全文获取类型
收费全文 | 569065篇 |
免费 | 7153篇 |
国内免费 | 2405篇 |
专业分类
电工技术 | 9734篇 |
综合类 | 3149篇 |
化学工业 | 81495篇 |
金属工艺 | 23894篇 |
机械仪表 | 18135篇 |
建筑科学 | 13616篇 |
矿业工程 | 3023篇 |
能源动力 | 13252篇 |
轻工业 | 44266篇 |
水利工程 | 6290篇 |
石油天然气 | 9311篇 |
武器工业 | 107篇 |
无线电 | 69620篇 |
一般工业技术 | 111505篇 |
冶金工业 | 92509篇 |
原子能技术 | 11752篇 |
自动化技术 | 66965篇 |
出版年
2021年 | 3797篇 |
2019年 | 3743篇 |
2018年 | 20140篇 |
2017年 | 19152篇 |
2016年 | 16362篇 |
2015年 | 5002篇 |
2014年 | 7748篇 |
2013年 | 21364篇 |
2012年 | 15214篇 |
2011年 | 25734篇 |
2010年 | 20937篇 |
2009年 | 20279篇 |
2008年 | 22418篇 |
2007年 | 23270篇 |
2006年 | 14214篇 |
2005年 | 14046篇 |
2004年 | 13726篇 |
2003年 | 13471篇 |
2002年 | 12422篇 |
2001年 | 12061篇 |
2000年 | 11563篇 |
1999年 | 11874篇 |
1998年 | 27973篇 |
1997年 | 20009篇 |
1996年 | 15606篇 |
1995年 | 12126篇 |
1994年 | 10705篇 |
1993年 | 10635篇 |
1992年 | 8177篇 |
1991年 | 7665篇 |
1990年 | 7370篇 |
1989年 | 7180篇 |
1988年 | 6738篇 |
1987年 | 5972篇 |
1986年 | 5941篇 |
1985年 | 6773篇 |
1984年 | 6273篇 |
1983年 | 5733篇 |
1982年 | 5441篇 |
1981年 | 5498篇 |
1980年 | 5380篇 |
1979年 | 5066篇 |
1978年 | 4969篇 |
1977年 | 5671篇 |
1976年 | 7199篇 |
1975年 | 4370篇 |
1974年 | 4291篇 |
1973年 | 4367篇 |
1972年 | 3579篇 |
1971年 | 3255篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
261.
262.
JM Piepmeier DL Keefe MA Weinstein D Yoshida J Zielinski TT Lin Z Chen F Naftolin 《Canadian Metallurgical Quarterly》1993,32(3):422-30; discussion 430-1
Estramustine is an estradiol-based agent that has been shown to accumulate in human glioma cells, resulting in a concentration-dependent alteration in cell size and shape within minutes and an inhibition of proliferation over 3 to 6 days. We evaluated human glioblastoma cultures with [3H]thymidine incorporation assays to determine estramustine's early effects on deoxyribonucleic acid synthesis in these tumors. Because estramustine shares a common structural motif with other antimicrotubule drugs, we synthesized four A-ring conjugates of estrone that contained a carbamate moiety but lacked nitrogen mustard. These analogs were examined by [3H]thymidine incorporation and compared with vinblastine. Greater than 70% inhibition of [3H]thymidine incorporation occurred within 1 hour of treatment with estramustine at 10(-5) mol/L, which increased to 80% inhibition at 4 hours. Ethyl carbamate JE208 was nearly as effective as estramustine in inhibiting deoxyribonucleic acid synthesis, and both were more effective than vinblastine. The inhibitory effects of estramustine and estrone analogs were reversible; vinblastine was not reversible. Although estramustine and JE208 induced similar antiproliferative and morphological changes in glioblastoma cells that persisted for at least 4 days, there was a modest recovery of morphology and thymidine incorporation with JE208 after prolonged treatment. The common findings with estramustine and JE208 suggest that these agents may have a similar mechanism of action and form the basis for the investigation of new agents that may rapidly and reversibly inhibit glioblastoma. 相似文献
263.
We report a 20 month old female patient with diploid-triploid mixoploidy (46,XX/69,XXX) syndrome with hypothyroidism and precocious puberty. The triploid cell line was only expressed in the fibroblast culture and comprised the majority (95%) of the cells. Chromosome analysis of the fetal blood sample and peripheral blood sample were normal. The patient shows typical features of full triploidy (growth and severe mental retardation, cranial and facial dysmorphism, complete syndactyly of fingers 3/4, partial syndactyly of toes 2/3) and facial but no body asymmetry. At the age of 5 months central hypothyroidism and precocious puberty were diagnosed. Thin pigmented streaks were visible on the wrists and legs of the patient at the age of 16 months. This is the first patient reported so far with 46,XX/69,XXX mixoploidy suffering from hypothyroidism and precocious puberty. 相似文献
264.
