Cell and biomolecular mechanics in silico

Recent developments in computational cell and biomolecular mechanics have provided valuable insights into the mechanical properties of cells, subcellular components and biomolecules, while simultaneously complementing new experimental techniques used for deciphering the structure-function paradigm in living cells. These computational approaches have direct implications in understanding the state of human health and the progress of disease and can therefore aid immensely in the diagnosis and treatment of diseases. We provide an overview of the computational approaches that are currently used in understanding various aspects of cell and bimolecular mechanics. Our emphasis is on state-of-the-art techniques and the progress made in addressing key challenges in biomechanics.     

Simulation for manufacturing system design and operation: Literature review and analysis

This paper provides a comprehensive review of discrete event simulation publications published between 2002 and 2013 with a particular focus on applications in manufacturing. The literature is classified into three general classes of manufacturing system design, manufacturing system operation, and simulation language/package development. The paper further categorizes the literature into 11 subclasses based on the application area. The current review contributes to the literature in three significant ways: (1) it provides a wide coverage by reviewing 290 papers; (2) it provides a detailed analysis of different aspects of the literature to identify research trends through innovative data mining approaches as well as insights derived from the review process; and (3) it updates and extends the existing classification schemes through identification and inclusion of recently emerged application areas and exclusion of obsolete categories. The results of the literature analysis are then used to make suggestions for future research.     

A miniaturized transient hot-wire device for measuring thermal conductivity of non-conductive fluids

This paper presents the design, fabrication and characterization of a novel transient hot-wire device for measurement of thermal conductivity of non-conductive fluids. The key features of the cell are small sample amount, simple fabrication, accurate measurement and transparency, which allows the study of both thermal and optical properties of the fluids. A 20 μm-diameter platinum hot wire is symmetrically suspended along the central axis of the capsulated cell to avoid the effect from the walls. A four-point resistance measurement method was used to measure the transient resistance with high accuracy. The accuracy of the thermal conductivity measurement was validated with reference values and very good agreement was achieved.     

Application of Complex Networks Theory in Urban Traffic Network Researches

Networks and Spatial Economics - Complex network theory is a multidisciplinary research direction of complexity science which has experienced a rapid surge of interest over the last two decades....     

Supercomputing of reducing sequenced bases in de novo sequencing of the human genome

The Journal of Supercomputing - DNA sequencing is one of the important sub-disciplines of bioinformatics, which has various applications in medicine, history, demography, and archaeology. De...     

Nanotechnology for Neuroscience: Promising Approaches for Diagnostics,Therapeutics and Brain Activity Mapping

Unlocking the secrets of the brain is a task fraught with complexity and challenge – not least due to the intricacy of the circuits involved. With advancements in the scale and precision of scientific technologies, we are increasingly equipped to explore how these components interact to produce a vast range of outputs that constitute function and disease. Here, an insight is offered into key areas in which the marriage of neuroscience and nanotechnology has revolutionized the industry. The evolution of ever more sophisticated nanomaterials culminates in network‐operant functionalized agents. In turn, these materials contribute to novel diagnostic and therapeutic strategies, including drug delivery, neuroprotection, neural regeneration, neuroimaging and neurosurgery. Further, the entrance of nanotechnology into future research arenas including optogenetics, molecular/ion sensing and monitoring, and piezoelectric effects is discussed. Finally, considerations in nanoneurotoxicity, the main barrier to clinical translation, are reviewed, and direction for future perspectives is provided.     

Fast low-power full-adders based on bridge style minority function and multiplexer for nanoscale

Full-adders are essential parts of digital circuits whereby many arithmetic circuits can be implemented by applying these cells. Therefore speed and power consumption of full-adders affect the performance of digital circuits, FA cell performs a predominant arithmetic operation in them. We utilise carbon nanotube field effect transistors for implementing our proposed designs due to their unique mechanical and electrical properties such as lower delay, lower power consumption, very dense and lower current off. Extensive simulation results using HSpice are reported to demonstrate the acquired significant improvement in performance of FA circuit design in comparison with the state-of-the-art work.