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排序方式: 共有878条查询结果,搜索用时 12 毫秒
11.
Experimental results of self-imaging in optical fibers are reported along with an analytical model that explains the observations. Some implications for sensor design are discussed. 相似文献
12.
Identifying and integrating patient and caregiver perspectives for clinical practice guidelines on the screening and management of infectious microorganisms in hemodialysis units 下载免费PDF全文
Hilary M. Miller Allison Tong David J. Tunnicliffe Denise Campbell Jule Pinter Robert J. Commons Eugene Athan Jonathan C. Craig Nicole Gilroy Julianne Green Belinda Henderson Martin Howell Rhonda L. Stuart Carolyn van Eps Muh Geot Wong Janak de Zoysa Meg J. Jardine 《Hemodialysis international. International Symposium on Home Hemodialysis》2017,21(2):213-223
13.
Meta-analysis of linkage data under worst-case conditions: a demonstration using the human OB region
To date, few methods have been developed explicitly for meta-analysis of linkage analyses. Moreover, the methods that have been developed or suggested generally depend on certain ideal situations and have not been widely applied. In this article, we apply standard statistical theory and meta-analytic techniques in novel ways to five published papers discussing the evidence of linkage of body mass index (BMI) to the region of the human genome containing the OB gene. These methods are "inference based," meaning that they allow one to make statements about the statistical significance of the entire body of evidence. As currently developed, they do not allow specific statements to be made about the amount of variance explained by any putative locus or allow precise confidence intervals to be placed around the putative location of a linked locus. By applying these techniques to the literature on linkage in the human OB gene region, we are able to show that the evidence for linkage somewhere in the region is extremely strong (P = 1.5 x 10[-5]). 相似文献
14.
The carry-over effects value is one of the various measures one can consider to assess the quality of a round robin tournament
schedule. We introduce and discuss a new, weighted variant of the minimum carry-over effects value problem. The problem is
formulated by integer programming and an algorithm based on the hybridization of the Iterated Local Search metaheuristic with
a multistart strategy is proposed. Numerical results are presented. 相似文献
15.
This study investigated the extent and nature of university students’ use of digital technologies for learning and socialising. The findings show that students use a limited range of mainly established technologies. Use of collaborative knowledge creation tools, virtual worlds, and social networking sites was low. ‘Digital natives’ and students of a technical discipline (Engineering) used more technology tools when compared to ‘digital immigrants’ and students of a non-technical discipline (Social Work). This relationship may be mediated by the finding that Engineering courses required more intensive and extensive access to technology than Social Work courses. However, the use of technology between these groups is only quantitatively rather than qualitatively different. The study did not find evidence to support popular claims that young people adopt radically different learning styles. Their attitudes to learning appear to be influenced by lecturers’ teaching approaches. Students appear to conform to traditional pedagogies, albeit with minor uses of tools delivering content. The outcomes suggest that although the calls for transformations in education may be legitimate it would be misleading to ground the arguments for such change in students’ shifting patterns of learning and technology use. 相似文献
16.
This paper will discuss the various issues surrounding personal technologies for children. Three critical questions will
be discussed: Why can technology be important for children? What activities can technology support? And what changes should
be considered for the future? 相似文献
17.
Clara Mata Ellen K. Longmire David H. McKenna Katie K. Glass Allison Hubel 《Microfluidics and nanofluidics》2008,5(4):529-540
A recently proposed application of microfluidics is the post-thaw processing of biological cells. Numerical simulations suggest
that diffusion-based extraction of the cryoprotective agent dimethyl sulfoxide (DMSO) from blood cells is viable and more
efficient than centrifugation, the conventional method of DMSO removal. In order to validate the theoretical model used in
these simulations, a prototype was built and the flow of two parallel streams, a suspension of Jurkat cells containing DMSO
and a wash stream that contained neither cells nor DMSO, was characterized experimentally. DMSO transport in a rectangular
channel (depth 500 μm, width 25 mm and overall length 125 mm) was studied as a function of three dimensionless parameters:
depth ratio of the streams, cell volume fraction in the cell solution, and the Peclet number (Pe) based on channel depth, average flow rate and the diffusion coefficient for DMSO in water. In our studies, values of Pe ranged from O(103) to O(104). Laminar flow was ensured by keeping the Reynolds number between O(1) and O(10). Experimental results based on visual and
quantitative data demonstrate conclusively that a microfluidic device can effectively remove DMSO from liquid and cell laden
streams without compromising cell recovery. Also, flow conditions in the microfluidic device appear to have no adverse effect
on cell viability at the outlet. Further, the results demonstrate that we can predict the amount of DMSO removed from a given
device with the theoretical model mentioned previously. 相似文献
18.
