Creation of arteriovenous fistulae for hemodialysis in octogenarians

Elderly patients, defined as octogenarians and nonagenarians, are an increasing population entering renal replacement therapy. Advanced age appears as an exclusive factor negatively influencing dialysis practice. Elderly patients are referred late for the initiation of hemodialysis and more likely are offered catheters rather than arteriovenous fistulae (AVF), which increase mortality and negatively affect quality of life. We present our approach to the creation of vascular access for hemodialysis in this demanding population. In 2006–2012, 39 patients aged 85.9 ± 2.05 with end‐stage renal disease, mainly resulting from ischemic nephropathy, were admitted to the Department of Nephrology to establish permanent vascular access for hemodialysis: preferably AVF. Temporary dialysis catheters were implanted in uremic emergency to bridge the time to fistula creation/maturation. AVF was attempted in 87.2% of the patients. Primary AVF function was achieved in 54% of the patients. Cumulative proportional survival of AVF at months 12 and 24 was 81.5%. Ninety‐four percent of AVF were localized on the forearm: 74% in the distal and 20% in the proximal part. Mean duration of hemodialysis therapy was 20.80 ± 19.45 months. The mean time of AVF use was 15.9 ± 20.2 months. Until present, 38% have been dialyzed using AVF for 31.0 ± 18.8 months. Five patients died with functioning fistula. Eight patients initiated hemodialysis therapy with fistula. During further observation, the use of AVF increased to 62%. Elderly patients should not be denied creation of AVF as a rule. The outcome of AVF benefits more from acknowledging individual vascular conditions rather than age of the patient.     

Online version of the theorem of Thue

A sequence S is nonrepetitive if no two adjacent blocks of S are the same. In 1906 Thue proved that there exist arbitrarily long nonrepetitive sequences over 3 symbols. We consider the online variant of this result in which a nonrepetitive sequence is constructed during a play between two players: Bob is choosing a position in a sequence and Alice is inserting a symbol on that position taken from a fixed set A. The goal of Bob is to force Alice to create a repetition, and if he succeeds, then the game stops. The goal of Alice is naturally to avoid that and thereby to construct a nonrepetitive sequence of any given length.We prove that Alice has a strategy to play arbitrarily long provided the size of the set A is at least 12. This is the online version of the theorem of Thue. The proof is based on nonrepetitive colorings of outerplanar graphs. On the other hand, one can prove that even over 4 symbols Alice has no chance to play for too long. The minimum size of the set of symbols needed for the online version of Thue?s theorem remains unknown.     

Nominal Monoids

We develop an algebraic theory for languages of data words. We prove that, under certain conditions, a language of data words is definable in first-order logic if and only if its syntactic monoid is aperiodic.     

Comparative Analysis of Antioxidative Activity of Flavonoids Using HPLC–ED and Photometric Assays

The present investigation reports on the application of a new antioxidant activity assay for the examination of flavonoids. It has been shown that the high-performance liquid chromatography with electrochemical detection (HPLC–ED) measurements allow to obtain additional information about the antioxidative properties of pure compounds by measuring their half-wave potential, the chromatographic peak height, and the product of the peak height and exponent of potential. In comparison to the classical electrochemical measurements, the HPLC–ED is characterized by a much smaller detection limit. The results were compared with the standard photometric measurement based on 1,1-diphenyl-2-picrylhydrazyl radicals. The possible antioxidant activity forecasting is also discussed.     

Evoking emotions in virtual reality: schema activation via a freeze-frame stimulus

Virtual Reality - Virtual reality can be used for educational purposes, particularly in demanding professions such as firefighting. Such virtual training may be useful for preparing trainees for...     

Piperine Targets Different Drug Resistance Mechanisms in Human Ovarian Cancer Cell Lines Leading to Increased Sensitivity to Cytotoxic Drugs

Our goal was to examine the anticancer effects of piperine against the resistant human ovarian cancer cells and to explore the molecular mechanisms responsible for its anticancer effects. Our study used drug-sensitive ovarian cancer cell line W1 and its sublines resistant to paclitaxel (PAC) and topotecan (TOP). We analyzed the cytotoxic effect of piperine and cytostatic drugs using an MTT assay. The impact of piperine on protein expression was determined by immunofluorescence and Western blot. We also examined its effect on cell proliferation and migration. We noticed a different level of piperine resistance between cell lines. Piperine increases the cytotoxic effect of PAC and TOP in drug-resistant cells. We observed an increase in PTPRK expression correlated with decreased pTYR level after piperine treatment and downregulation of P-gp and BCRP expression. We also noted a decrease in COL3A1 and TGFBI expression in investigated cell lines and increased COL3A1 expression in media from W1PR2 cells. The expression of Ki67 protein and cell proliferation rate decreased after piperine treatment. Piperine markedly inhibited W1TR cell migration. Piperine can be considered a potential anticancer agent that can increase chemotherapy effectiveness in cancer patients.     

A Comparative Study of Mechanical Properties,Thermal Conductivity,Residual Stresses,and Wear Resistance of Aluminum-Alumina Composites Obtained by Squeeze Casting and Powder Metallurgy

Squeeze casting and powder metallurgy techniques were employed to fabricate AlSi12/Al₂O₃ composites, which are lightweight structural materials with potential applications in the automotive industry. The impact of the processing route on the material properties was studied. Comparative analyses were conducted for the Vickers hardness, flexural strength, fracture toughness, thermal conductivity, thermal residual stresses, and frictional wear. Our results show that the squeeze cast composite exhibits superior properties to those obtained using powder metallurgy.

     

Modulation of iron–nickel layers composition by an external magnetic field

In this article, characterization of FeNi layers deposited on a Cu plate for variable magnetic field arrangement is shown. Layers were prepared using a simple electrodeposition process, from an aqueous solution of Fe²⁺ and Ni²⁺ sulfate salts containing boric acid, an iron activator. By application of variation of current values, times, and external magnetic field orientations, the resultant film quality was examined and the efficiency of the embedded elements was investigated. The studies show differences in the coating morphology and relative composition of ferromagnetic metals (Ni, Fe) electrodeposited on a not ferromagnetic (paramagnetic) metal (Cu). The obtained layers were investigated by Scanning Electron Microscopy and Energy Dispersive X-ray Spectroscopy.     

Impact of Ozonation Process on the Microbiological Contamination and Antioxidant Capacity of Highbush Blueberry (Vaccinum corymbosum L.) Fruit during Cold Storage

In the studies conducted, the impact of the innovative ozonation procedure on the microbial state and antioxidant potential of highbush blueberry (Vaccinum corymbosum L.) stored under cold storage conditions was assessed. Microbiological analysis was carried out to determine the total number of mesophilic aerobic bacteria and the total number of fungi during the storage experiment. In addition, changes in the flavonoid, anthocyanins, and vitamin C content and the total antioxidant capacity were monitored during the storage. The degree of fruit infection with gray mold and anthracnose was determined. It was found that daily ozonation of fruits with a dose of 15 ppm for 30 min, every 12 h, for 28 days effectively reduced the development of aerobic mesophilic bacteria and fungi. On the last day of storage, symptoms of the infection by gray mold were observed in 27.5% of the control fruit, while the absence of symptoms was observed in case of the ozonated fruit. On the other hand, ozone was ineffective in case of inhibiting the infection by anthracnose. Nevertheless, the ozonation process allowed maintaining a high antioxidant potential of the fruit and substantially reduced losses of flavonoids, anthocyanins, and vitamin C. The utilized procedure has proved to be effective, providing the possibility of extensive use of ozone as a factor allowing sustaining a high commercial and consumption value of the fruit over extended time.