Conceptualising the link between information systems and resilience: A developing country field study

Resilience—the ability of systems to cope with external shocks and trends—is a topic of increasing interest to research and practice. That growing interest is reflected within information systems (IS), but a structured review of IS literature shows a number of knowledge gaps around the conceptual and empirical application of resilience. This paper investigates what the subdiscipline of information and communication technologies for development (ICT4D) can contribute; finding that it offers the IS discipline fresh insights that can be built into a new framework of resilience, and an arena within which this new framework can appropriately be field tested. Application of the resilience framework was undertaken through interviews and a survey in an urban community in Costa Rica; benchmarking both community resilience and “e‐resilience” (understood here as the contribution of ICTs to community resilience), and developing from these a set of action priorities. The paper reflects on what can be learned generally from this conceptualisation and operationalisation of resilience. It also reflects on what ICTs contribute to resilience in developing countries and on what this ICT4D‐based research specifically contributes to the identified IS knowledge gaps. This includes identification of a future research agenda on information systems and resilience.     

Endothelial Progenitor Cells and Rheumatoid Arthritis: Response to Endothelial Dysfunction and Clinical Evidences

Rheumatoid Arthritis (RA) is a chronic autoimmune inflammatory disease characterized by the swelling of multiple joints, pain and stiffness, and accelerated atherosclerosis. Sustained immune response and chronic inflammation, which characterize RA, may induce endothelial activation, damage and dysfunction. An equilibrium between endothelial damage and repair, together with the preservation of endothelial integrity, is of crucial importance for the homeostasis of endothelium. Endothelial Progenitor Cells (EPCs) represent a heterogenous cell population, characterized by the ability to differentiate into mature endothelial cells (ECs), which contribute to vascular homeostasis, neovascularization and endothelial repair. A modification of the number and function of EPCs has been described in numerous chronic inflammatory and auto-immune conditions; however, reports that focus on the number and functions of EPCs in RA are characterized by conflicting results, and discrepancies exist among different studies. In the present review, the authors describe EPCs’ role and response to RA-related endothelial modification, with the aim of illustrating current evidence regarding the level of EPCs and their function in this disease, to summarize EPCs’ role as a biomarker in cardiovascular comorbidities related to RA, and finally, to discuss the modulation of EPCs secondary to RA therapy.     

Dietary fiber from coconut flour: A functional food

To determine the effectiveness of dietary fiber present in coconut flour as a functional food, the following studies were conducted: (a) Dietary Fiber Composition and Fermentability of Coconut Flour; (b) The Effect of Coconut Flour on Mineral Availability from Coconut Flour Supplemented Foods; (c) Glycemic Index of Coconut Flour Supplemented Foods in Normal and Diabetic Subjects; and (d) The Cholesterol Lowering Effect of Coconut Flakes in Moderately Raised Cholesterol Levels of Humans. The dietary fiber content of coconut flour was 60.0 ± 1.0 g/100 g sample, 56% insoluble and 4% soluble. Fermentation of coconut flour produced short chain fatty acids with butyrate (1.73 ± 0.07 mmol/g fiber isolate) > acetate (1.40 ± 0.12; (P < 0.05) > propionate (0.47 ± 0.01; P < 0.05). Iron and zinc availability were highest for carrot cake (Fe, 33.3 ± 0.7%; Zn, 12.6 ± 0.1%) supplemented with 20% coconut flour while multigrain loaf supplemented with 10% and macaroons with 25% coconut flour were highest for calcium availability (63.4 ± 8.0% and 38.7 ± 1.1%, respectively). Increasing concentrations of dietary fiber from coconut flour did not affect mineral availability from all test foods. The significantly low glycemic index foods (< 60 mmol × min/l) investigated were: macaroons (45.7 ± 3.0), carrot cake (51.8 ± 3.3) and brownies (60.1 ± 5.4) with 20–25% coconut flour. The test foods containing 15% coconut flour has a glycemic index ranging from 61 to 77 mmol × min/l. Among the test foods, pan de sal (87.2 ± 5.5) and multigrain loaf (85.2 ± 6.8) gave significantly higher glycemic index with 5% and 10% coconut flour. On the other hand, granola bar and cinnamon which contained 5% and 10% coconut flour, respectively gave a glycemic index ranging from 62 to 76 mmol × min/l and did not differ significantly from the test foods containing 15% coconut flour (P < 0.05). A very strong negative correlation (r = − 85, n = 11, P < 0.005) was observed between the glycemic index and dietary fiber content of the test foods supplemented with coconut. There was a significant reduction (%) in serum total and LDL cholesterol for: oat bran flakes, 8.4 ± 1.4 and 8.8 ± 6.7, respectively; 15% coconut flakes, 6.9 ± 1.1 and 11.0 ± 4.0, respectively; and 25% coconut flakes, 10.8 ± 1.3 and 9.2 ± 5.4, respectively (P < 0.05). Serum triglycerides were significantly reduced for all test foods: corn flakes, 14.5 ± 6.3%; oat bran flakes, 22.7 ± 2.9%; 15% coconut flakes, 19.3 ± 5.7%; and 25% coconut flakes, 21.8 ± 6.0% (P < 0.05). Results from the above study can be a basis in the development of coconut flour as a functional food.