A cost comparison of balloon angioplasty and stenting versus endarterectomy for the treatment of carotid artery stenosis 总被引:1,自引:0,他引:1
WD Jordan GD Roye WS Fisher D Redden HA McDowell 《Canadian Metallurgical Quarterly》1998,27(1):16-22; discussion 22-4
PURPOSE: Percutaneous transluminal angioplasty with stenting (PTAS) of the carotid artery has been advocated as an alternative treatment for high-grade stenosis. Rationale for this approach includes less morbidity, shorter recovery, and lower cost when compared with carotid endarterectomy (CEA). METHODS: The clinical results and hospital charges of patients who underwent elective treatment for carotid stenosis were reviewed. During a concurrent 14-month period, 218 patients were admitted 229 times for 234 procedures for the treatment of 239 carotid bifurcation stenoses, 109 by PTAS and 130 by CEA. Hospital charges were reviewed for each hospitalization and were categorized according to radiology, operating room, cardiac catheterization laboratory, and all other hospital charges. RESULTS: The combined incidence of postprocedure strokes and deaths were: PTAS, eight strokes (7.7%) and one death (0.9%); CEA, two strokes (1.5%) and two deaths (1.5%). Total hospital charges per admission for the two groups were $30,140 for PTAS and $21,670 for CEA. The average postprocedure length of stay for PTAS was 2.9 days (median, 2 days) and for CEA was 3.1 days (median, 3 days). Cardiac catheterization laboratory charges for the PTAS group were $12,968, whereas the operating room charges for the CEA group were $4263. When hospitalizations that were extended by complications were excluded, the average total charges for the PTAS group (n = 84) dropped to $24,848 (mean length of stay, 1.9 days) and for the CEA group (n = 111) to $19,247 (mean length of stay, 2.6 days). CONCLUSIONS: After evaluating hospital charges, PTAS for the treatment of carotid stenosis cannot currently be justified on the basis of reduced costs alone. With future cost-containing measures, total hospital charges can be reduced in both groups. 相似文献
265.
JF Favarel-Garrigues F Sztark ME Petitjean M Thico?pé P Lassié P Dabadie 《Canadian Metallurgical Quarterly》1996,82(2):312-316
Protective immunity against infection with Mycobacterium tuberculosis is imparted by T cells rather than antibodies, but B cells can play a role as antigen-presenting cells and in granuloma formation. We re-evaluated the role of B cells in the course of tuberculous infection in mu-chain knock-out (Ig-) mice. Surprisingly, the organs of M. tuberculosis-infected Ig- mice were found to have three- to eight-fold elevated counts of viable bacilli compared with normal littermates at 3-6 weeks post-infection. Splenic interferon-gamma responses to whole antigen were unimpaired, whilst proliferation to certain mycobacterial peptides was found to be diminished. However, bacille Calmette-Guérin (BCG) vaccination significantly reduced the infection in Ig- mice. The mechanisms by which B cells can influence primary tuberculous infection need further study. 相似文献
266.
Manku T. McGregor J.M. Nathan A. Roulston D.J. Noel J.-P. Houghton D.C. 《Electron Devices, IEEE Transactions on》1993,40(11):1990-1996
Results of the drift hole mobility in strained and unstrained SiGe alloys are reported for Ge fractions varying from 0 to 30% and doping levels of 1015-1019 cm-3. The mobilities are calculated taking into account acoustic, optical, alloy, and ionized-impurity scattering. The mobilities are then compared with experimental results for a boron doping concentration of 2×1019 cm-3. Good agreement between experimental and theoretical values is obtained. The results show an increase in the mobility relative to that of silicon 相似文献
267.
Kringlebotn J.T. Morkel P.R. Reekie L. Archambault J.-L. Payne D.N. 《Photonics Technology Letters, IEEE》1993,5(10):1162-1164
We report a 7.6-mW single-frequency fiber laser operating at 1545 nm, using for the first time an Er3+:Yb3+ doped fiber and a fiber grating output coupler. The laser did not exhibit self-pulsation, which is a typical problem in short three-level fiber lasers, and had a relative intensity noise (RIN) level below -145.5 dB/Hz at frequencies above 10 MHz. The linewidth of the laser was limited by the relaxation oscillation sidebands in the optical spectrum and was typically less than 1 MHz 相似文献
268.
PURPOSE: To assess the role postoperative mydriatics play after extracapsular cataract extraction (ECCE) and posterior chamber intraocular lens (IOL) implantation in causing iris modifications and in controlling inflammation. SETTING: Outpatients Department, Ninewells Hospital, Dundee, Scotland. METHODS: The prospective study comprised 136 patients who had standardized ECCE. Half the patients used a mydriatic for 2 weeks postoperatively. Anterior chamber activity, pain, and eye redness were evaluated at 2 weeks postoperatively; pupil shape, peripheral anterior synechias, IOL position, and iris adhesions, at 6 weeks. RESULTS: Iris-lens adhesions were significantly more common in the group using a mydriatic. There was no difference between the two groups in postoperative inflammation. CONCLUSION: Mydriatics should not be used routinely after ECCE with posterior chamber IOL implantation. 相似文献
269.
Cellulose diacetate and triacetate films 6–55 µm thick with a total porosity of 0.8–2% were prepared by pouring a solution on an immobile surface and by calendering. Sorption of H2S and CO2 gases and acetone vapors on these films was investigated in static and dynamic conditions. It was shown that films 6–10 µm thick prepared by calendering should be used for purification of air from H2S and CO2 and films 15–20 µm thick prepared by pouring should be used for removal of acetone vapors.Engels Institute of Technology, Saratov State University. Translated from Khimicheskie Volokna, No. 6, pp. 44–46, November–December, 1995. 相似文献
270.