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排序方式: 共有196条查询结果,搜索用时 15 毫秒
51.
Darko Veberič 《Computer Physics Communications》2012,183(12):2622-2628
52.
Milena Todorovic Balint Jelena Jelicic Biljana Mihaljevic Jelena Kostic Bojana Stanic Bela Balint Nadja Pejanovic Bojana Lucic Natasa Tosic Irena Marjanovic Maja Stojiljkovic Teodora Karan-Djurasevic Ognjen Perisic Goran Rakocevic Milos Popovic Sava Raicevic Jelena Bila Darko Antic Bosko Andjelic Sonja Pavlovic 《International journal of molecular sciences》2016,17(5)
The existence of a potential primary central nervous system lymphoma-specific genomic signature that differs from the systemic form of diffuse large B cell lymphoma (DLBCL) has been suggested, but is still controversial. We investigated 19 patients with primary DLBCL of central nervous system (DLBCL CNS) using the TruSeq Amplicon Cancer Panel (TSACP) for 48 cancer-related genes. Next generation sequencing (NGS) analyses have revealed that over 80% of potentially protein-changing mutations were located in eight genes (CTNNB1, PIK3CA, PTEN, ATM, KRAS, PTPN11, TP53 and JAK3), pointing to the potential role of these genes in lymphomagenesis. TP53 was the only gene harboring mutations in all 19 patients. In addition, the presence of mutated TP53 and ATM genes correlated with a higher total number of mutations in other analyzed genes. Furthermore, the presence of mutated ATM correlated with poorer event-free survival (EFS) (p = 0.036). The presence of the mutated SMO gene correlated with earlier disease relapse (p = 0.023), inferior event-free survival (p = 0.011) and overall survival (OS) (p = 0.017), while mutations in the PTEN gene were associated with inferior OS (p = 0.048). Our findings suggest that the TP53 and ATM genes could be involved in the molecular pathophysiology of primary DLBCL CNS, whereas mutations in the PTEN and SMO genes could affect survival regardless of the initial treatment approach. 相似文献
53.
Improvement of ammonia removal in activated sludge process with feedforward-feedback aeration controllers. 总被引:1,自引:0,他引:1
Darko Vrecko Nadja Hvala Aljaz Stare Olga Burica Marjeta Strazar Meta Levstek Peter Cerar Sebastjan Podbevsek 《Water science and technology》2006,53(4-5):125-132
In the paper three linear aeration controllers that can be easily implemented are presented and evaluated on the activated sludge process pilot plant. Controllers differ according to the information that is used about the process, which can be oxygen in the last aerobic reactor, ammonia in the last aerobic reactor and ammonia in the influent. The aeration controllers that are addressed are: oxygen cascade PI controller, ammonia cascade PI controller and ammonia feedforward-cascade PI controller. Experiments show that, in comparison with the oxygen cascade PI controller, the ammonia cascade PI controller allows better control of effluent ammonia and airflow savings of around 23%, while the ammonia feedforward-cascade PI controller gives the best reduction of ammonia peaks and can save up to 45% of the airflow. 相似文献
54.
Application of a Genetic Algorithm for the Optimization of a Complex Reservoir System in Tunisia 总被引:2,自引:2,他引:0
Mohamed Hedi Louati Sihem Benabdallah Fethi Lebdi Darko Milutin 《Water Resources Management》2011,25(10):2387-2404
A genetic algorithm (GA) model is developed and used for optimizing the allocation of water resources within a complex multiple
reservoir system located in Tunisia. The GA model considers two objectives: the water allocation to demand centers and the
salinity level of the water supply to end users. These two objectives are combined into a single objective function using
a weighting factor approach. Five different cases (representing five different weighting factor combinations) were analyzed
by the GA model to produce the “optimum” allocation of water resources for each case. The generated solutions exhibited low
variability. The results are then compared using a range of system performance indicators to measure reliability, resilience,
and vulnerability. The evaluation of the system performance is an essential step to help system managers identify the preferred
allocation strategy and it provides a comprehensive insight into system behavior. 相似文献
55.
Reaction and nucleation mechanisms of copper electrodeposition from ammoniacal solutions on vitreous carbon 总被引:2,自引:0,他引:2
Darko Grujicic 《Electrochimica acta》2005,50(22):4426-4443
The reaction and nucleation mechanisms of the electrodeposition of copper from ammoniacal solutions were investigated by cyclic voltammetric (cv) and chronoamperometric (ca) techniques, respectively. Each experiment with both electrochemical techniques was followed by morphological studies by atomic force microscopy (AFM). With respect to pH, the studies were performed on ammoniacal solutions at pH 4, pH 6, and pH 8, each representing a characteristic predominance region in E-pH diagrams. The experimental parameters were copper concentration, scanning rate, deposition potential, and electrode conditioning. It was found that at pH 4 copper electrodeposition occurs via reduction of cupric species to cuprous, which in turn can be either reduced, or disproportionated to metallic copper. At pH 6, deposition occurs from free and complexed cupric species, while at pH 8, only cupric amine complexes are involved. Copper nucleates according to instantaneous mechanisms at pH 4, and progressive nucleation mechanisms at pH 6 and pH 8. The diffusion coefficients of the copper species involved were also determined and are reported in this study. 相似文献
56.
Darko Lovrec Mitja Kastrevc Samo Ulaga 《The International Journal of Advanced Manufacturing Technology》2009,41(11-12):1066-1075
High-power transmission capacity at low-energy losses, low noise emissions, high reliability, and ease of maintenance, as well as convenient cost-effectiveness, are required for industrial applications regarding variable electro-hydraulic supply systems. Only up-to-date principles regarding volumetrically controlled hydraulic energy using variable supply systems and appropriate control strategy have proven satisfactory for these requirements. The aim of the present work was to study the applicability of a low-priced drive concept using a speed-controlled induction motor in combination with a constant-displacement pump applied in a load-sensing control strategy. The suggested approach of the drive concept has been experimentally verified on a prototype of the drive. A hydraulic press-brake used for the machining of casting products in the automotive industry was taken into consideration. 相似文献
57.