Industrial relevance

The functionality of coconut flour in terms of prevention for risk of chronic diseases, e.g. diabetes mellitus, cardiovascular diseases (CVD) and colon cancer, revealed increase production of coconut and coconut flour. The production of coconut flour is very economical because it can be produced in a small or large scale. The raw material is obtained from the by-product (waste) of the coconut milk industry and the process and equipment used in its production is simple and cheap. Coconut flour as a good source of dietary fiber can be added to bakery products, recipes and other food products for good health.     

Diffusional System Based on Tolazoline Hydrochloride Included in a Reticulated Carboxymethylcellulose Hydrogel

This paper presents a diffusional system consisting of tolazoline hydrochloride included into a carboxymethylcellulose based hydrogel, showing a high swelling capacity in water. The process kinetics of the drug inclusion into hydrogel as well as of the drug releasing have been studied. The tolazoline hydrochloride release was performed by elution with a simulated biological fluid within the digestive tract, at the small intestine level (pH = 8.2) where the drug is mostly absorbed. The results make evident a zero-order kinetics over the 30–400 min range, which would place the system among those with ‘sustained’ release, with obvious advantages compared with the classical drug administration.     

Clinical Significance of Molecular Subtypes in Western Advanced Gastric Cancer: A Real-World Multicenter Experience

In recent years, the molecular subtyping of gastric cancer has led to the identification of novel clinically relevant biomarkers as well as promising therapeutic targets. In parallel, the advent of checkpoint inhibitors has expanded treatment options beyond conventional chemotherapy. Compelling evidence has shown unprecedented efficacy results for anti-PD1-based therapies in the molecular subgroups of dMMR/MSI-h, EBV+ and PD-L1 CPS+ patients, to the point that these are granted approval for gastric cancer adenocarcinoma (AGC) in several countries. Despite this, cytotoxic chemotherapy remains the only treatment choice for the considerable proportion of biomarkers-negative patients. In this context, little is known about the association between subtypes-defining biomarkers (HER2, MMR/MSI, PD-L1, and EBV) and the efficacy of standard chemotherapy in non-Asian AGC. Here, we aimed to investigate the prevalence, the clinic-pathologic features, and the impact on treatment outcome of clinical molecular subtypes in a new-diagnosed Western cohort of AGC.     

CD40lbase: a database of CD40L gene mutations causing X-linked hyper-IgM syndrome

X-linked hyper-IgM syndrome (X-HIM) is an immunodeficiency caused by mutations in the gene encoding the CD40 ligand (CD40L). A database (CD40Lbase) of CD40L mutations has now been established, and the resultant information, together with other mutations reported elsewhere in the literature, is presented here.     

The influence of doping by transition metal elements on the vacancy formation energy in Fe-Al <Emphasis Type="Italic">B</Emphasis>2 phase

Based on ab initio calculations for Fe-Al B2 phase with and without the vacancies, the authors studied the influence of alloying by Ni, Cr, and V on the energy of vacancy formation. The authors predict that the presence of these alloying elements in the vicinity of the vacancy on the Fe site increases the energy of the vacancy formation. The present article discusses the changes of the electron charge redistribution in the vicinity of the vacancy in Fe-Al alloyed with these transition metals and link the preference of their site occupation with the peculiarities of the electron density redistribution. In addition, the authors report on the results of calculations of different types of antisite defects in Fe-Al and show that the formation of the antisite on the Al site is the energetically preferable configuration for this defect. The obtained results are in agreement with the experimental data.     

IMPROVED CONVERGENCE THROUGH DYNAMIC PROGRAMMING APPROACH

New hybrid methods for solving the multiplayer perceptron optimization problem are proposed which use the computation capabilities of Bellman's dynamic programming (DP) method. To solve the neural network optimization problem, we consider the case of output neurons differently from that of hidden neurons. For the neurons of the output layer we apply the conventional DP and for the hidden neurons we apply a method based on gradient approach. Computer simulation shows that the new hybrid methods outperform the gradient-based optimization methods in converging speed and avoiding the local minimum.     

Bacterial Over-Expression and Purification of the 3′phosphoadenosine 5′phosphosulfate (PAPS) Reductase Domain of Human FAD Synthase: Functional Characterization and Homology Modeling

FAD synthase (FADS, EC 2.7.7.2) is a key enzyme in the metabolic pathway that converts riboflavin into the redox cofactor, FAD. Human FADS is organized in two domains: -the 3′phosphoadenosine 5′phosphosulfate (PAPS) reductase domain, similar to yeast Fad1p, at the C-terminus, and -the resembling molybdopterin-binding domain at the N-terminus. To understand whether the PAPS reductase domain of hFADS is sufficient to catalyze FAD synthesis, per se, and to investigate the role of the molybdopterin-binding domain, a soluble “truncated” form of hFADS lacking the N-terminal domain (Δ_1-328-hFADS) has been over-produced and purified to homogeneity as a recombinant His-tagged protein. The recombinant Δ_1-328-hFADS binds one mole of FAD product very tightly as the wild-type enzyme. Under turnover conditions, it catalyzes FAD assembly from ATP and FMN and, at a much lower rate, FAD pyrophosphorolytic hydrolysis. The Δ_1-328-hFADS enzyme shows a slight, but not significant, change of K_m values (0.24 and 6.23 μM for FMN and ATP, respectively) and of k_cat (4.2 × 10⁻² s⁻¹) compared to wild-type protein in the forward direction. These results demonstrate that the molybdopterin-binding domain is not strictly required for catalysis. Its regulatory role is discussed in light of changes in divalent cations sensitivity of the Δ_1-328-hFADS versus wild-type protein.