function in isolated sarcoplasmic reticulum vesicles prepared from malignant hyperthermia-susceptible and normal pig skeletal muscle. In media simulating resting myoplasm, dantrolene increased the half-time for 45Ca2+ release from both malignant hyperthermia and normal vesicles approximately 3.5-fold and inhibited sarcoplasmic reticulum vesicle [3H]ryanodine binding (Ki approximately 150 nM for both malignant hyperthermia and normal). Inhibition of vesicle [3H]ryanodine binding by dantrolene was associated with a decrease in the extent of activation by both calmodulin and Ca2+. Dantrolene also inhibited [3H]ryanodine binding to purified skeletal muscle ryanodine receptor protein reconstituted into liposomes. In contrast, cardiac sarcoplasmic reticulum vesicle 45Ca2+ release and [3H]ryanodine binding were unaffected by dantrolene. Together, these results demonstrate selective effects of dantrolene on skeletal muscle ryanodine receptors that are consistent with the actions of dantrolene in vivo and suggest a mechanism of action in which dantrolene may act directly at the skeletal muscle ryanodine receptor complex to limit its activation by calmodulin and Ca2+. The potential implications of these results for understanding how dantrolene and malignant hyperthermia mutations may affect the voltage-dependent activation of Ca2+ release in intact skeletal muscle are discussed.     

DIDS: rapidly prototyping configuration design systems

The domain independent design system (DIDS) provides a set of tools for rapidly constructing new configuration design systems from a library of reusable software elements called mechanisms. A DIDS user begins by creating a model of the problem domain and the task to be automated. This includes describing a library of parts from which new artifacts could be configured, optimization and preference criteria, and functionality constraints. DIDS analyzes this input and automatically builds an operational prototype system by selecting and combining mechanisms. DIDS' ability to automate this process is derived from its model of configuration design, which enables reusable mechanisms to be identified and automatically selected based on a problem's characteristics. The use of DIDS is illustrated by showing how DIDS solved an elevator-configuration problem.     

The effect of grain-size on the stress and velocity fields ahead of a crack in a material which deforms by Coble creep

The stress and velocity fields ahead of a grain-boundary crack in a material which deforms by Coble creep are investigated for a series of grain sizes using the numerical analysis technique established by Cocks [1–3]. The numerical results are compared with the linear viscous fields obtained by the boundary element method and the finite element method. It is demonstrated that a detailed knowledge of the micromechanical processes of material transport and deformation are required to determine the stress and displacement fields for the grains which immediately surround the crack tip. But the response of the surrounding material can be adequately described from a conventional linear viscous analysis of the problem.     

Numerical detection and continuation of saddle-node homoclinic bifurcations of codimension one and two

An extension of an existing truncated boundary-value method for the numerical continuation of connecting orbits is proposed to deal with homoclinic orbits to a saddle-node equilibrium. In contrast to previous numerical work by Schecter and Friedman and Doedel, the method is based on (linear) projection boundary conditions. These boundary conditions, with extra defining conditions for a saddle-node, allow the continuation of codimension-one curves of saddle-node homoclinic orbits. A new test function is motivated for detecting codimension-two points at which loci of saddle-nodes and homoclinic orbits become detached. Two methods for continuing such codim 2 points in three parameters are discussed. The numerical methods are applied to two example systems, modelling a DC Josephson junction and CO oxidation. For the former model, existing numerical results are recovered and extended; for the latter, new dynamical features are uncovered. All computations are performed using AUTO.     

Reduction of Radiation-Induced Hair Loss by Topical Application of Radioprotectors

ABSTRACT

Our transdermal permeation studies of radioprotectors in permeation-enhancing vehicles led us to hypothesize that radiation-induced hair loss could be reduced by topical application of radioprotectors. In the present study we used a hair regrowth assay in “plucked” mice to measure the radioprotective effectiveness of WR-1065, cysteine and TEMPOL when they were dissolved in a variety of vehicles, i.e., saline, dimethyl formamide (DMF), propylene glycol (PG), dimethyl sulfoxide (DMSO), ethanol. Protector effectiveness varied with radiation dose and vehicles. At 600 R, WR-1065 or cysteine, in any vehicle, reduced radiation-induced baldness scores; at 800 R, only WR-1065 in DMF and cysteine in saline, produced some protection. TEMPOL in ethanol produced protection at both the 600 and 800 R. Results suggest that suitably chosen topical application of protector/vehicle combinations can reduce radiation-induced hair loss.     

Blind MPEG-2 video watermarking robust against geometric attacks: a set of approaches in DCT domain.

A set of robust MPEG-2 video watermarking techniques is proposed, focusing on commonly used typical geometric processing for bit-rate reduction, cropping, removal of any rows, arbitrary-ratio downscaling, and frame dropping. Both the embedding and the extraction of watermarks are done in the compressed domain, so the computational cost is low. Moreover, the watermark extraction is blind, i.e., no original unwatermarked MPEG-2 video is needed for watermark extraction. The presented technique is applicable not only to MPEG-2 video, but also to other DCT-based coding videos. Selected experimental results validate our techniques.