Sullivan CJ Venkataraman S Retterer ST Allison DP Doktycz MJ 《Ultramicroscopy》2007,107(10-11):934-942
Atomic force microscopy (AFM) provides a unique opportunity to study live individual bacteria at the nanometer scale. In addition to providing accurate morphological information, AFM can be exploited to investigate membrane protein localization and molecular interactions on the surface of living cells. A prerequisite for these studies is the development of robust procedures for sample preparation. While such procedures are established for intact bacteria, they are only beginning to emerge for bacterial spheroplasts. Spheroplasts are useful research models for studying mechanosensitive ion channels, membrane transport, lipopolysaccharide translocation, solute uptake, and the effects of antimicrobial agents on membranes. Furthermore, given the similarities between spheroplasts and cell wall-deficient (CWD) forms of pathogenic bacteria, spheroplast research could be relevant in biomedical research. In this paper, a new technique for immobilizing spheroplasts on mica pretreated with aminopropyltriethoxysilane (APTES) and glutaraldehyde is described. Using this mounting technique, the indentation and cell elasticity of glutaraldehyde-fixed and untreated spheroplasts of E. coli in liquid were measured. These values are compared to those of intact E. coli. Untreated spheroplasts were found to be much softer than the intact cells and the silicon nitride cantilevers used in this study. 相似文献
19.
A mathematical model was developed to estimate the efficacy of coagulation–flocculation treatment for removing neutral hydrophobic organic chemicals from raw drinking water. The model assumed that the only significant removal mechanism was the destabilization and settling of organic matter containing sorbed anthropogenic organic compounds. The model was validated with standard jar tests using compounds with a range of hydrophobicities (log?Kow = 1.89?to?5.48), including contaminant candidate list chemicals, pesticides, pharmaceuticals, and endocrine disrupting chemicals. Final concentrations of test compounds after coagulation and flocculation were in good agreement with model estimations for synthetic waters composed of Aldrich (Milwaukee, WI) humic acid solutions. The final compound concentrations in coagulated natural waters from two drinking water reservoirs were about 80% lower than those estimated with the model. Overestimations of treated water concentrations by the model were attributed to an increase in sorption by natural organic matter when coiled in aluminum hydroxide flocs, compared to sorption to dispersed natural organic matter in untreated water. 相似文献
20.
Love John M.; Kisker Ellen Eliason; Ross Christine; Raikes Helen; Constantine Jill; Boller Kimberly; Brooks-Gunn Jeanne; Chazan-Cohen Rachel; Tarullo Louisa Banks; Brady-Smith Christy; Fuligni Allison Sidle; Schochet Peter Z.; Paulsell Diane; Vogel Cheri 《Canadian Metallurgical Quarterly》2005,41(6):885
Early Head Start, a federal program begun in 1995 for low-income pregnant women and families with infants and toddlers, was evaluated through a randomized trial of 3,001 families in 17 programs. Interviews with primary caregivers, child assessments, and observations of parent-child interactions were completed when children were 3 years old. Caregivers were diverse in race-ethnicity, language, and other characteristics. Regression-adjusted impact analyses showed that 3-year-old program children performed better than did control children in cognitive and language development, displayed higher emotional engagement of the parent and sustained attention with play objects, and were lower in aggressive behavior. Compared with controls, Early Head Start parents were more emotionally supportive, provided more language and learning stimulation, read to their children more, and spanked less. The strongest and most numerous impacts were for programs that offered a mix of home-visiting and center-based services and that fully implemented the performance standards early. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献