Can twice weekly hemodialysis expand patient access under resource constraints?

The convention of prescribing hemodialysis on a thrice weekly schedule began empirically when it seemed that this frequency was convenient and likely to treat symptoms for a majority of patients. Later, when urea was identified as the main target and marker of clearance, studies supported the prevailing notion that thrice weekly dialysis provided appropriate clearance of urea. Today, national guidelines on hemodialysis from most countries recommend patients receive at least thrice weekly therapy. However, resource constraints in low‐ and middle‐income countries (LMIC) have resulted in a substantial proportion of patients using less frequent hemodialysis in these settings. Observational studies of patients on twice weekly dialysis show that twice weekly therapy has noninferior survival rates compared with thrice weekly therapy. In fact, models of urea clearance also show that twice weekly therapy can meet urea clearance “targets” if patients have significant residual function or if they follow a protein‐restricted diet, as may be common in LMIC. Greater reliance on twice weekly therapy, at least at the start of hemodialysis, therefore has potential to reduce health care costs and increase access to renal replacement therapy in low‐resource settings; however, randomized control trials are needed to better understand long‐term outcomes of twice versus thrice weekly therapy.     

Cutting force and hole quality analysis in micro-drilling of CFRP

Micro-drilling in carbon fiber reinforced plastic (CFRP) composite material is challenging because this material machining is difficult due to anisotropic, abrasive and non-homogeneous properties and also downscaling of cutting process parameters affect the cutting forces and micro-drilled hole quality extensively. In this work, experimental results based statistical analysis is applied to investigate feed and cutting speed effect on cutting force components and hole quality. Analysis of variance based regression equation is used to predict cutting forces and hole quality and their trend are described by response surface methodology. Results show that roundness error and delamination factor have similar trends to those of radial forces and thrust force, respectively. Non-linear trends of cutting forces and hole quality errors are observed during downscaling of the micro-drill feed value. Optimization results show that cutting forces and hole quality errors are minimum at a feed value which is almost equal to the tool edge radius rather than at the lowest feed value. Therefore, the presented results clearly show the influences of size effects on cutting forces and hole quality parameters in micro-drilling of CFRP composite material.     

Partitioning large networks without breaking communities

The identification of cohesive communities is a key process in social network analysis. However, the algorithms that are effective for finding communities do not scale well to very large problems, as their time complexity is worse than linear in the number of edges in the graph. This is an important issue for those interested in applying social network analysis techniques to very large networks, such as networks of mobile phone subscribers. In this respect, the contributions of this paper are twofold. First, we demonstrate these scaling issues using a prominent community-finding algorithm as a case study. Then, we show that a two-stage process, whereby the network is first decomposed into manageable subnetworks using a multilevel graph partitioning procedure, is effective in finding communities in networks with more than 10⁶ nodes.     

Stacking graphic elements to avoid over-plotting

An ongoing challenge for information visualization is how to deal with over-plotting forced by ties or the relatively limited visual field of display devices. A popular solution is to represent local data density with area (bubble plots, treemaps), color (heatmaps), or aggregation (histograms, kernel densities, pixel displays). All of these methods have at least one of three deficiencies:1) magnitude judgments are biased because area and color have convex downward perceptual functions, 2) area, hue, and brightness have relatively restricted ranges of perceptual intensity compared to length representations, and/or 3) it is difficult to brush or link to individual cases when viewing aggregations. In this paper, we introduce a new technique for visualizing and interacting with datasets that preserves density information by stacking overlapping cases. The overlapping data can be points or lines or other geometric elements, depending on the type of plot. We show real-dataset applications of this stacking paradigm and compare them to other techniques that deal with over-plotting in high-dimensional displays.     

A Unified Variational Volume Registration Method Based on Automatically Learned Brain Structures

We introduce a new volumetric registration technique that effectively combines active surfaces with the finite element method. The method simultaneously aligns multi-label automatic structural segmentation results, which can be obtained by the application of existing segmentation software, to produce an anatomically accurate 3D registration. This registration is obtained by the minimization of a single energy functional. Just like registering raw images, obtaining a 3D registration this way still requires solving a fundamentally ill-posed problem. We explain through academic examples as well as an MRI dataset with manual anatomical labels, which are hidden from the registration method, how the quality of a registration method can be measured and the advantages our approach offers.     