Darko Makovec Irena Priboic Zoran Samardija Miha Drofenik 《Journal of the American Ceramic Society》2001,84(11):2702-2704
The solid solubility of the aliovalent dopants Fe3+ and Nb5+ in the BaBi4 Ti4 O15 compound, a member of the family of Aurivillius bismuth-based layer-structure perovskites, has been studied using quantitative wavelength-dispersive spectroscopic microanalysis (SEM/EPMA) in combination with X-ray powder diffractometry (XRPD). The samples with nominal (starting) compositions corresponding to the chemical formulas BaBi4 Ti4–4 X Fe4 X O15 and BaBi4 Ti4–4 X Nb4 X O15 were prepared by hot forging a mixture of BaTiO3 and Bi4 Ti3 O12 with additions of Fe2 O3 or Nb2 O5 followed by a long annealing at 1100°C. The study showed that an excess charge introduced into the structure by the substitution of Ti4+ ions with aliovalent dopants was preferentially compensated by a change in the ratio of Ba2+ to Bi3+ ions in the host structure according to the general formulas of the solid solutions Ba1–4 X Bi4+4 X Ti4–4 X Fe' 4 X O15 and Ba1+4 X Bi4–4 X Ti4–4 X Nb· 4 X O15 . 相似文献
58.
A new, simple, low-temperature method for the synthesis of superparamagnetic, photocatalytic, nanocomposite particles for applications in the decomposition of pollutants in water is presented. The method is based on the coating of clusters of superparamagnetic maghemite (γ-Fe2O3) nanoparticles with a photocatalytic anatase layer using the hydrolysis of aqueous TiOSO4. The clusters of an appropriate size between 100 and 200 nm form by the simultaneous agglomeration of the aminopropyl-triethoxy-silane-grafted maghemite nanoparticles with a size of approximately 15 nm in a suspension of diluted TiOSO4. During a sudden increase of pH with the addition of NaOH the titania is heterogeneously nucleated at the cluster surfaces. If the hydrolysis was conducted at an elevated temperature of 90 °C, the titania layer was nanocrystalline anatase. The composition of the nanocomposite particles, i.e., the thickness of the anatase layer, can be controlled simply by changing the starting TiOSO4/Fe2O3 ratio for low titania contents, and by multiple coatings to get high titania contents. The photocatalytic activity of the nanocomposites was evaluated in the photocatalytic decomposition of formic acid. The activity seems to increase with an increase in the thickness and the crystallinity of the anatase coating, whereas it decreased after the calcination of the as-synthesized nanocomposite. The coating of the maghemite nanoparticles with a thin layer of insulating silica also slightly improves the photocatalytic activity. 相似文献
59.
Anja Terzić Nina Obradović Darko Kosanović Jovica Stojanović Antonije Đorđević Ljubiša Andrić Vladimir B. Pavlović 《Ceramics International》2019,45(3):3013-3022
Steatite, as ceramic with composition predominantly resting on magnesium silicate, was produced from economic resources – talc, aluminosilicate clays, and either BaCO3 or feldspar as flux. Titanium dioxide was a doping agent. Four steatite mixtures were mechanically activated in a planetary ball mill for 30, 45 or 60?min, prior to the thermal treatment. Two-step sintering with initial phase set at 1350?°C and holding period conducted at 1250?°C was applied to initiate diffusion and prevent grain growth. Thereby, a high density ceramic material with low-porous submicron structure was acquired. The effects of TiO2 addition on densification, microstructure, and dielectric characteristics of steatites were monitored. The thermal stability of green mixtures was tested by differential thermal and thermogravimetric analyses. Changes in crystallinity and mineral phase composition were observed by the X-ray diffraction technique. Microstructural visualization with spatial arrangements of individual chemical elements on surface of the sintered ceramics was acquired by scanning electron microscopy accompanied with EDS mapping. In order to test the possibility of employment of the obtained steatites in insulation materials, electrical measurements were conducted by recording variations of the dielectric constant and loss tangent as a function of alternations in the mix-design and the mechanical activation period. 相似文献
60.
David Vuilleumier Darko Kozarac Marco Mehl Samveg Saxena William J. Pitz Robert W. Dibble Jyh-Yuan Chen S. Mani Sarathy 《Combustion and Flame》2014
This study examines intermediate temperature heat release (ITHR) in homogeneous charge compression ignition (HCCI) engines using blends of ethanol and n-heptane. Experiments were performed over the range of 0–50% n-heptane liquid volume fractions, at equivalence ratios 0.4 and 0.5, and intake pressures from 1.4 bar to 2.2 bar. ITHR was induced in the mixtures containing predominantly ethanol through the addition of small amounts of n-heptane. After a critical threshold, additional n-heptane content yielded low temperature heat release (LTHR). A method for quantifying the amount of heat released during ITHR was developed by examining the second derivative of heat release, and this method was then used to identify trends in the engine data. The combustion process inside the engine was modeled using a single-zone HCCI model, and good qualitative agreement of pre-ignition pressure rise and heat release rate was found between experimental and modeling results using a detailed n-heptane/ethanol chemical kinetic model. The simulation results were used to identify the dominant reaction pathways contributing to ITHR, as well as to verify the chemical basis behind the quantification of the amount of ITHR in the experimental analysis. The dominant reaction pathways contributing to ITHR were found to be H-atom abstraction from n-heptane by OH and the addition of fuel radicals to O2. 相似文献