Derivatives of hydroxyalkylthiophenols and amines as anticorrosion additives for lubricating oils

Translated from Khimiya i Tekhnologiya Topliv i Masel, No. 5, pp. 16–18, May, 1994.     

Changes in vessel ultrastructure during ischemia and reperfusion of rabbit hindlimb: implications for therapeutic intervention

Peripheral ischemia was induced in the rabbit by occlusion of the left iliac artery for 6 hr, followed by 24 hr of reperfusion. Biochemical and morphological investigations were performed to evaluate the extent of vascular and tissue injury. Blood samples for plasma enzyme determinations (creatine kinase (CK) and lactate dehydrogenase (LDH) activities) were obtained at times t = 0, t = 6, t = 30 hr. Plasma CK and LDH activities in ischemic animals were approximately twice as high as those in sham-operated animals at the end of reperfusion, although no difference was observed at the end of the period of ischemia. Morphological and morphometric analysis of extensor digitorum longus muscle from ischemic animals showed a reduction in the number of patent capillary vessels per muscle fiber (1.54 +/- 0.1 and 1.04 +/- 0.09, P < 0.05, in sham and ischemic groups, respectively; mean +/- SEM). In addition, the number of microvilli on endothelial surfaces were considerably increased in the ischemic group (0.14 +/- 0.02 and 0.41 +/- 0.01 microns -2, P < 0.001, in sham and ischemic groups, respectively). A great number of adhered leucocytes were found on the vessel surface with some leucocytes having migrated through the vessel wall. Microcirculatory damage was accompanied by the formation of microthrombi which sometimes occluded the entire vessel lumen. The infusion of 1 mg/kg/hr of cloricromene for 6 hr prevented ischemic injury in microvessels and also prevented swelling of muscle mitochondria. In the treated group the number of patent capillaries per muscle fiber was very similar to that found in sham-operated animals (1.49 +/- 0.08; P < 0.01 vs. ischemic control). In conclusion, several different cell types are involved in the pathophysiological changes which occur in microvessels during ischemia/reperfusion injury. Pharmacological interventions, which inhibit the interactions of blood cells with endothelium, may be of value in the treatment of peripheral ischemia/reperfusion injury.     

Phase Diagrams of the Systems CuBiS<Subscript>2</Subscript>-LnBiS<Subscript>3</Subscript> (Ln = La,Nd)

Phase relations in the CuBiS₂-LaBiS₃ and CuBiS₂-NdBiS₃ systems were studied for the first time using physicochemical analysis, and the T-x phase diagrams of these systems were constructed. Both systems contain quaternary compounds with the Cu₂LnBi₃S₇ stoichiometry, which melt incongruently at 815 and 910 K, respectively. Cu₂LaBi₃S₇ and Cu₂NdBi₃S₇ are isostructural with one another and crystallize in orthorhombic symmetry. The lattice parameters of Cu₂LaBi₃S₇ are a = 14.66 Å, b = 21.60 Å, and c = 4.12 Å, and those of Cu₂NdBi₃S₇ are a = 14.60 Å, b = 21.56 Å, and c = 4.10 Å.