Tri‐band composite cylindrical dielectric resonator antenna with hybrid mode excitation and cross‐polarization suppression

This communication investigates composite cylindrical dielectric resonator antenna (CDRA) for various wireless applications. Three important features of proposed antenna design are (i) realization of two different hybrid modes, that is, HEM_11δ and HEM_12δ mode in CDRA with the help of modified annular ring printed line (work as both magnetic dipole and electric dipole), both the hybrid modes support broadside radiation characteristics (ii) suppression of HEM_21δ mode, in order to reduce the cross‐polarization level in H‐plane of other hybrid modes (HEM_11δ and HEM_12δ mode) by an amount of 8‐10 dB (iii) creation of triple‐band attribute using the concept of composite antenna. The proposed antenna design has been fabricated and practically tested. Simulated outcomes show good agreement with measured outcomes. It works in three frequency bands, that is, 2.25‐2.79 GHz, 3.1‐4.0 GHz, and 5.05‐5.6 GHz. The designed antenna structure is appropriate for WLAN and WiMAX applications.     

Reconstruction of cellular biological structures from optical microscopy data

Developments in optical microscopy imaging have generated large high-resolution data sets that have spurred medical researchers to conduct investigations into mechanisms of disease, including cancer at cellular and subcellular levels. The work reported here demonstrates that a suitable methodology can be conceived that isolates modality-dependent effects from the larger segmentation task and that 3D reconstructions can be cognizant of shapes as evident in the available 2D planar images. In the current realization, a method based on active geodesic contours is first deployed to counter the ambiguity that exists in separating overlapping cells on the image plane. Later, another segmentation effort based on a variant of Voronoi tessellations improves the delineation of the cell boundaries using a Bayesian formulation. In the next stage, the cells are interpolated across the third dimension thereby mitigating the poor structural correlation that exists in that dimension. We deploy our methods on three separate data sets obtained from light, confocal, and phase-contrast microscopy and validate the results appropriately.     

Towards the development of a virtual environment-based training system for mechanical assembly operations

In this paper, we discuss the development of Virtual Training Studio (VTS), a virtual environment-based training system that allows training supervisors to create training instructions and allows trainees to learn assembly operations in a virtual environment. Our system is mainly focused on the cognitive side of training so that trainees can learn to recognize parts, remember assembly sequences, and correctly orient the parts during assembly operations. Our system enables users to train using the following three training modes: (1) Interactive Simulation, (2) 3D Animation, and (3) Video. Implementing these training modes required us to develop several new system features. This paper presents an overview of the VTS system and describes a few main features of the system. We also report user test results that show how people train using our system. The user test results indicate that the system is able to support a wide variety of training preferences and works well to support training for assembly operations.

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Study of variational inequality and equality formulations for elastostatic frictional contact problems

Summary An overview ofvariational inequality andvariational equality formulations for frictionless contact and frictional contact problems is provided. The aim is to discuss the state-of-the-art in these two formulations and clearly point out their advantages and disadvantages in terms of mathematical completeness and practicality. Various terms required to describe the contact configuration are defined.Unilateral contact law and classical Coulomb’s friction law are given.Elastostatic frictional contact boundary value problem is defined. General two-dimensional frictionless and frictional contact formulations for elastostatic problems are investigated. An example problem of a two bar truss-rigid wall frictionless contact system is formulated as an optimization problem based on the variational inequality approach. The problem is solved in a closed form using the Karush-Kuhn-Tucker (KKT) optimality conditions. The example problem is also formulated as a frictional contact system. It is solved in the closed form using a new two-phase analytical procedure. The procedure avoids use of the incremental/iterative techniques and user defined parameters required in a typical implementation based on the variational equality formulation. Numerical solutions for the frictionless and frictional contact problems are compared with the results obtained by using a general-purpose finite element program ANSYS (that uses variational equality formulation). ANSYS results match reasonably well with the solutions of KKT optimality conditions for the frictionless contact problem and the two-phase procedure for the frictional contact problem. The validity of the analytical formulation for frictional contact problems (with one contacting node) is verified. Thevariational equality formulation for frictionless and frictional, contact problems is also studied in detail. The incremental/iterative Newton-Raphson scheme incorporating the penalty approach is utilized. Studies are conducted to provide insights for the numerical solution techniques. Based on the present study it is concluded that alternate formulations and computational procedures need to be developed for analysis of frictional contact problems.